Effects of Hormone Therapy on Serum Lipid Levels in Postmenopausal Korean Women
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: This study was conducted to examine the effects of hormone therapy on serum lipid levels in postmenopausal Korean women.Methods: This retrospective cohort study included 154 healthy postmenopausal Korean women. Seventy-nine women took oral estrogen (conjugated equine estrogen 0.625 mg/day or equivalent), and 75 applied estrogen transdermally using 0.1% 17ß-estradiol gel. Micronized progesterone (MP) was added to 40 women of oral group and 49 women in transdermal group. Serum levels of triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and lipoprotein (a) were measured before, 3 and 6 month after hormone therapy.Results: At baseline, mean body mass index (BMI) were lower (22.76 vs. 23.74 kg/m2) and proportion of family history of cardiovascular disease (CVD) (61 vs. 39%) were higher in oral group. In oral group, LDL-C and lipoprotein(a) levels decreased, and triglyceride and HDL-C levels increased significantly after 3 and 6 months. There was no significant change in lipoprotein levels compared to the baseline in transdermal group. There were also no differences with additional MP. Changing pattern of HDL-C during 6 months was significantly different by the route of estrogen administration. Conclusion: Oral estrogen therapy might be more beneficial than transdermal estrogen in terms of lipid in postmenopausal Korean women. The estrogen effects are not influenced by adding MP. (J Menopausal Med 2015;21:104-111)
Abstract
Objectives: This study was conducted to examine the effects of hormone therapy on serum lipid levels in postmenopausal Korean women.Methods: This retrospective cohort study included 154 healthy postmenopausal Korean women. Seventy-nine women took oral estrogen (conjugated equine estrogen 0.625 mg/day or equivalent), and 75 applied estrogen transdermally using 0.1% 17ß-estradiol gel. Micronized progesterone (MP) was added to 40 women of oral group and 49 women in transdermal group. Serum levels of triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and lipoprotein (a) were measured before, 3 and 6 month after hormone therapy.Results: At baseline, mean body mass index (BMI) were lower (22.76 vs. 23.74 kg/m2) and proportion of family history of cardiovascular disease (CVD) (61 vs. 39%) were higher in oral group. In oral group, LDL-C and lipoprotein(a) levels decreased, and triglyceride and HDL-C levels increased significantly after 3 and 6 months. There was no significant change in lipoprotein levels compared to the baseline in transdermal group. There were also no differences with additional MP. Changing pattern of HDL-C during 6 months was significantly different by the route of estrogen administration. Conclusion: Oral estrogen therapy might be more beneficial than transdermal estrogen in terms of lipid in postmenopausal Korean women. The estrogen effects are not influenced by adding MP. (J Menopausal Med 2015;21:104-111)
참고문헌 (24)
- Mosca L., "Evidence-based guidelines for cardiovascular disease prevention in women : 2007 update", J Am Coll Cardiol, 49, pp.1230~1250 (2007)
- Lloyd-Jones DM., "Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age", Circulation, 113, pp.791~798 (2006)
- Bush TL., "Evidence for primary and secondary prevention of coronary artery disease in women taking oestrogen replacement therapy", Eur Heart J, 17(Suppl D), pp.9~14 (1996)
- Lee KS., "The effect of ipriflavone on serum lipid profiles in postmenopausal women", J Korean Soc Menopause, 2, pp.27~35 (1996)
- 허주미, "폐경 여성의 영양소 및 식품 섭취 상태 평가", 대한폐경학회지, 17(1), pp.12~20 (2011), 대한폐경학회[DOI]
- 권오성, "폐경여성에서 무증상 갑상선 기능 저하증과 심혈관계 위험인자와의 관련성", 대한폐경학회지, 18(3), pp.193~198 (2012), 대한폐경학회
- Lee SR., "Serum lipid profiles and thyroid function tests in elderly women", J Korean Soc Menopause, 15, pp.186~192 (2009)
- Barrett-Connor E., "Estrogen and coronary heart disease in women", JAMA, 265, pp.1861~1867 (1991)
- Stampfer MJ., "Estrogen replacement therapy and coronary heart disease : a quantitative assessment of the epidemiologic evidence", Prev Med, 20, pp.47~63 (1991)
- induced by estrogen plus progesterone replacement therapy in postmenopausal women, "Arch Intern Med", 1993, 1462~1468
- Crook D., "Transdermal hormone replacement therapy, serum lipids and lipoproteins", Br J Clin Pract Suppl, 86, pp.17~21 (1996)
- Jensen J., "Long-term effects of percutaneous estrogens and oral progesterone on serum lipoproteins in postmenopausal women", Am J Obstet Gynecol, 156, pp.66~71 (1987)
- Meschia M., "Effects of oral and transdermal hormone replacement therapy on lipoprotein(A)and lipids : a randomized controlled trial", Menopause, 5, pp.157~162 (1998)
- Rosano GM., "Comparative cardiovascular effects of different progestins in menopause", Int J Fertil Womens Med, 46, pp.248~256 (2001)
- The Writing Group for the PEPI Trial., "Effects of estrogen or estrogen", progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen, JAMA, pp.1995, 273[DOI]
- Jacobs DR. Jr., "High density lipoprotein cholesterol as a predictor of cardiovascular disease mortality in men and women : the follow-up study of the Lipid Research Clinics Prevalence Study", Am J Epidemiol, 131, pp.32~47 (1990)
- Stampfer MJ., "Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study", N Engl J Med, 325, pp.756~762 (1991)
- 전균호, "폐경여성에서 녹내장 발생과 혈중 에스트라디올 농도와의 관계", 대한폐경학회지, 19(2), pp.106~111 (2013), 대한폐경학회
- Namkung J., "Comparison of the effects of hormone replacement therapy on bone mineral density, lipid profiles, and biochemical markers of bone metabolism", J Korean Soc Menopause, 16, pp.107~115 (2010)
- Karjalainen A., "Metabolic changes induced by peroral oestrogen and transdermal oestradiol gel therapy", Br J Obstet Gynaecol, 104(Suppl 16), pp.38~43 (1997)
- Padwick ML., "Efficacy, acceptability, and metabolic effects of transdermal estradiol in the management of postmenopausal women", Am J Obstet Gynecol, 152, pp.1085~1091 (1985)
- Hyo Jeong Kim, "Effect of Transdermal Estrogen Therapy on Bone Mineral Density in Postmenopausal Korean Women", 대한폐경학회지, 20(3), pp.111~117 (2014), 대한폐경학회
- Vora AN., "Racial differences of lipoprotein subclass distributions in postmenopausal women", Ethn Dis, 18, pp.176~180 (2008)
- Espeland MA., "Effect of postmenopausal hormone therapy on lipoprotein(a)concentration. PEPI Investigators. Postmenopausal Estrogen", Progestin Interventions, 1998, pp.97, 979~986