Cell Therapy Products in Alzheimer Disease
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We are rapidly becoming an aging society, with the ongoing increase in challenges of the elderly. The age-related cognitivedecline in accordance with aging society is of major importance in public health. Recent studies have proved the impacts of sexsteroidhormone on the brain; compliant with aging, menopause and decrease in estrogen have an effect on the occurrenceand prevention of Alzheimer’s disease. A new hypothesis states that Alzheimer’s disease is a postmenopausal dementia, andis a negative form of estrogen deficiency. In this review article, we reckoned the cause of postmenopausal Alzheimer’s disease. We further investigated new cell therapies for postmenopausal Alzheimer’s disease, which are under development in somepharmaceutical companies. One remedy is cell therapy that inhibits the amyloid beta formation, and the other is the umbilical cordblood derived mesenchymal stem cell therapy. (J Menopausal Med 2017;23:1-4)
Abstract
We are rapidly becoming an aging society, with the ongoing increase in challenges of the elderly. The age-related cognitivedecline in accordance with aging society is of major importance in public health. Recent studies have proved the impacts of sexsteroidhormone on the brain; compliant with aging, menopause and decrease in estrogen have an effect on the occurrenceand prevention of Alzheimer’s disease. A new hypothesis states that Alzheimer’s disease is a postmenopausal dementia, andis a negative form of estrogen deficiency. In this review article, we reckoned the cause of postmenopausal Alzheimer’s disease. We further investigated new cell therapies for postmenopausal Alzheimer’s disease, which are under development in somepharmaceutical companies. One remedy is cell therapy that inhibits the amyloid beta formation, and the other is the umbilical cordblood derived mesenchymal stem cell therapy. (J Menopausal Med 2017;23:1-4)
참고문헌 (13)
- 전원경, "계량정보분석 기반의 연구개발 성과분석 : 치매 치료용 천연약물 분야", 동의신경정신과학회지, 22(3), pp.101~113 (2011), 대한한방신경정신과학회
- 김인경, "폐경기 여성의 폐경 지식과 폐경 관리", 대한폐경학회지, 18(2), pp.124~131 (2012), 대한폐경학회
- Kim T, "The effects of estrogen on the cognitive function and dementia", J Korean Soc Menopause, 12, pp.103~112 (2006)
- , Sookmyung Women’s University, 2013
- Park HM, "Role of estrogen in senile dementia of alzheimer type", J Korean Soc Menopause, 3, pp.99~109 (1997)
- Kwon KJ, "The potential role of melatonin on sleep deprivationinduced cognitive impairments: implication of FMRP on cognitive function", Neuroscience, 301, pp.403~414 (2015)
- Roh SI, "Embryonic stem cell therapy for neurodegenerative brain diseases", Dement Neurocogn Disord, 4, pp.68~75 (2005)
- Hye Min Lee, "Effect of Glucagon-like Peptide-1 on the Differentiation of Adipose-derived Stem Cells into Osteoblasts and Adipocytes", 대한폐경학회지, 21(2), pp.93~103 (2015), 대한폐경학회
- Kim S, "The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer's disease mice", PLoS One, 7, pp.e45757~ (2012)
- Shin JH, "Estetrol, E4", J Korean Soc Menopause, 15, pp.1~7 (2009)
- Ferger B, "Flibanserin, a drug intended for treatment of hypoactive sexual desire disorder in pre-menopausal women, affects spontaneous motor activity and brain neurochemistry in female rats", Naunyn Schmiedebergs Arch Pharmacol, 381, pp.573~579 (2010)
- 상재홍, "Flibanserin for Treating Hypoactive Sexual Desire Disorder", 대한폐경학회지, 22(1), pp.9~13 (2016), 대한폐경학회
- Kim JH, "Alzheimer's disease and estrogen", J Korean Soc Menopause, 6, pp.3~11 (2000)