본문 바로가기
KERD
논문KCI 등재

Age of Postmenopause Women: Effect of Soy Isoflavone in Lipoprotein and Inflammation Markers

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objectives: Menopause is associated with adverse metabolic changes in plasma lipoprotein and inflammation markers. Estrogens have beneficial effects on lipid metabolism and inflammation. Isoflavones (ISO) have structurally similar to estradiol. Our objective was analize the effect of soy-ISO on serum lipid and inflammatory markers (sP-selectin and sCD40L) in postmenopausal women.Methods: A 12-week randomized, double-blind, placebo-controlled intervention with soy-ISO (50  mg, twice daily) was conducted in 35 healthy postmenopausal women (55-72 years old). The women were divided in 2 groups: 20 were allocated to soy-ISO, and 15 to a placebo group.Results: The changes of total cholesterol (TC), triglycerides, low-density lipoproteins-cholesterol (LDL-C), high-density lipoprotein-cholesterol, Apo-A1, sP-selectin and sCD40L in 2 groups before and after 12-week treatment showed no statistical significance. In subgroup analysis, soy-ISO supplementation significantly decreased the levels of TC, LDL-C and sCD40L in women under 65 years old, and with null effects on serum lipid and inflammation markers in women over 65 years old. Conclusions: Soy-ISO did not significantly favorable effects on the lipid profile and inflammatory markers in postmenopausal women. However, in women under 65 years of age, soy-ISO significantly decreased the TC, LDL-C and sCD40L, whereas, no effects on lipid profile and inflammation markers in women over 65 years old were observed.

Abstract

Objectives: Menopause is associated with adverse metabolic changes in plasma lipoprotein and inflammation markers. Estrogens have beneficial effects on lipid metabolism and inflammation. Isoflavones (ISO) have structurally similar to estradiol. Our objective was analize the effect of soy-ISO on serum lipid and inflammatory markers (sP-selectin and sCD40L) in postmenopausal women.Methods: A 12-week randomized, double-blind, placebo-controlled intervention with soy-ISO (50  mg, twice daily) was conducted in 35 healthy postmenopausal women (55-72 years old). The women were divided in 2 groups: 20 were allocated to soy-ISO, and 15 to a placebo group.Results: The changes of total cholesterol (TC), triglycerides, low-density lipoproteins-cholesterol (LDL-C), high-density lipoprotein-cholesterol, Apo-A1, sP-selectin and sCD40L in 2 groups before and after 12-week treatment showed no statistical significance. In subgroup analysis, soy-ISO supplementation significantly decreased the levels of TC, LDL-C and sCD40L in women under 65 years old, and with null effects on serum lipid and inflammation markers in women over 65 years old. Conclusions: Soy-ISO did not significantly favorable effects on the lipid profile and inflammatory markers in postmenopausal women. However, in women under 65 years of age, soy-ISO significantly decreased the TC, LDL-C and sCD40L, whereas, no effects on lipid profile and inflammation markers in women over 65 years old were observed.

참고문헌 (35)

  1. Mendelsohn ME, "Molecular and cellular basis of cardiovascular gender differences", Science, 308, pp.1583~1587 (2005)
  2. Cui J, "Estrogen synthesis and signaling pathways during aging : from periphery to brain", Trends Mol Med, 19, pp.197~209 (2013)
  3. Chahal HS, "The endocrine system and ageing", J Pathol, 211, pp.173~180 (2007)
  4. Manson JE, "Estrogen plus progestin and the risk of coronary heart disease", N Engl J Med, 349, pp.523~534 (2003)
  5. Hulley S, "Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women", JAMA, 280, pp.605~613 (1998), Heart and Estrogen[DOI]
  6. Cano A, "Isoflavones and cardiovascular disease", Maturitas, 67, pp.219~226 (2010)
  7. Bertonazzi A, "The smallest available estradiol transdermal patch : a new treatment option for the prevention of postmenopausal osteoporosis", Womens Health (Lond), 11, pp.815~824 (2015)
  8. Munro IC, "Soy isoflavones: a safety review", Nutr Rev, 61, pp.1~33 (2003)
  9. Vitale DC, "Isoflavones:estrogenic activity, biological effect and bioavailability", Eur J Drug Metab Pharmacokinet, 38, pp.15~25 (2013)
  10. An J, "Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoes trogens", J Biol Chem, 276, pp.17808~17814 (2001)
  11. Messina M., "Soy and health update: Evaluation of the clinical and epidemiologic literature", Nutrients, 8, pp.E754~ (2016)
  12. Taku K, "Soy isoflavones lower serum total and LDL cholesterol in humans : a meta-analysis of 11 randomized controlled trials", Am J Clin Nutr, 85, pp.1148~1156 (2007)
  13. Fujimoto TT, "Expression and functional characterization of the P-selectin glycoprotein ligand-1 in various cells", Int J Hematol, 64, pp.231~239 (1996)
  14. Myers DD, "P-selectin and leukocyte microparticles are associated with venous thrombogenesis", J Vasc Surg, 38, pp.1075~1089 (2003)
  15. André P, "Pro-coagulant state resulting from high levels of soluble P-selectin in blood", Proc Natl Acad Sci U S A, 97, pp.13835~13840 (2000)
  16. Mach F, "Activation of monocyte", macrophage functions related to acute atheroma complication by ligation of CD40: induction of collagenase, stromelysin, and tissue factor, 1997, pp.96, 396~399
  17. Lindmark E, "Role of platelet P-selectin and CD40 ligand in the induction of monocytic tissue factor expression", Arterioscler Thromb Vasc Biol, 20, pp.2322~2328 (2000)
  18. Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge", Clin Chem, 18, pp.499~502 (1972)
  19. Allanore Y, "Increased plasma soluble CD40 ligand concentrations in systemic sclerosis and association with pulmonary arterial hypertension and digital ulcers", Ann Rheum Dis, 64, pp.481~483 (2005)
  20. Miller VT, "Effects of estrogen or estrogen", progestin regimens on heart disease risk factors in postmenopausal women, 1995, pp.273, 199~208[DOI]
  21. Alwers R, "Changes in normal lipid profile of menopausal women with combined hormone replacement therapy. Comparative clinical trial of two hormonal combinations (conjugated estrogens", medroxyprogesterone acetate versus estradiol valerate, Maturitas, pp.1999, 32[DOI]
  22. Harman SM, "Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes", Am J Med, 124, pp.199~205 (2011)
  23. Hodis HN, "Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis", Menopause, 22, pp.391~401 (2015)
  24. Kuiper GG, "Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta", Endocrinology, 139, pp.4252~4263 (1998)
  25. Oseni T, "Selective estrogen receptor modulators and phytoestrogens", Planta Med, 74, pp.1656~1665 (2008)
  26. Li J, "Does genistein lower plasma lipids and homocysteine levels in postmenopausal women? A meta-analysis", Climacteric, 19, pp.440~447 (2016)
  27. Mangano KM, "Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women : a randomized controlled trial", Nutr Res, 33, pp.1026~1033 (2013)
  28. Simental-Mendia LE, "Effect of soy isoflavone supplementation on plasma lipoprotein(a)concentrations : A metaanalysis", J Clin Lpiidol, 12, pp.16~24 (2018)
  29. Nagasawa M, "Analysis of serum soluble CD40 ligand(sCD40L)in the patients undergoing allogeneic stem cell transplantation : platelet is a major source of serum sCD40L", Eur J Haematol, 74, pp.54~60 (2005)
  30. Gerdes N, "Platelet CD40 exacerbates atherosclerosis by transcellular activation of endothelial cells and leukocytes", Arterioscler Thromb Vasc Biol, 36, pp.482~490 (2016)
  31. Gresele P, "Inhibitors of the interaction between von Willebrand factor and platelet GPIb", IX, Handb Exp Pharmacol, pp.2012[DOI]
  32. Enomoto Y, "Thromboxane A(2)promotes soluble CD40 ligand release from human platelets", Atherosclerosis, 209, pp.415~421 (2010)
  33. Guerrero JA, "Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor", J Thromb Haemost, 3, pp.369~376 (2005)
  34. Muñoz Y, "Equol is more active than soy isoflavone itself to compete for binding to throm MM boxane A(2) receptor in human platelets", Thromb Res, 123, pp.740~744 (2009)
  35. Gonzalez N, "In vitro effect of soy isoflavone and equol on soluble CD40L release stimulated by ristocetin in platelets from postmenopause women", JBiSE, 8, pp.24~30 (2015)

관련 논문AI추천

Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial임현정, 조여원, 이한송이한국영양학회 · Nutrition Research and Practice2017 · 제11권 제3호Effect of isoflavone supplementation on menopausal symptoms: a systematic review and meta-analysis of randomized controlled trials강인혜, 김지연, 이명숙, 임채홍, Choe Jeong-Sook, Yang Hee Sun한국영양학회 · Nutrition Research and Practice2022 · 제16권 제3호Effects of Legumes Consumption on the Association of Cholesterol and Bone Mineral Density in Ovariectomized Rats김나, 김정민, 박용순한국약용작물학회 · 한국약용작물학회지2012 · 제20권 제1호Effect of Isoflavones and Genistein on Glucose Metabolism in Peri- and Post-Menopausal Women: An Overview of Meta-AnalysisAfiat Maliehe, Khatereh Shariati, Maryam Kazemi, Masumeh Ghazanfarpour, Sara Ghahremani, Sara Kharghani, Talat Khadivzadeh대한폐경학회 · 대한폐경학회지2019 · 제25권 제2호Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women한진, 고경수, 고태희, 곽이섭, 김나리, 김형규, 박병주, 백영호, 서대윤, 이병두, 이성률한국영양학회 · Nutrition Research and Practice2012 · 제6권 제3호Intake of dietary phytoestrogen and indices of antioxidant and bone metabolism of pre- and post-menopausal Korean women윤지영, 장연희, 조성희한국영양학회 · Nutrition Research and Practice2007 · 제1권 제4호

이 간행물의 다른 논문 (11건)