The Effect of Levonorgestrel-releasing Intrauterine System (Mirena®) on the Mammographic Density and Breast Ultrasonographic Findings in Korean Premenopausal Women

Abstract

Objectives: The aim of the present study was to investigate the influence of levonorgestrel-releasing intrauterine system (LNG-IUS,Mirena®) on the mammographic density, mammographic findings and breast ultrasonographic findings in Korean premenopausal women. Methods: We reviewed medical records of 639 premenopausal women, who inserted LNG-IUS in our department from 2000-2011. Among these, 46 women, who underwent regular mammography (MMG) or breast ultrasonography (USG) examination in radiology department before and after insertion of the LNG-IUS after establishment of picture archiving and communication system (PACS) system in our hospital were finally included in this analysis. We compared the findings of MMG and breast USG between pre- and post-insertion of LNG-IUS. We also checked the pathologic results of any breast biopsy performed in these study participants. The Cochran-Armitage trend test was used to investigate the changes pre- and post- insertion of LNG-IUS. Results: The mean age of participants was 42.3 ± 4.9 years and the mean interval period for MMG and US follow-up (FU) was 25.5± 10.8 months and 25.2 ± 11.5 months, respectively. The density of MMG before insertion of LNG-IUS correlated well with the FU MMG density. The findings of MMG and US also correlated well before and after insertion of LNG-IUS. There was no case of breast cancer among women who were supposed to undergo breast biopsy because of abnormal findings in MMG and US. Conclusion: The use of LNG-IUS did not cause any changes in MMG density, findings of MMG, and findings of breast USG in healthy premenopausal Korean women.