Effect of Vitamin D on the Vaginal Health of Menopausal Women: A Systematic Review
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Menopause is associated with the onset of climacteric symptoms due to low estradiol levels, which may cause insufficient maturation of the vaginal mucosa. Vitamin D may regulate the growth and differentiation of cells that are adversely affected due to low estradiol levels, thereby restoring vaginal health. The objective of this systematic review, the first on this subject, was to investigate the effect of vitamin D on the vaginal health of menopausal women. PubMed, Embase, Scopus, Web of Science, and Google Scholar databases and reference lists of hand-searched articles were searched for published studies from February 2000 to November 2018. The selection criteria were as follows: randomized or quasi-randomized trials that compared the effects of vitamin D or related compounds, alone or with calcium, on vaginal health (growth and differentiation of epithelial cells, dryness, acidity [pH]) outcomes in menopausal women. The methodological quality of these studies was examined using the Cochrane tool checklist by two independent investigators, following which the data were extracted. Of six examined studies, two showed that vitamin D administration improved the growth and differentiation of vaginal epithelial cells, improved vaginal pH, and decreased vaginal dryness in menopausal women. Although the level of evidence for the effects of vitamin D on vaginal health is low in our study, we concluded that vitamin D may improve the vaginal health of women, especially during menopause.
Abstract
Menopause is associated with the onset of climacteric symptoms due to low estradiol levels, which may cause insufficient maturation of the vaginal mucosa. Vitamin D may regulate the growth and differentiation of cells that are adversely affected due to low estradiol levels, thereby restoring vaginal health. The objective of this systematic review, the first on this subject, was to investigate the effect of vitamin D on the vaginal health of menopausal women. PubMed, Embase, Scopus, Web of Science, and Google Scholar databases and reference lists of hand-searched articles were searched for published studies from February 2000 to November 2018. The selection criteria were as follows: randomized or quasi-randomized trials that compared the effects of vitamin D or related compounds, alone or with calcium, on vaginal health (growth and differentiation of epithelial cells, dryness, acidity [pH]) outcomes in menopausal women. The methodological quality of these studies was examined using the Cochrane tool checklist by two independent investigators, following which the data were extracted. Of six examined studies, two showed that vitamin D administration improved the growth and differentiation of vaginal epithelial cells, improved vaginal pH, and decreased vaginal dryness in menopausal women. Although the level of evidence for the effects of vitamin D on vaginal health is low in our study, we concluded that vitamin D may improve the vaginal health of women, especially during menopause.
참고문헌 (42)
- Ghazanfarpour M, "Association between anthropometric indices and quality of life in menopausal women", Gynecol Endocrinol, 29, pp.917~920 (2013)
- Ghazanfarpour M, "The relationship between women's attitude towards menopause and menopausal symptoms among postmenopausal women", Gynecol Endocrinol, 31, pp.860~865 (2015)
- Huang AJ, "Vaginal symptoms in postmenopausal women : self-reported severity, natural history, and risk factors", Menopause, 17, pp.121~126 (2010)
- Weber MA, "Assessment of vaginal atrophy : a review", Int Urogynecol J, 26, pp.15~28 (2015)
- Tersigni C, "Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women", J Obstet Gynaecol, 35, pp.835~838 (2015)
- Naumova I, "Current treatment options for postmenopausal vaginal atrophy", Int J Womens Health, 10, pp.387~395 (2018)
- Yildirim B, "The effects of postmenopausal Vitamin D treatment on vaginal atrophy", Maturitas, 49, pp.334~337 (2004)
- Palma F, "Vaginal atrophy of women in postmenopause. Results from a multicentric observational study: The AGATA study", Maturitas, 83, pp.40~44 (2016)
- Ballagh SA, "Vaginal hormone therapy for urogenital and menopausal symptoms", Semin Reprod Med, 23, pp.126~140 (2005)
- Dessie SG, "Effect of vaginal estrogen on pessary use", Int Urogynecol J, 27, pp.1423~1429 (2016)
- Lynch C, "Vaginal estrogen therapy for the treatment of atrophic vaginitis", J Womens Health(Larchmt), 18, pp.1595~1606 (2009)
- Gambacciani M, "Hormone replacement therapy and the prevention of postmenopausal osteoporosis", Prz Menopauzalny, 13, pp.213~220 (2014)
- Castelo-Branco C, "Management of post-menopausal vaginal atrophy and atrophic vaginitis", Maturitas, 52(Suppl 1), pp.S46~S52 (2005)
- Parnan emamverdikhan A, "Comparing two treatment methods of vitamin E suppository and conjugated estrogen vaginal cream on the quality of life in menopausal women with vaginal atrophy", J Midwifery Reprod Health, 2, pp.253~261 (2014)
- 이아름, "Vitamin D Proliferates Vaginal Epithelium through RhoA Expression in Postmenopausal Atrophic Vagina tissue", Molecules and Cells, 40(9), pp.677~684 (2017), 한국분자세포생물학회[DOI]
- Welsh J, "Cellular and molecular effects of vitamin D on carcinogenesis", Arch Biochem Biophys, 523, pp.107~114 (2012)
- Irwýng MF, "Fitzpatrick's dermatology in general medicine" (1999), McGraw-Hill
- Kim TH, "Immunohistochemical detection of the 1, 25-dihydroxy vitamin D receptor in the human vagina", Iran J Reprod Med, 12, pp.805~810 (2014)
- Pike JW, "The vitamin D receptor : new paradigms for the regulation of gene expression by 1, 25-dihydroxyvitamin D(3)", Endocrinol Metab Clin North Am, 39, pp.255~269 (2010)
- Riazi H, "The comparison of spiritual health and self-esteem in women with and without sexual violence", Electron Physician, 9, pp.5705~5711 (2017)
- Bala R, "Authenticity of vitamin D in modified vaginal health index in geriatric subjects", Int J Reprod Contracept Obstet Gynecol, 5, pp.4119~4122 (2016)
- Kaur H, "Role of Vitamin D in urogenital health of geriatric participants", J Midlife Health, 8, pp.28~35 (2017)
- Rad P, "The effect of vitamin D on vaginal atrophy in postmenopausal women", Iran J Nurs Midwifery Res, 20, pp.211~215 (2015)
- Checa MA, "A comparison of raloxifene and calcium plus vitamin D on vaginal atrophy after discontinuation of long-standing postmenopausal hormone therapy in osteoporotic women. A randomized, maskedevaluator, one-year, prospective study", Maturitas, 52, pp.70~77 (2005)
- Zareai M, "Effect of vitamin E on the vaginal atrophy of postmenopausal women", Value Health, 17, pp.A750~ (2014)
- Saeideh Z, "Comparing the effects of continuous hormone replacement therapy and tibolone on the genital tract of menopausal women;a randomized controlled trial", J Reprod Infertil, 11, pp.183~187 (2010)
- Carranza-Lira S, "Changes in maturation index and vaginal dryness in postmenopausal women who use or not calcitriol", Rev Med Inst Mex Seguro Soc, 50, pp.537~540 (2012)[DOI]
- Mucci M, "Soy isoflavones, lactobacilli, Magnolia bark extract, vitamin D3 and calcium. Controlled clinical study in menopause", Minerva Ginecol, 58, pp.323~334 (2006)
- LeBlanc ES, "Vitamin D levels and menopause-related symptoms", Menopause, 21, pp.1197~1203 (2014)
- LeBlanc ES, "Calcium and vitamin D supplementation do not influence menopause-related symptoms : Results of the Women's Health Initiative Trial", Maturitas, 81, pp.377~383 (2015)
- Avenell A, "Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis", Cochrane Database Syst Rev., 2, pp.CD000227~ (2009)
- Kennel KA, "Vitamin D deficiency in adults: when to test and how to treat", Mayo Clin Proc, 85, pp.752~757 (2010)
- Bolland MJ, "Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis", BMJ, 341, pp.c3691~ (2010)
- Bolland MJ, "Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis", BMJ, 342, pp.d2040~ (2011)
- Bolland MJ, "Calcium and vitamin D supplements and health outcomes : a reanalysis of the Women's Health Initiative(WHI)limited-access data set", Am J Clin Nutr, 94, pp.1144~1149 (2011)
- Bischoff-Ferrari HA, "Benefit-risk assessment of vitamin D supplementation", Osteoporos Int, 21, pp.1121~1132 (2010)
- Zeyneloglu HB, "The effect of raloxifene in association with vitamin D on vaginal maturation index and urogenital symptoms in postmenopausal osteoporotic women", Fertil Steril, 88, pp.530~532 (2007)
- Avenell A, "Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men", Cochrane Database Syst Rev, 4, pp.CD000227~ (2014)
- Purdue-Smithe AC, "Vitamin D and calcium intake and risk of early menopause", Am J Clin Nutr, 105, pp.1493~1501 (2017)
- Ghazanfarpour M, "The efficacy of Iranian herbal medicines in alleviating hot flashes : a systematic review", Int J Reprod Biomed(Yazd), 14, pp.155~166 (2016)
- Chen MN, "Efficacy of phytoestrogens for menopausal symptoms : a meta-analysis and systematic review", Climacteric, 18, pp.260~269 (2015)
- Tadir Y, "Light and energy based therapeutics for genitourinary syndrome of menopause : consensus and controversies", Lasers Surg Med, 49, pp.137~159 (2017)