The Efficacy of Herbal Supplement Danggui Buxue Tang for Relieving Menopausal Symptoms
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: This study aimed to further explore the efficacy and safety of Danggui Buxue Tang (DBT), a simple herbal formula, for improving the quality of life of women suffering from menopausal symptoms.Methods: A third clinical trial to determine the clinical efficacy of high-dose DBT for a period of 12 weeks was carried out. The standard Menopause-Specific Quality of Life (MENQOL) assessment chart was used for the evaluation. Safety was defined as an absence of direct estrogenic effects, serum inflammatory cytokines. Notably, interleukin IL-6, IL-8 and tumor necrosis factor TNF-α, known to be directly related to estrogenic reactions in menopause studies, were monitored.Results: The third clinical trial indicated an overall improvement in the four domains of MENQOL, offering further proof of the efficacy of DBT demonstrated in the two previous trials. The serial checks of the three cytokines related to estrogen activities did not show either upward or downward trends. The haphazard behavior reactions of the three cytokines offered indirect indications that DBT improved the MENQOL independently from estrogen activities.Conclusions: The three clinical trials using DBT to relieve menopausal syndrome have offered solid evidence for its efficacy. The uncertainty regarding whether the “phytoestrogen” contained in DBT had bioactivities similar to estrogen was alleviated through the confirmation that no strict estrogenic bioactivities were observed. The issue of safety was further clarified via laboratory platform studies on DBT, which not only showed the lack of similarity with estrogen actions but also confirmed the value of combining the two herbs in the classic formula.
Abstract
Objectives: This study aimed to further explore the efficacy and safety of Danggui Buxue Tang (DBT), a simple herbal formula, for improving the quality of life of women suffering from menopausal symptoms.Methods: A third clinical trial to determine the clinical efficacy of high-dose DBT for a period of 12 weeks was carried out. The standard Menopause-Specific Quality of Life (MENQOL) assessment chart was used for the evaluation. Safety was defined as an absence of direct estrogenic effects, serum inflammatory cytokines. Notably, interleukin IL-6, IL-8 and tumor necrosis factor TNF-α, known to be directly related to estrogenic reactions in menopause studies, were monitored.Results: The third clinical trial indicated an overall improvement in the four domains of MENQOL, offering further proof of the efficacy of DBT demonstrated in the two previous trials. The serial checks of the three cytokines related to estrogen activities did not show either upward or downward trends. The haphazard behavior reactions of the three cytokines offered indirect indications that DBT improved the MENQOL independently from estrogen activities.Conclusions: The three clinical trials using DBT to relieve menopausal syndrome have offered solid evidence for its efficacy. The uncertainty regarding whether the “phytoestrogen” contained in DBT had bioactivities similar to estrogen was alleviated through the confirmation that no strict estrogenic bioactivities were observed. The issue of safety was further clarified via laboratory platform studies on DBT, which not only showed the lack of similarity with estrogen actions but also confirmed the value of combining the two herbs in the classic formula.
참고문헌 (28)
- Palacios S, "Age of menopause and impact of climacteric symptoms by geographical region", Climacteric, 13, pp.419~428 (2010)
- North American Menopause Society, "Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society", Menopause, 17, pp.242~255 (2010)
- Yang YH, "Prescription pattern of traditional Chinese medicine for climacteric women in Taiwan", Climacteric, 12, pp.541~547 (2009)
- Tan D, "Relief of vasomotor symptoms and vaginal atrophy with three doses of conjugated estrogens and medroxyprogesterone acetate in postmenopausal Asian women from 11 countries : The Pan-Asia menopause(PAM)study", Maturitas, 52, pp.35~51 (2005)
- Morabia A, "Recent reversal of trends in hormone therapy use in a European population", Menopause, 13, pp.111~115 (2006)
- Kaufert P, "Women and menopause: beliefs, attitudes, and behaviors. The North American Menopause Society 1997 Menopause Survey", Menopause, 5, pp.197~202 (1998)
- Hulley S, "Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen", progestin Replacement Study (HERS) Research Group, 1998, pp.280, 605~613
- Rossouw JE, "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial", JAMA, 288, pp.321~333 (2002)
- Brzezinski A, "Phytoestrogens: the "natural" selective estrogen receptor modulators?", Eur J Obstet Gynecol Reprod Biol, 85, pp.47~51 (1999)
- Chinese Pharmacopoeia Commission, "Pharmacopoeia of the People’s Republic of China" (2005), People's Medical Publishing House
- Gong AG, "The estrogenic properties of Danggui Buxue Tang, a Chinese herbal decoction, are triggered predominantly by calycosin in MCF-7 cells", J Ethnopharmacol, 189, pp.81~89 (2016)
- Zhou L, "A standardized extract of Danggui Buxue Tang decoction selectively exerts estrogenic activities distinctly from tamoxifen", Phytother Res, 35, pp.1456~1467 (2021)
- Kwan KKL, "Danggui Buxue Tang, a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix, improves mitochrondial bioenergetics in osteoblast", Phytomedicine, 88, pp.153605~ (2021)
- Kwan KKL, "Integrated omics reveals the orchestrating role of calycosin in Danggui Buxue Tang, a herbal formula containing Angelicae Sinensis Radix and Astragali Radix, in inducing osteoblastic differentiation and proliferation", Front Pharmacol, 12, pp.670947~ (2021)
- Haines CJ, "A randomized, double-blind, placebo-controlled study of the effect of a Chinese herbal medicine preparation(Dang Gui Buxue Tang)on menopausal symptoms in Hong Kong Chinese women", Climacteric, 11, pp.244~251 (2008)
- Wang CC, "A randomized, double-blind, multiple-dose escalation study of a Chinese herbal medicine preparation(Dang Gui Buxue Tang)for moderate to severe menopausal symptoms and quality of life in postmenopausal women", Menopause, 20, pp.223~231 (2013)
- Cioffi M, "Cytokine pattern in postmenopause", Maturitas, 41, pp.187~192 (2002)
- Milan-Mattos JC, "Effects of natural aging and gender on pro-inflammatory markers", Braz J Med Biol Res, 52, pp.e8392~ (2019)
- Gao Q, "Verification of the formulation and efficacy of Danggui Buxue Tang(a decoction of Radix Astragali and Radix Angelicae Sinensis) : an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae", Chin Med, 2, pp.12~ (2007)
- Xie QF, "Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats", J Ethnopharmacol, 144, pp.567~575 (2012)
- Gao QT, "Danggui buxue tang--a Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor alpha in cultured MCF-7 cells", FEBS Lett, 581, pp.233~240 (2007)
- Huang WY, "Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women", PLoS One, 12, pp.e0184011~ (2017)
- Malutan A, "Interleukin-8 and vasomotor symptoms in natural and surgically induced menopause", Acta Endo (Buc), 9, pp.133~144 (2013)
- Kinney E, "Maternal-child nurshing", pp.655~ (2012), Elsevier Science Health Science Division
- Greenblum CA, "Midlife women : symptoms associated with menopausal transition and early postmenopause and quality of life", Menopause, 20, pp.22~27 (2013)
- Lewis JE, "Further psychometric property development of the Menopause-Specific Quality of Life questionnaire and development of a modified version, MENQOLIntervention questionnaire", Maturitas, 50, pp.209~221 (2005)
- Chan PH, "Quality control of Danggui Buxue Tang, a traditional Chinese medicine decoction, by 1H-NMR metabolic profiling", Evid Based Complement Alternat Med, 2014, pp.567893~ (2014)
- Zhang WL, "Hydrolysis of glycosidic flavonoids during the preparation of Danggui Buxue Tang : an outcome of moderate boiling of Chinese herbal mixture", Evid Based Complement Alternat Med, 2014, pp.608721~ (2014)