Evening Primrose Oil for Menopause Hot Flashes: Systematic Review and Meta-Analysis
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Hormone replacement therapy (HRT) used to treat hot flashes has side effects, such as an increased risk of coronary heart disease and breast cancer. There are ongoing controversies regarding the risk of ovarian cancer associated with HRT. HRT is best avoided in conditions such as liver or gallbladder disease and gastrointestinal disorders. Evening primrose oil (EPO) has been used as an alternative treatment for hot flashes. We conducted a systematic review of randomized controlled trials and controlled clinical trials, following the PRISMA guidelines, to compare EPO with placebo or other interventions in alleviating hot flashes in menopausal women. We analyzed the data using Review Manager version 5.3, in conjunction with the Cochrane Collaboration tool. The severity of hot flashes was lower when EPO was administered for less than 6 months compared to placebo. However, there was no significant difference in the frequency and duration of hot flashes between EPO and placebo. Participants who received EPO complained of mild nausea and headache. EPO did not show any significant difference in the severity of hot flashes compared to black cohosh at 4 weeks; but the hot flashes were more severe at 8 weeks in the EPO group compared to black cohosh. The current evidence is insufficient to draw firm conclusions regarding the benefits of EPO in alleviating hot flashes. We hope that more research is conducted to provide sufficient evidence for menopausal women considering the use of EPO.
Abstract
Hormone replacement therapy (HRT) used to treat hot flashes has side effects, such as an increased risk of coronary heart disease and breast cancer. There are ongoing controversies regarding the risk of ovarian cancer associated with HRT. HRT is best avoided in conditions such as liver or gallbladder disease and gastrointestinal disorders. Evening primrose oil (EPO) has been used as an alternative treatment for hot flashes. We conducted a systematic review of randomized controlled trials and controlled clinical trials, following the PRISMA guidelines, to compare EPO with placebo or other interventions in alleviating hot flashes in menopausal women. We analyzed the data using Review Manager version 5.3, in conjunction with the Cochrane Collaboration tool. The severity of hot flashes was lower when EPO was administered for less than 6 months compared to placebo. However, there was no significant difference in the frequency and duration of hot flashes between EPO and placebo. Participants who received EPO complained of mild nausea and headache. EPO did not show any significant difference in the severity of hot flashes compared to black cohosh at 4 weeks; but the hot flashes were more severe at 8 weeks in the EPO group compared to black cohosh. The current evidence is insufficient to draw firm conclusions regarding the benefits of EPO in alleviating hot flashes. We hope that more research is conducted to provide sufficient evidence for menopausal women considering the use of EPO.
참고문헌 (33)
- Pinkerton JV, "Vasomotor symptoms in menopause : where we’ve been and where we’re going", J Womens Health (Larchmt), 15, pp.135~145 (2006)
- Greenblatt RB, "Estrogen therapy for postmenopausal females", N Engl J Med, 272, pp.305~308 (1965)
- Guthrie JR, "Health careseeking for menopausal problems", Climacteric, 6, pp.112~117 (2003)
- Reed SD, "Premenopausal vasomotor symptoms in an ethnically diverse population", Menopause, 21, pp.153~158 (2014)
- "ACOG Practice Bulletin No. 141: management of menopausal symptoms", Obstet Gynecol, 123, pp.202~216 (2014)
- Voda AM, "Climacteric hot flash", Maturitas, 3, pp.73~90 (1981)
- Sturdee DW, "Physiological aspects of menopausal hot flush", Br Med J, 2, pp.79~80 (1978)
- Hulley S, "Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen", progestin Replacement Study(HERS)Research Group, 1998, pp.280, 605~613
- Herrington DM, "Effects of estrogen replacement on the progression of coronary-artery atherosclerosis", N Engl J Med, 343, pp.522~529 (2000)
- Clarke SC, "A study of hormone replacement therapy in postmenopausal women with ischaemic heart disease : the Papworth HRT atherosclerosis study", BJOG, 109, pp.1056~1062 (2002)
- Beral V, "Menopausal hormone use and ovarian cancer risk : individual participant meta-analysis of 52 epidemiological studies", Lancet, 385, pp.1835~1842 (2015)
- Manson JE, "Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials", JAMA, 310, pp.1353~1368 (2013)
- Davis SR, "Reproductive endocrinology : menopausal hormone therapy-ovarian cancer risk revisited", Nat Rev Endocrinol, 11, pp.322~323 (2015)
- Lobo RA, "Hormone-replacement therapy : current thinking", Nat Rev Endocrinol, 13, pp.220~231 (2017)
- Manson JE, "Estrogen therapy and coronary-artery calcification", N Engl J Med, 356, pp.2591~2602 (2007)
- Maggio M, "Relationship between higher estradiol levels and 9-year mortality in older women : the Invecchiare in Chianti study", J Am Geriatr Soc, 57, pp.1810~1815 (2009)
- Schierbeck LL, "Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women : randomised trial", BMJ, 345, pp.e6409~ (2012)
- van Seumeren I, "Weight gain and hormone replacement therapy:are women’s fears justified?", Maturitas, 34(Suppl 1), pp.S3~S8 (2000)
- Judd HL, "Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen", Progestin Interventions(PEPI)Trial. The Writing Group for the PEPI Trial, 1996, pp.275, 370~375
- Çilgin H, "Predictors of initiating hormone replacement therapy in postmenopausal women : a cross-sectional study", ScientificWorld-Journal, 2019, pp.1814804~ (2019)
- Hickey M, "Hormone replacement therapy", BMJ, 344, pp.e763~ (2012)
- Bayles B, "Evening primrose oil", Am Fam Physician, 80, pp.1405~1408 (2009)
- Mahboubi M, "Evening primrose(Oenothera biennis)oil in management of female ailments", J Menopausal Med, 25, pp.74~82 (2019)
- Chenoy R, "Effect of oral gamolenic acid from evening primrose oil on menopausal flushing", BMJ, 308, pp.501~503 (1994)
- Dastenaie BM, "The effect of evening primrose plant on physical symptoms of menopause", J Babol Univ Med Sci, 19, pp.34~40 (2017)
- Farzaneh F, "The effect of oral evening primrose oil on menopausal hot flashes : a randomized clinical trial", Arch Gynecol Obstet, 288, pp.1075~1079 (2013)
- Mehrpooya M, "A comparative study on the effect of"black cohosh"and"evening primrose oil"on menopausal hot flashes", J Educ Health Promot, 7, pp.36~ (2018)
- Cagnacci A, "The controversial history of hormone replacement therapy", Medicina (Kaunas), 55, pp.602~ (2019)
- Lee D, "In vitro estrogenic and breast cancer inhibitory activities of chemical constituents isolated from Rheum undulatum L", Molecules, 23, pp.1215~ (2018)
- Tsoumani M, "Novel evidence-based combination of plant extracts with multitarget mechanisms of action for the elimination of hot flashes during menopause", Molecules, 27, pp.1221~ (2022)
- Jassim GA, "Strategies for managing hot flashes", J Fam Pract, 60, pp.333~339 (2011)
- Yousefi Z, "Impacts of herbal medicines on hot flash : a systematic review", J Med Plants, 15, pp.40~46 (2016)
- Bamford JT, "Oral evening primrose oil and borage oil for eczema", Cochrane Database Syst Rev, 2013, pp.CD004416~ (2013)