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Torsade de Pointes Induced by Long-Term Oral Amiodarone Therapy

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초록

Although amiodarone is generally regarded as safe with a low incidence of associated arrhythmias, torsade de pointes (TdP) has been observed usually in the presence of predisposing factors. We report a case of amiodarone-induced TdP after long-term administration of a low dose of oral amiodarone in the absence of predisposing factors.

Abstract

Although amiodarone is generally regarded as safe with a low incidence of associated arrhythmias, torsade de pointes (TdP) has been observed usually in the presence of predisposing factors. We report a case of amiodarone-induced TdP after long-term administration of a low dose of oral amiodarone in the absence of predisposing factors.

참고문헌 (8)

  1. van Opstal JM, "Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT lengthening in an animal model of acquired long QT syndrome", Circulation, 104, pp.2722~2727 (2001)
  2. Roden M, "Drug-induced prolongation of the QT interval", N Engl J Med, 350, pp.1013~1022 (2004)
  3. Khan IA, "Clinical and therapeutic aspects of congenital and acquired long QT syndrome", Am J Med, 112, pp.58~66 (2002)
  4. Podrid PJ, "Amiodarone: reevaluation of an old drug", Ann Intern Med, 122, pp.689~700 (1995)
  5. Roden DM, "A practical approach to torsade de Pointes", Clin Cardiol, 20, pp.285~290 (1997)
  6. Hohnloser SH, "Amiodarone-associated proarrhythmic effects : a review with special reference to torsae de pointes tachycardia", Ann Intern Med, 121, pp.529~535 (1994)
  7. Zeltser D, "Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors", Medicine (Baltimore), 82, pp.282~290 (2003)
  8. Priori SG, "Low penetrance in the long-QT syndrome: clinical impact", Circulation, 99, pp.529~533 (1999)

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