두개 내를 침범한 형질세포골수종 1예
A Case of Intracranial Involvement in Plasma Cell Myeloma
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Plasma cell myelomas generally manifest as bone or soft-tissue tumors with variable mass effects, pain, and infiltrative behavior. Extramedullary involvement occurs most commonly in the spleen, liver, lymph nodes, and kidneys, but intracranial involvement in plasma cell myeloma is a rare extramedullary manifestation. These authors recently encountered a case of intracranial involvement of plasma cell myeloma. A 69-year-old man was hospitalized for headache and mental changes. Brain CT showed subdural hemorrhage caused by plasma cell myeloma. Plasma cell myeloma with intracranial involvement has poor prognosis, and the patient in this case died from acute complications, such as subdural hemorrhage. Based on this case report, it is suggested that more effective treatment regimens of plasma cell myeloma with intracranial involvement be developed. Moreover, a screening method and decision on the appropriate time for intracranial involvement are needed for plasma cell myeloma patients.
Abstract
Plasma cell myelomas generally manifest as bone or soft-tissue tumors with variable mass effects, pain, and infiltrative behavior. Extramedullary involvement occurs most commonly in the spleen, liver, lymph nodes, and kidneys, but intracranial involvement in plasma cell myeloma is a rare extramedullary manifestation. These authors recently encountered a case of intracranial involvement of plasma cell myeloma. A 69-year-old man was hospitalized for headache and mental changes. Brain CT showed subdural hemorrhage caused by plasma cell myeloma. Plasma cell myeloma with intracranial involvement has poor prognosis, and the patient in this case died from acute complications, such as subdural hemorrhage. Based on this case report, it is suggested that more effective treatment regimens of plasma cell myeloma with intracranial involvement be developed. Moreover, a screening method and decision on the appropriate time for intracranial involvement are needed for plasma cell myeloma patients.
참고문헌 (8)
- Wavre A, "Case study of intracerebral plasmacytoma as an initial presentation of multiple myeloma", Neuro Oncol, 9, pp.370~372 (2007)
- Cerase A, "Intracranial involvement in plasmacytomas and multiple myeloma: a pictorial essay", Neuroradiology, 50, pp.665~674 (2008)
- 유진영, "다발성골수종 환자에서 발병한 중추 신경계 골수종증 1예", 대한내과학회지, pp.S695~ (2009)
- 윤각원, "동종조혈모세포이식 후 발생한 중추신경계 골수종증", Blood Research, 43(3), pp.194~197 (2008), 대한혈액학회
- Gozzetti A, "Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients", Cancer, 118, pp.1574~1584 (2012)
- Kwon IS, "Multiple myeloma involved in the central nervous system", New Med J, 29, pp.47~54 (1986)
- 방해인, "A Case of Central Nervous System Myelomatosis with Complex Chromosome Aberrations", Annals of Laboratory Medicine, 30(4), pp.334~338 (2010), 대한진단검사의학회
- Brenner B, "Incidence, prognostic significance and therapeutic modalities of central nervous system involvement in multiple myeloma", Acta Haematol, 68, pp.77~83 (1982)