Effect of preoperative pregabalin on postoperative pain after gastrectomy
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain. Methods: Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period. Results: The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth. Conclusion: A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.
Abstract
Background: Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of pregabalin in resolving post-gastrectomy pain. Methods: Forty-four patients were randomized into two groups: a pregabalin group that received oral pregabalin (150 mg) 2 h before anesthetic induction, and a control group that received placebo tablets at the same time. Data on postoperative pain intensity (visual analog scale [VAS], at 30 min, 2 h, 4 h, and 24 h), consumption of fentanyl in patient-controlled analgesia (PCA), and the proportion of patients requiring rescue analgesics at different time intervals (0-2 h, 2-4 h, and 4-24 h) were collected during the 24 h postoperative period. Results: The VAS scores did not show significant differences at any time point and consumption of fentanyl in PCA and the proportion of patients requiring rescue analgesics did not differ between the two groups. The groups did not differ in the occurrence of dizziness, sedation, and dry mouth. Conclusion: A preoperative 150 mg dose of pregabalin exerts no effect on acute pain after gastrectomy.
참고문헌 (22)
- Apfelbaum JL, "Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged", Anesth Analg, 97, pp.534~540 (2003)[DOI]
- Rathmell JP, "Acute post-surgical pain management: a critical appraisal of current practice, December 2-4, 2005", Reg Anesth Pain Med, 31(4), pp.1~42 (2006)
- Finnerup NB, "The evidence for pharmacological treatment of neuropathic pain", Pain, 150, pp.573~581 (2010)[DOI]
- Rajappa GC, "Efficacy of pregabalin as premedication for post-operative analgesia in vaginal hysterectomy", Anesth Pain Med, 6, pp.e34591~ (2016)
- Hetta DF, "Analgesic efficacy of pregabalin in acute postmastectomy pain: placebo controlled dose ranging study", J Clin Anesth, 34, pp.303~309 (2016)[DOI]
- Cabrera Schulmeyer MC, "Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy", Obes Surg, 20, pp.1678~1681 (2010)[DOI]
- Buvanendran A, "Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial", Anesth Analg, 110, pp.199~207 (2010)[DOI]
- Julius D, "Molecular mechanisms of nociception", Nature, 413, pp.203~210 (2001)[DOI]
- Werner MU, "Prediction of postoperative pain: a systematic review of predictive experimental pain studies", Anesthesiology, 112, pp.1494~1502 (2010)[DOI]
- Kehlet H, "Persistent postsurgical pain: risk factors and prevention", Lancet, 367, pp.1618~1625 (2006)[DOI]
- Lavand'homme P, "Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery", Anesthesiology, 103, pp.813~820 (2005)[DOI]
- Seib RK, "Preoperative gabapentin for postoperative analgesia: a meta-analysis", Can J Anaesth, 53, pp.461~469 (2006)[DOI]
- Capdevila X, "Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients", Anesthesiology, 103, pp.1035~1045 (2005)[DOI]
- Tufanogullari B, "Dexmedetomidine infusion during laparoscopic bariatric surgery: the effect on recovery outcome variables", Anesth Analg, 106, pp.1741~1748 (2008)[DOI]
- Bjordal JM, "Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption. A meta-analysis with assessment of optimal treatment parameters for postoperative pain", Eur J Pain, 7, pp.181~188 (2003)[DOI]
- Kehlet H, "The value of "multimodal" or "balanced analgesia" in postoperative pain treatment", Anesth Analg, 77, pp.1048~1056 (1993)
- Moore RA, "Pregabalin for acute and chronic pain in adults", Cochrane Database Syst Rev, (3) (2009)
- Shneker BF, "Pregabalin: a new neuromodulator with broad therapeutic indications", Ann Pharmacother, 39, pp.2029~2037 (2005)[DOI]
- Agarwal A, "Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy", Br J Anaesth, 101, pp.700~704 (2008)[DOI]
- Jokela R, "A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy", Pain, 134, pp.106~112 (2008)[DOI]
- Paech MJ, "A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery", Anesth Analg, 105, pp.1449~1453 (2007)[DOI]
- Esmat IM, "Comparative study between paracetamol and two different doses of pregabalin on postoperative pain in laparoscopic cholecystectomy", Saudi J Anaesth, 9, pp.376~380 (2015)[DOI]