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Massive cerebral venous sinus thrombosis secondary to Graves' disease

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초록

Cerebral venous sinus thrombosis (CVT) is a rare cerebrovascular condition accounting for 0.5–1% of all types of strokes in the general population. Hyperthyroidism is associated with procoagulant and antifibrinolytic activity, thereby precipitating a hypercoagulable state that predisposes to CVT. We report the case of a 31-year-old Korean man with massive CVT and diagnosis of concomitant Graves’ disease at admission. Early diagnosis and prompt treatment of CVT are important to improve prognosis; therefore, CVT should be considered in the differential diagnosis in all patients with hyperthyroidism presenting with neurological symptoms.

Abstract

Cerebral venous sinus thrombosis (CVT) is a rare cerebrovascular condition accounting for 0.5–1% of all types of strokes in the general population. Hyperthyroidism is associated with procoagulant and antifibrinolytic activity, thereby precipitating a hypercoagulable state that predisposes to CVT. We report the case of a 31-year-old Korean man with massive CVT and diagnosis of concomitant Graves’ disease at admission. Early diagnosis and prompt treatment of CVT are important to improve prognosis; therefore, CVT should be considered in the differential diagnosis in all patients with hyperthyroidism presenting with neurological symptoms.

참고문헌 (11)

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  6. Jong-Uk Hwang, "The Role of Hyperthyroidism as the Predisposing Factor for Superior Sagittal Sinus Thrombosis", Journal of Cerebrovascular and Endovascular Neurosurgery, 14(3), pp.251~254 (2012), 대한뇌혈관외과학회[DOI]
  7. Merino M, "Thyro-toxicosis and cerebral venous sinus thrombosis, causality or chance alone?", Endocrinol Nutr, 59, pp.462~463 (2012)
  8. Migeot M, "Puerperal cerebral sinus venous thrombosis and acute hyperthyroidism in Graves’ disease", Acta Neurol Belg, 113, pp.331~333 (2013)
  9. Bensalah M, "Cerebral vein and sinus thrombosis and hyperthyrodism: a case report and a systematic review of the literature", Thromb Res, 128, pp.98~100 (2011)
  10. Squizzato A, "Thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review", J Clin Endocrinol Metab, 92, pp.2415~2420 (2007)
  11. Rosendaal FR, "Venous thrombosis: a multicausal disease", Lancet, 353, pp.1167~1173 (1999)

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