The Effect of Probiotic on Constipation in Rats
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background：Constipation is one of the most common disorders in Korea and Western countries. It may be related with life style, diet, physical activity, age, stress and gender, and particularly premenopausal women experience constipation more often than men due to the significant prolongation of the mean colonic transit in women. The aim of this study was to evaluate the effect of a probiotic on constipation in loperamide-induced constipated rats. Materials and Methods：The rats were divided into 3 groups. Constipation was induced by administration of loperamide for 5 days, and the excreted amount as well as the number of feces was observed. Lactic acid bacteria as a probiotic were administered orally every day for 5 days. Results：The results showed that loperamide administration induced severe experimental constipation in rats. The amount of feces was decreased and the number of pellets was increased by loperamide. The water content in the feces as a parameter of constipation was also decreased by loperamide. On the other hand, the dry weights of feces were not significantly different among the groups. It represents that the amount of food consumption might have been similar among the groups, and constipation was caused by delayed intestinal movement. Conclusion：Probiotic administration for 5 days in rats partly alleviated or prevented the constipation induced by loperamide.
Abstract
Background：Constipation is one of the most common disorders in Korea and Western countries. It may be related with life style, diet, physical activity, age, stress and gender, and particularly premenopausal women experience constipation more often than men due to the significant prolongation of the mean colonic transit in women. The aim of this study was to evaluate the effect of a probiotic on constipation in loperamide-induced constipated rats. Materials and Methods：The rats were divided into 3 groups. Constipation was induced by administration of loperamide for 5 days, and the excreted amount as well as the number of feces was observed. Lactic acid bacteria as a probiotic were administered orally every day for 5 days. Results：The results showed that loperamide administration induced severe experimental constipation in rats. The amount of feces was decreased and the number of pellets was increased by loperamide. The water content in the feces as a parameter of constipation was also decreased by loperamide. On the other hand, the dry weights of feces were not significantly different among the groups. It represents that the amount of food consumption might have been similar among the groups, and constipation was caused by delayed intestinal movement. Conclusion：Probiotic administration for 5 days in rats partly alleviated or prevented the constipation induced by loperamide.
참고문헌 (20)
- Talley NJ, "Definitions, epidemiology, and impact of chronic constipation", Rev Gastroenterol Disord, (Suppl 2), pp.S3~S10 (2004)
- Wald A, "A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation", Aliment Pharmacol Ther, 28(7), pp.917~930 (2008)
- Wald A, "Survey of laxative use by adults with self-defined constipation in South America and Asia: a comparison of 6 countries", Aliment Pharmacol Ther (2009)
- Sandler RS, "Bowel habits in young adults not seeking health care", Dig Dis Sci, 32(8), pp.841~845 (1987)
- Rendtorff RC, "Stool patterns of healthy adult males", Dis Colon Rectum, 10(3), pp.222~228 (1967)
- Thompson WG, "Functional bowel disorders in apparently healthy people", Gastroenterology, 79(2), pp.283~288 (1980)
- Drossman DA, "Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction", Gastroenterology, 83(3), pp.529~534 (1982)
- Everhart JE, "A longitudinal survey of self-reported bowel habits in the United States", Dig Dis Sci, 34(8), pp.1153~1162 (1989)
- Wynn SG, "Probiotics in veterinary practice", J Am Vet Med Assoc, 234(5), pp.606~613 (2009)
- Ouwehand AC, "Probiotics: an overview of beneficial effects", Antonie Van Leeuwenhoek, 82(1-4), pp.279~289 (2002)
- Higashikawa F, "Improvement of constipation and liver function by plant- derived lactic acid bacteria: A double-blind, randomized trial", Nutrition (2009)
- Thompson WG, "Functional bowel disorders and functional abdominal pain", Gut, 45(Suppl2), pp.1143~1147 (1999)
- Surrenti E, "Audit of constipation in a tertiary referral gastroenterology practice", Am J Gastroenterol, 90(9), pp.1471~1475 (1995)
- Heaton KW, "Defecation frequency and timing, and stool form in the general population: a prospective study", Gut, 33(6), pp.818~824 (1992)
- Preston DM, "Severe chronic constipation of young women with idiopathic slow transit constipation", Gut, 27(1), pp.41~48 (1986)
- Meier R, "Influence of age, gender, hormonal status and smoking habits on colonic transit time", Neurogastroenterol Motil, 7(4), pp.235~238 (1995)
- Hinds JP, "Does gender or the menstrual cycle affect colonic transit?", Am J Gastroenterol, 84(2), pp.123~126 (1989)
- Liem O, "Novel and alternative therapies for childhood constipation", Curr Gastroenterol Rep, 9(3), pp.214~218 (2007)
- Amenta M, "Diet and chronic constipation. Benefits of oral supplementation with symbiotic zir fos (Bifidobacterium longum W11 + FOS Actilight)", Acta Biomed, 77(3), pp.157~162 (2006)
- Fernandez-Banares F, "Nutritional care of the patient with constipation", Best Pract Res Clin Gastroenterol, 20(3), pp.575~587 (2006)