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코티졸, 알도스테론을 동시에 분비하는 부신피질암 1예

A Case of Adrenocortical Carcinoma Secreting Cortisol and Aldosterone

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초록

Adrenocortical carcinomas are rare and frequently aggressive tumors that may be functional (hormone-secreting) and may cause Cushing’s syndrome or virilization, or non-functional and manifest as an abdominal mass. This paper reports the case of a 77-year-old woman with cortisol- and aldosterone-secreting adrenal carcinoma. The patient complained of general weakness, a moon face, and weight gain. She also had hypokalemia and hypertension. Her endocrinological data showed excessive aldosterone production and non-suppressible cortisol production in a low-dose dexamethasone suppresion test. Her abdominal CT showed a right adrenal mass. She underwent right adrenalectomy, and her histology revealed the presence of adrenocortical carcinoma. After adrenalectomy, her hypokalemia returned to normal and she is being treated with hydrocortisone.

Abstract

Adrenocortical carcinomas are rare and frequently aggressive tumors that may be functional (hormone-secreting) and may cause Cushing’s syndrome or virilization, or non-functional and manifest as an abdominal mass. This paper reports the case of a 77-year-old woman with cortisol- and aldosterone-secreting adrenal carcinoma. The patient complained of general weakness, a moon face, and weight gain. She also had hypokalemia and hypertension. Her endocrinological data showed excessive aldosterone production and non-suppressible cortisol production in a low-dose dexamethasone suppresion test. Her abdominal CT showed a right adrenal mass. She underwent right adrenalectomy, and her histology revealed the presence of adrenocortical carcinoma. After adrenalectomy, her hypokalemia returned to normal and she is being treated with hydrocortisone.

참고문헌 (13)

  1. Roman S., "Adrenocortical carcinoma", Curr Opin Oncol, 18, pp.36~42 (2006)
  2. Ng L, "Adrenocortical carcinoma: diagnosis, evaluation and treatment", J Urol, 169, pp.5~11 (2003)
  3. Fassnacht M, "Adrenocortical carcinoma: a clinician’s update", Nat Rev Endocrinol, 7, pp.323~335 (2011)
  4. Bertherat J, "Pathogenesis of adrenocortical cancer", Best Pract Res Clin Endocrinol Metab, 23, pp.261~271 (2009)
  5. 최재호, "코르티졸, 안드로겐, 알도스테론을 동시에 분비하는 부신피질암 1예", Endocrinology and Metabolism, 26(3), pp.239~242 (2011), 대한내분비학회
  6. Kendrick ML, "Aldosterone-secreting adrenocortical carcinomas are associated with unique operative risks and outcomes", Surgery, 132, pp.1008~1011 (2002)
  7. 박근용, "쿠싱증후군과 원발성 알도스테론증을 동반한 부신피질선암 1예", Endocrinology and Metabolism, 19(4), pp.446~451 (2004), 대한내분비학회
  8. Fassnacht M, "Clinical management of adrenocortical carcinoma", Best Pract Res Clin Endocrinol Metab, 23, pp.273~289 (2009)
  9. Nomura K, "In vivo evidence of cortisol secretion by aldosterone-producing adenomas", Acta Endocrinol (Copenh), 106, pp.516~520 (1984)
  10. RapaportE, "Mortality in surgically treated adrenocortical tumors. II. review of cases reported for the 20 year period 1930-1949, inclusive", Postgrad Med, 11, pp.325~353 (1952)
  11. Brennan MF, "Adrenocortical carcinoma", CA Cancer J Clin, 37, pp.348~365 (1987)
  12. Stojadinovic A, "Adrenocortical carcinoma: clinical, morphologic, and molecular characterization", J Clin Oncol, 20, pp.941~950 (2002)
  13. Weiss LM, "Pathologic features of prognostic significance in adrenocortical carcinoma", Am J Surg Pathol, 13, pp.202~206 (1989)

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