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Superficial malignant peripheral nerve sheath tumor from recurrent neurofibroma in the abdominal wall of a patient without neurofibromatosis type 1

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초록

Malignant peripheral nerve sheath tumor (MPNST) is rare, accounting for 5–10% of all soft tissue sarcomas. MPNST is characteristically aggressive and has a poor prognosis. Fifty percent of patients with MPNST have neurofibromatosis type 1 (NF1). NF-associated MPNST occurs more often at younger ages than sporadic MPNST, but the survival difference is controversial. Superficial MPNST from a recurrent neurofibroma is extremely rare and only a limited number of cases have been reported in the literature. Herein, we report an unusual case of superficial MPNST from a recurrent neurofibroma in a patient without NF1.

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is rare, accounting for 5–10% of all soft tissue sarcomas. MPNST is characteristically aggressive and has a poor prognosis. Fifty percent of patients with MPNST have neurofibromatosis type 1 (NF1). NF-associated MPNST occurs more often at younger ages than sporadic MPNST, but the survival difference is controversial. Superficial MPNST from a recurrent neurofibroma is extremely rare and only a limited number of cases have been reported in the literature. Herein, we report an unusual case of superficial MPNST from a recurrent neurofibroma in a patient without NF1.

참고문헌 (16)

  1. 황인경, "Outcomes of Treatment for Malignant Peripheral Nerve Sheath Tumors: Different Clinical Features Associated with Neurofibromatosis Type 1", Cancer Research and Treatment, 49(3), pp.717~726 (2017), 대한암학회
  2. Farid M, "Malignant peripheral nerve sheath tumors", Oncologist, 19, pp.193~201 (2014)
  3. 김철한, "An Unusual Case of a Malignant Peripheral Nerve Sheath Tumor", Archives of Plastic Surgery, 40(3), pp.285~287 (2013), 대한성형외과학회
  4. Chen HJ, "Malignant peripheral nerve sheath tumor of the neck: transformation from a recurrent neurofibroma in a patient without neurofibromatosis", Tzu Chi Med J, 22, pp.195~199 (2010)
  5. 권유진, "췌장에 발생한 악성 말초신경초종양", 한국간담췌외과학회지, 12(4), pp.307~311 (2008), 한국간담췌외과학회
  6. Zhang M, "Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors", Nat Genet, 46, pp.1170~1172 (2014)
  7. Schaefer IM, "Malignant peripheral nerve sheath tumor (MPNST) arising in diffuse-type neurofibroma: clinicopathologic characterization in a series of 9 cases", Am J Surg Pathol, 39, pp.1234~1241 (2015)
  8. Allison KH, "Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis", Am J Clin Pathol, 124, pp.685~692 (2005)
  9. Feng CJ, "Superficial or cutaneous malignant peripheral nerve sheath tumor-clinical experience at Taipei Veterans General Hospital", Ann Plast Surg, 74(Suppl 2), pp.S85~S88 (2015)
  10. Thomas C, "Cutaneous malignant peripheral nerve sheath tumors", J Cutan Pathol, 36, pp.896~900 (2009)
  11. Njoumi N, "Solitary preperitoneal neurofibroma: a case report", BMC Res Notes, 8, pp.115~ (2015)
  12. Azani AB, "Sinonasal tract neurofibroma: a clinicopathologic series of 12 cases with a review of the literature", Head Neck Pathol, 9, pp.323~333 (2015)
  13. Boto J, "Solitary neurofibroma of the spermatic cord: a case report", J Radiol Case Rep, 9, pp.19~28 (2015)
  14. Schaefer IM, "Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics", Mod Pathol, 29, pp.4~13 (2016)
  15. Kang Y, "Diagnostic utility of SOX10 to distinguish malignant peripheral nerve sheath tumor from synovial sarcoma, including intraneural synovial sarcoma", Mod Pathol, 27, pp.55~61 (2014)
  16. Pekmezci M, "Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas", Mod Pathol, 28, pp.187~200 (2015)

관련 논문AI추천

Outcomes of Treatment for Malignant Peripheral Nerve Sheath Tumors: Different Clinical Features Associated with Neurofibromatosis Type 1김상겸, 김효선, 김효송, 서창옥, 신규호, 유철주, 한승민, 한정우, 황인경대한암학회 · Cancer Research and Treatment2017 · 제49권 제3호Malignant Peripheral Nerve Sheath Tumor in Neurofibromatosis Type I : Unusual Presentation of Intraabdominal or Intrathoracic Mass손상균, Dong Hwan Kim, jong Gwang Kim, Kyu Bo Lee, Woo Jin Sung, Young Hwan Kim대한내과학회 · The Korean Journal of Internal Medicine2005 · 제20권 제1호Malignant Peripheral Nerve Sheath Tumors of the Bilateral Adrenal Glands: Are They Metachronous Primary Tumors - A Case Report -박재홍, 조현이, 하승연대한병리학회 · Journal of Pathology and Translational Medicine2009 · 제43권 제5호Giant Plexiform Neurofibroma of the Perineum and Pelvic Cavity Manifesting as Segmental Neurofibromatosis김명화, 박명진, 박민기, 박병철, 성기현, 최미수, 홍승필대한피부과학회 · Annals of Dermatology2019 · 제31권 제3호A Rare Case of Aggressive Melanotic Schwannoma Occurred in Spinal Nerve of a 59-Year-Old Male구성욱, 김성준, 김세훈, 김지섭, 서자영, 차윤진, 차현서, 최성은대한병리학회 · Journal of Pathology and Translational Medicine2017 · 제51권 제5호Malignant Peripheral Nerve Sheath Tumor Presenting as a Chronic Parotid Gland Mass: A Case ReportCzarina Angelli L. Anastacio, Ida Marie Tabangay-Lim, Wilson C. Zuñiga대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2025 · 제68권 제11호

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