갑상선 경계성 종양: 외과의사의 관점
Borderline Thyroid Tumors: a Surgeon’s Perspectives
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Borderline thyroid tumors are composed of hyalinizing trabecular tumor (HTT), well differentiated tumor of uncertain malignant potential (WDT-UMP), follicular tumor of uncertain malignant potential (FT-UMP) and non-invasive follicular tumor with papillary like nuclear feature (NIFTP) by World Health Organization (WHO) definition. They have different pathological feature from each other. However, it is difficult to diagnose with diagnostic imaging, fine needle aspiration (FNA) or core biopsy preoperatively. Thus, the diagnosis is usually made after diagnostic lobectomy. Main surgical concerns about borderline tumor are not performing total thyroidectomy because of relatively indolent nature of these tumors. Unfortunately, some of these tumors can be diagnosed as malignant tumor preoperatively. The other surgical concern is performing completion thyroidectomy or not after diagnostic lobectomy. Decision making is difficult even though it is generally considered that lobectomy alone is enough. In this article, we will discuss clinical features of borderline malignant tumors and surgical strategy for these tumors.
Abstract
Borderline thyroid tumors are composed of hyalinizing trabecular tumor (HTT), well differentiated tumor of uncertain malignant potential (WDT-UMP), follicular tumor of uncertain malignant potential (FT-UMP) and non-invasive follicular tumor with papillary like nuclear feature (NIFTP) by World Health Organization (WHO) definition. They have different pathological feature from each other. However, it is difficult to diagnose with diagnostic imaging, fine needle aspiration (FNA) or core biopsy preoperatively. Thus, the diagnosis is usually made after diagnostic lobectomy. Main surgical concerns about borderline tumor are not performing total thyroidectomy because of relatively indolent nature of these tumors. Unfortunately, some of these tumors can be diagnosed as malignant tumor preoperatively. The other surgical concern is performing completion thyroidectomy or not after diagnostic lobectomy. Decision making is difficult even though it is generally considered that lobectomy alone is enough. In this article, we will discuss clinical features of borderline malignant tumors and surgical strategy for these tumors.
참고문헌 (17)
- Lloyd RV, "Other encapsulated follicular patterned tumours", pp.75~80 (2017), IARC Publication
- Smith NR, "Hyalinizing trabecular tumour: review and new insights into the molecular biology", J Otolaryngol Head Neck Surg, 41(1), pp.30~34 (2012)
- 장현식, "Hyalinizing trabecular tumor of the thyroid: diagnosis of a rare tumor using ultrasonography, cytology, and intraoperative frozen sections", ULTRASONOGRAPHY, 35(2), pp.131~139 (2016), 대한초음파의학회
- Lee S, "The ultrasonography features of hyalinizing trabecular tumor of the thyroid are more consistent with its benign behavior than cytology or frozen section readings", Thyroid, 21(3), pp.253~259 (2011)
- Choi WJ, "The ultrasonography features of hyalinizing trabecular tumor of the thyroid gland and the role of fine needle aspiration cytology and core needle biopsy in its diagnosis", Acta Radiol, 56(9), pp.1113~1118 (2015)
- Howard BE, "Hyalinizing trabecular tumor masquerading as papillary thyroid carcinoma on fine-needle aspiration", ORL J Otorhinolaryngol Relat Spec, 75(6), pp.309~313 (2013)
- Saglietti C, "Hyalinizing trabecular tumour of the thyroid: Fine-needle aspiration cytological diagnosis and correlation with histology", J Clin Pathol, 70(8), pp.641~647 (2017)
- Salvatore G, "Molecular profile of hyalinizing trabecular tumours of the thyroid: High prevalence of RET", PTC rearrangements and absence of B-raf and N-ras point mutations, 2005, pp.41(5), 816~821
- Hofman V, "Thyroid tumours of uncertain malignant potential:Frequency and diagnostic reproducibility", Virchows Arch, 455(1), pp.21~33 (2009)
- Liu Z, "Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well-differentiated tumor of uncertain malignant potential: A morphological, immunohistochemical, and molecular appraisal", Cancer Sci, 102(1), pp.288~294 (2011)
- Piana S, "Encapsulated well-differentiated follicular-patterned thyroid carcinomas do not play a significant role in the fatality rates from thyroid carcinoma", Am J Surg Pathol, 34(6), pp.868~872 (2010)
- Baser H, "Comparing clinicopathologic and radiographic findings between TT-UMP, classical, and non-encapsulated follicular variants of papillary thyroid carcinomas", Endocr Pathol, 27(3), pp.233~242 (2016)
- Nechifor-Boila A, "Thyroid tumors of uncertain malignant potential: morphologic and imunohistochemical analysis of 29 cases", Pathol Res Pract, 211(4), pp.320~325 (2015)
- Haugen BR, "2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer", Thyroid, 26(1), pp.1~133 (2016)
- Kakudo K, "How to handle borderline", precursor thyroid tumors in management of patients with thyroid nodules, 2018, pp.7(Suppl 1), S8~S18
- Wienhold R, "The management of thyroid nodules: a retrospective analysis of health insurance data", Dtsch Arztebl Int, 110(49), pp.827~834 (2013)
- Nikiforov YE, "Impact of the multi-gene ThyroSeq nextgeneration sequencing assay on cancer diagnosis in thyroid nodules with atypia of undetermined significance", follicular lesion of undetermined significance cytology, 2015, pp.25(11), 1217~1223