본문 바로가기
KERD
논문KCI 등재

갑상선유두암에서 전이림프절에 대한 적절한 수술 범위

Optimal Neck Dissection Extent for Metastatic Lymph Nodes in Papillary Thyroid Cancer

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류의학일반

초록

Papillary thyroid cancer (PTC) has a good prognosis, but the frequency of regional lymph node metastasis isreported to be up to 90%. In most patients with PTC, nodal metastasis occurs in a stepwise fashion, withmetastasis beginning in the central cervical compartment, continuing to the ipsilateral cervical compartment. Thereare many controversies about the necessity of prophylactic central neck dissection (CND) and extent of therapeuticCND for lymph node metastasis. Ipsilateral CND with intraoperative frozen biopsy in PTC is a very sensitive anduseful tool for the evaluation of nodal status in the central compartment. The right upper para-esophageal lymphnodes should be removed during dissection in patients with right paratracheal lymph node metastasis. Prophylacticlateral neck dissection (LND) is not recommended, and optimal extent of therapeutic LND is still controversial. Further studies on factors and clinical implications related to suprasternal lymph node metastasis are needed.

Abstract

Papillary thyroid cancer (PTC) has a good prognosis, but the frequency of regional lymph node metastasis isreported to be up to 90%. In most patients with PTC, nodal metastasis occurs in a stepwise fashion, withmetastasis beginning in the central cervical compartment, continuing to the ipsilateral cervical compartment. Thereare many controversies about the necessity of prophylactic central neck dissection (CND) and extent of therapeuticCND for lymph node metastasis. Ipsilateral CND with intraoperative frozen biopsy in PTC is a very sensitive anduseful tool for the evaluation of nodal status in the central compartment. The right upper para-esophageal lymphnodes should be removed during dissection in patients with right paratracheal lymph node metastasis. Prophylacticlateral neck dissection (LND) is not recommended, and optimal extent of therapeutic LND is still controversial. Further studies on factors and clinical implications related to suprasternal lymph node metastasis are needed.

참고문헌 (41)

  1. Nixon IJ, "Changing trends in well differentiated thyroid carcinoma over eight decades", Int J Surg, 10(10), pp.618~623 (2012)
  2. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, "Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer", Thyroid, 19(11), pp.1167~1214 (2009)
  3. Cooper DS, "Management guidelines for patients with thyroid nodules and differentiated thyroid cancer", Thyroid, 16(2), pp.109~142 (2006)
  4. Haugen BR, "2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer", Thyroid, 26(1), pp.1~133 (2016)
  5. Oda H, "Incidences of unfavorable events in the management of low-risk papillary microcarcinoma of the thyroid by active surveillance versus immediate surgery", Thyroid, 26(1), pp.150~155 (2016)
  6. Cranshaw IM, "Micrometastases in thyroid cancer. An important finding?", An important finding? Surg Oncol, 17(3), pp.253~258 (2008)
  7. Liu LS, "The incidence and risk factors for central lymph node metastasis in cN0 papillary thyroid microcarcinoma : a meta-analysis", Eur Arch Otorhinolaryngol, 274(3), pp.1327~1338 (2017)
  8. Randolph GW, "The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension", Thyroid, 22(11), pp.1144~1152 (2012)
  9. Lee YS, "Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer", Head Neck, 36(6), pp.887~891 (2014)
  10. Machens A, "Pattern of nodal metastasis for primary and reoperative thyroid cancer", World J Surg, 26(1), pp.22~28 (2002)
  11. 이가희, "2016년 대한갑상선학회 갑상선결절 및 암 진료 권고안 개정안", International Journal of Thyroidology, 9(2), pp.59~126 (2016), 대한갑상선학회
  12. American Thyroid Association Surgery Working Group, "Consensus statement on the terminology and classification of central neck dissection for thyroid cancer", Thyroid, 19(11), pp.1153~1158 (2009)
  13. Robbins KT, "Consensus statement on the classification and terminology of neck dissection", Arch Otolaryngol Head Neck Surg, 134(5), pp.536~538 (2008)
  14. Shin SC, "Is prophylactic central node dissection omissible?", Korean J Head Neck Oncol, 34(1), pp.1~7 (2018)
  15. Kim E, "Preoperative diagnosis of cervical metastatic lymph nodes in papillary thyroid carcinoma : comparison of ultrasound, computed tomography, and combined ultrasound with computed tomography", Thyroid, 18(4), pp.411~418 (2008)
  16. Wada N, "Lymph node metastasis from 259 papillary thyroid microcarcinomas : frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection", Ann Surg, 237(3), pp.399~407 (2003)
  17. Costa S, "Role of prophylactic central neck dissection in cN0 papillary thyroid cancer", Acta Otorhinolaryngol Ital, 29(2), pp.61~69 (2009)
  18. Zhao W, "The effect of prophylactic central neck dissection on locoregional recurrence in papillary thyroid cancer after total thyroidectomy : a systematic review and meta-analysis : pCND for the locoregional recurrence of papillary thyroid cancer", Ann Surg Oncol, 24(8), pp.2189~2198 (2017)
  19. 안순현, "The Effect of Prophylactic Central Neck Dissection During Hemithyroidectomy on Locoregional Recurrence in Patients With Papillary Thyroid Carcinoma: A Meta-Analysis", Clinical and Experimental Otorhinolaryngology, 13(2), pp.194~202 (2020), 대한이비인후과학회[DOI]
  20. Chisholm EJ, "Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone", Laryngoscope, 119(6), pp.1135~1139 (2009)
  21. Lang BH, "A systematic review and meta-analysis of prophylactic central neck dissection on short-term locoregional recurrence in papillary thyroid carcinoma after total thyroidectomy", Thyroid, 23(9), pp.1087~1098 (2013)
  22. Lee YS, "Current trends of practical issues concerning micropapillary thyroid carcinoma: the Korean Society of Thyroid-Head and Neck Surgery", Medicine(Baltimore), 96(45), pp.e8596~ (2017)
  23. Giordano D, "Complications of central neck dissection in patients with papillary thyroid carcinoma : results of a study on 1087 patients and review of the literature", Thyroid, 22(9), pp.911~917 (2012)
  24. Lee J, "Clinical value of lymph node ratio integration with the 8(th)edition of the UICC TNM classification and 2015 ATA risk stratification systems for recurrence prediction in papillary thyroid cancer", Sci Rep, 9(1), pp.13361~ (2019)
  25. 최성용, "Metastatic Lymph Node Ratio of Central Neck Compartment Has Predictive Values for Locoregional Recurrence in Papillary Thyroid Microcarcinoma", Clinical and Experimental Otorhinolaryngology, 9(1), pp.75~79 (2016), 대한이비인후과학회
  26. Agrawal N, "Indications and extent of central neck dissection for papillary thyroid cancer : an American Head and Neck Society consensus statement", Head Neck, 39(7), pp.1269~1279 (2017)
  27. Yan B, "Risk factors for contralateral central lymph node metastasis in unilateral cN0papillary thyroid carcinoma : a meta-analysis", Int J Surg, 59, pp.90~98 (2018)
  28. Lim YS, "Frozen biopsy of central compartment in papillary thyroid cancer : quantitative nodal analysis", Head Neck, 35(9), pp.1319~1322 (2013)
  29. 이원용, "갑상선 유두암에서의 논쟁 : 전통적 갑상선 절제술", 임상이비인후과, 24(2), pp.156~162 (2013), 대한이비인후과학회 부산,울산,경남 지부회[DOI]
  30. Lee BJ, "Metastasis of right upper para-esophageal lymph nodes in central compartment lymph node dissection of papillary thyroid cancer", World J Surg, 33(10), pp.2094~2098 (2009)
  31. Park YM, "Predictive factors of right paraesophageal lymph node metastasis in papillary thyroid carcinoma : single center experience and meta-analysis", PLoS One, 12(5), pp.e0177956~ (2017)
  32. Kim D, "Right posterior paratracheal lymph nodes metastasis is one of the predictive factors in right-sided papillary thyroid carcinoma", Surgery, 166(6), pp.1154~1159 (2019)
  33. Lim YS, "Lateral cervical lymph node metastases from papillary thyroid carcinoma : predictive factors of nodal metastasis", Surgery, 150(1), pp.116~121 (2011)
  34. Mulla MG, "Lateral cervical lymph node metastases in papillary thyroid cancer: a systematic review of imaging-guided and prophylactic removal of the lateral compartment", Clin Endocrinol(Oxf), 77(1), pp.126~131 (2012)
  35. Stack BC Jr, "American Thyroid Association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer", Thyroid, 22(5), pp.501~508 (2012)
  36. Caron NR, "Selective modified radical neck dissection for papillary thyroid cancer-is level I, II and V dissection always necessary?", World J Surg, 30(5), pp.833~840 (2006)
  37. Won HR, "Optimal extent of lateral neck dissection for well-differentiated thyroid carcinoma with metastatic lateral neck lymph nodes : a systematic review and meta-analysis", Oral Oncol, 87, pp.117~125 (2018)
  38. Lee BJ, "Level IIb lymph node metastasis in neck dissection for papillary thyroid carcinoma", Arch Otolaryngol Head Neck Surg, 133(10), pp.1028~1030 (2007)
  39. Kim SK, "Should level V be routinely dissected in N1b papillary thyroid carcinoma?", Thyroid, 27(2), pp.253~260 (2017)
  40. Sun G, "Lymph node metastasis between sternocleidomastoid and sternohyoid muscle in clinically node-positive papillary thyroid carcinoma", Head Neck, 35(8), pp.1168~1170 (2013)
  41. Yu ST, "Lymph node metastasis in suprasternal space in pathological node-positive papillary thyroid carcinoma", Eur J Surg Oncol, 45(11), pp.2086~2089 (2019)

관련 논문AI추천

이 간행물의 다른 논문 (14건)