Rare Concurrence of Triple Primary Thyroid Cancer: A Patient of Papillary Carcinoma, Follicular Carcinoma, and Primary Lymphoma of the Thyroid
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
We report a rare case of co-occurrence of papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC) and primary thyroid lymphoma. A 55-year-old woman presented with a large mass in left lobe of thyroid, biopsy confirmed diffuse large B-cell lymphoma. After 4 cycles of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisolone chemotherapy, positron emission tomography scan revealed markedly decreased in size, but still present. Repeated ultrasonography-guided gun biopsies of 2 lesions indicated Hurthle cell neoplasm. After total thyroidectomy and bilateral central lymph node dissection, residual hypermetabolic lesion of left lobe was determined to be FTC and right lower lesion to be nodular hyperplasia. Besides, a PTC was incidentally detected in left lobe. If there are multiple nodular lesions at diagnosis or there is insufficient response after 1st line chemotherapy for primary thyroid lymphoma, each lesion should be biopsied to confirm its pathological type.
Abstract
We report a rare case of co-occurrence of papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC) and primary thyroid lymphoma. A 55-year-old woman presented with a large mass in left lobe of thyroid, biopsy confirmed diffuse large B-cell lymphoma. After 4 cycles of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisolone chemotherapy, positron emission tomography scan revealed markedly decreased in size, but still present. Repeated ultrasonography-guided gun biopsies of 2 lesions indicated Hurthle cell neoplasm. After total thyroidectomy and bilateral central lymph node dissection, residual hypermetabolic lesion of left lobe was determined to be FTC and right lower lesion to be nodular hyperplasia. Besides, a PTC was incidentally detected in left lobe. If there are multiple nodular lesions at diagnosis or there is insufficient response after 1st line chemotherapy for primary thyroid lymphoma, each lesion should be biopsied to confirm its pathological type.
참고문헌 (14)
- Sipos JA, "Thyroid cancer epidemiology and prognostic variables", Clin Oncol (R Coll Radiol), 22(6), pp.395~404 (2010)
- Cheng V, "Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto's thyroiditis", Thyroid, 22(6), pp.647~650 (2012)
- Cakir M, "A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma", Ann Afr Med, 12(3), pp.188~190 (2013)
- Graff-Baker A, "Prognosis of primary thyroid lymphoma: demographic, clinical, and pathologic predictors of survival in 1,408 cases", Surgery, 146(6), pp.1105~1115 (2009)
- Doria R, "Thyroid lymphoma. The case for combined modality therapy", Cancer, 73(1), pp.200~206 (1994)
- Meyer-Rochow GY, "Surgical trends in the management of thyroid lymphoma", Eur J Surg Oncol, 34(5), pp.576~580 (2008)
- Mack LA, "An evidence-based approach to the treatment of thyroid lymphoma", World J Surg, 31(5), pp.978~986 (2007)
- Noureldine SI, "Association of Hashimoto's thyroiditis and thyroid cancer", Curr Opin Oncol, 27(1), pp.21~25 (2015)
- Kim KW, "Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto's thyroiditis", Head Neck, 33(5), pp.691~695 (2011)
- Mian M, "Early-stage diffuse large B cell lymphoma of the head and neck: clinico-biological characterization and 18 year follow-up of 488 patients (IELSG 23 study)", Ann Hematol (2013)
- Stein SA, "Primary thyroid lymphoma: a clinical review", J Clin Endocrinol Metab, 98(8), pp.3131~3138 (2013)
- Eccles A, "Thyroid lymphoma incidentally detected by 18F-fluorocholine (FCH) PET", CT, 2013, pp.38(9), 755~757
- Szczepanek-Parulska E, "Thyroid nodule as a first manifestation of Hodgkin lymphoma-report of two cases and literature review", Diagn Pathol, 8, pp.116~ (2013)
- Diaconescu MR, "Unusual malignant tumors of the thyroid gland", Chirurgia (Bucur), 108(4), pp.482~489 (2013)