제6기 국민건강영양조사 자료를 이용한 요중 요오드 농도와 갑상선 과산화효소항체의 분석
Urinary Iodine Concentration and Thyroid Peroxidase Antibodies in the Korean Population Using Korea National Health and Nutrition Examination Survey VI
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Background and Objectives: This study was planned to investigate the relationship between iodine intake andthyroid peroxidase antibody in Korean population. Materials and Methods: We used the data of the 6th KoreaNational Health and Nutrition Examination Survey from 2013 to 2015. A total of 6564 subjects who had thedata of thyroid function test were included. We analyzed urinary iodine concentration and thyroid peroxidaseantibody using the complex sample method. Univariate and multivariate analysis were performed according toclinical factors and thyroid function tests. Results: In the multivariate analysis, the thyroid peroxidase antibodypositivity was not related to urinary iodine concentration in the total group (p=0.102), male group (p=0.245)and female group (p=0.098). The urinary iodine concentration was associated with thyroid stimulating hormone(TSH) (p=0.001) and free T4 (p=0.001) but not associated with thyroid peroxidase antibody (p=0.218). Whenhigh TSH group was divided into the positive and negative thyroid peroxidase antibody, high TSH group withnegative thyroid peroxidase antibody increased according to increasing urinary iodine concentration (p＜0.001). But there was no difference in the high TSH group with positive thyroid peroxidase antibody (p=0.826). Conclusion: This study did not show a statistically significant relationship between urinary iodine concentrationand thyroid peroxidase antibody. As urinary iodine concentration increased, thyroid function was decreased onlyin the negative thyroid peroxidase antibody group. This confirmed that the increased urinary iodine concentrationcaused hypothyroidism which was not associated with thyroid peroxidase antibody.
Abstract
Background and Objectives: This study was planned to investigate the relationship between iodine intake andthyroid peroxidase antibody in Korean population. Materials and Methods: We used the data of the 6th KoreaNational Health and Nutrition Examination Survey from 2013 to 2015. A total of 6564 subjects who had thedata of thyroid function test were included. We analyzed urinary iodine concentration and thyroid peroxidaseantibody using the complex sample method. Univariate and multivariate analysis were performed according toclinical factors and thyroid function tests. Results: In the multivariate analysis, the thyroid peroxidase antibodypositivity was not related to urinary iodine concentration in the total group (p=0.102), male group (p=0.245)and female group (p=0.098). The urinary iodine concentration was associated with thyroid stimulating hormone(TSH) (p=0.001) and free T4 (p=0.001) but not associated with thyroid peroxidase antibody (p=0.218). Whenhigh TSH group was divided into the positive and negative thyroid peroxidase antibody, high TSH group withnegative thyroid peroxidase antibody increased according to increasing urinary iodine concentration (p＜0.001). But there was no difference in the high TSH group with positive thyroid peroxidase antibody (p=0.826). Conclusion: This study did not show a statistically significant relationship between urinary iodine concentrationand thyroid peroxidase antibody. As urinary iodine concentration increased, thyroid function was decreased onlyin the negative thyroid peroxidase antibody group. This confirmed that the increased urinary iodine concentrationcaused hypothyroidism which was not associated with thyroid peroxidase antibody.
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