Changing Trends of Thyroid Cancer Clinical Characteristics and Treatment Pattern in South Korea: Insights from an Institutional Database and the Korean Cancer Center Registry Database
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Background and Objectives: To analyze the clinical trends and treatment patterns of thyroid cancer in the recent decade in South Korea. Materials and Methods: Two distinctive datasets, a single institutional database from 2009 to 2021 of differentiated thyroid cancer (DTC) patients (n=3145) and a nationwide database of the Korean Cancer Center Registry (KCCR) from 2005 to 2019 for patients (n=414,828) with all types of thyroid cancer, were analyzed. Annual incidence, the extent of thyroidectomy and neck dissection, T and N stages, and postoperative radioactive iodine (RAI) were investigated and descriptively presented. Results: The institutional database demonstrated that the annual cases of DTC surgeries suddenly dropped in 2014, coinciding with a social debate on overdiagnosis in South Korea. Due to changes in the staging manual and management guidelines during the study period, lobectomy has been preferred more than total thyroidectomy and the number of anterior compartment neck dissections has decreased. However, cases with lateral neck dissection and T4 stage gradually increased, suggesting that social issue did not influence the incidence of advanced thyroid diseases. The KCCR database also supported a similar phenomenon that showed a recent increase in localized and regional disease after a shock from social controversy. Conclusion: Our institutional and KCCR data findings collectively indicate a steady incidence in localized and regional thyroid cancer after the initial drop triggered by the 2014 controversy in South Korea.
Abstract
Background and Objectives: To analyze the clinical trends and treatment patterns of thyroid cancer in the recent decade in South Korea. Materials and Methods: Two distinctive datasets, a single institutional database from 2009 to 2021 of differentiated thyroid cancer (DTC) patients (n=3145) and a nationwide database of the Korean Cancer Center Registry (KCCR) from 2005 to 2019 for patients (n=414,828) with all types of thyroid cancer, were analyzed. Annual incidence, the extent of thyroidectomy and neck dissection, T and N stages, and postoperative radioactive iodine (RAI) were investigated and descriptively presented. Results: The institutional database demonstrated that the annual cases of DTC surgeries suddenly dropped in 2014, coinciding with a social debate on overdiagnosis in South Korea. Due to changes in the staging manual and management guidelines during the study period, lobectomy has been preferred more than total thyroidectomy and the number of anterior compartment neck dissections has decreased. However, cases with lateral neck dissection and T4 stage gradually increased, suggesting that social issue did not influence the incidence of advanced thyroid diseases. The KCCR database also supported a similar phenomenon that showed a recent increase in localized and regional disease after a shock from social controversy. Conclusion: Our institutional and KCCR data findings collectively indicate a steady incidence in localized and regional thyroid cancer after the initial drop triggered by the 2014 controversy in South Korea.
참고문헌 (28)
- Davies L, "American Association of Clinical Endocrinologists and American College of Endocrinology Disease State Clinical Review : the increasing incidence of thyroid cancer", Endocr Pract, 21(6), pp.686~696 (2015)
- Vaccarella S, "The impact of diagnostic changes on the rise in thyroid cancer incidence : a population-based study in selected high-resource countries", Thyroid, 25(10), pp.1127~1136 (2015)
- Vaccarella S, "Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis", N Engl J Med, 375(7), pp.614~617 (2016)
- Udelsman R, "The epidemic of thyroid cancer in the United States : the role of endocrinologists and ultrasounds", Thyroid, 24(3), pp.472~479 (2014)
- Ahn HS, "Korea's thyroid-cancer"epidemic"--screening and overdiagnosis", N Engl J Med, 371(19), pp.1765~1767 (2014)
- Davies L, "Increasing incidence of thyroid cancer in the United States, 1973-2002", JAMA, 295(18), pp.2164~2167 (2006)
- Brito JP, "Is there really an increased incidence of thyroid cancer?", Curr Opin Endocrinol Diabetes Obes, 21(5), pp.405~408 (2014)
- Li M, "Global trends in thyroid cancer incidence and the impact of overdiagnosis", Lancet Diabetes Endocrinol, 8(6), pp.468~470 (2020)
- Dal Maso L, "The impact of overdiagnosis on thyroid cancer epidemic in Italy, 1998-2012", Eur J Cancer, 94, pp.6~15 (2018)
- Lee SH, "Trends analysis of characteristics of thyroid cancer patients in one medical center", J Korean Endocr Soc, 23(1), pp.35~43 (2008)
- Rogers WA, "Ethical issues raised by thyroid cancer overdiagnosis : a matter for public health?", Bioethics, 31(8), pp.590~598 (2017)
- Ahn HS, "South Korea's thyroid-cancer"Epidemic"--turning the tide", N Engl J Med, 373(24), pp.2389~2390 (2015)
- Haugen BR, "2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer : the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer", Thyroid, 26(1), pp.1~133 (2016)
- Amin MB, "AJCC cancer staging manual" (2017), Springer International Publishing
- Jung KW, "Cancer statistics in Korea : incidence, mortality, survival, and prevalence in 2016", Cancer Res Treat, 51(2), pp.417~430 (2019)
- World Health Organization, "ICD-10 : International statistical classification of diseases and related health problems" (2004), World Health Organization
- Singer PA, "Treatment guidelines for patients with thyroid nodules and well-differentiated thyroid cancer. American Thyroid Association", Arch Intern Med, 156(19), pp.2165~2172 (1996)
- Zaridze D, "Thyroid cancer overdiagnosis revisited", Cancer Epidemiol, 74, pp.102014~ (2021)
- Panato C, "Thyroid cancer incidence in india between 2006 and 2014 and impact of overdiagnosis", J Clin Endocrinol Metab, 105(8), pp.2507~2514 (2020)
- Oh CM, "Decreasing trends in thyroid cancer incidence in South Korea : what happened in South Korea?", Cancer Med, 10(12), pp.4087~4096 (2021)
- Jung CK, "Re-increasing trends in thyroid cancer incidence after a short period of decrease in Korea : reigniting the debate on ultrasound screening", Endocrinol Metab(Seoul), 37(5), pp.816~818 (2022)
- Megwalu UC, "Thyroid cancer incidence and mortality trends in the United States : 2000-2018", Thyroid, 32(5), pp.560~570 (2022)
- Park JO, "Guideline for the surgical management of locally invasive differentiated thyroid cancer from the Korean Society of Head and Neck Surgery", Clin Exp Otorhinolaryngol, 16(1), pp.1~19 (2023)
- Dedhia PH, "Physician perspectives of overdiagnosis and overtreatment of low-risk papillary thyroid cancer in the US", JAMA Netw Open, 5(4), pp.e228722~ (2022)
- Tuttle RM, "Updated American Joint Committee on Cancer", Tumor-Node-Metastasis staging system for differentiated and anaplastic thyroid cancer(eighth edition) : what changed and why?, 2017, pp.27(6), 751~756
- Pasqual E, "Trends in the management of localized papillary thyroid carcinoma in the United States(2000-2018)", Thyroid, 32(4), pp.397~410 (2022)
- Collins RA, "Urban and rural surgical practice patterns for papillary thyroid carcinoma", Thyroid, 33(7), pp.849~857 (2023)
- Shaha AR, "Current controversies in the management of neck node metastasis in differentiated thyroid cancer", J Cancer Metastasis Treat, 9, pp.22~ (2023)