실험적으로 유발된 토끼 상악동염에서 중비도상악동개방술이 비점막의 섬모운동횟수 및 병리조직학적 형태에 미치는 영향

Abstract

Background and Objectives：The aim of this study was to observe the effects of midle meatal antrostomy (MMA) on ciliary beat frequency (CBF) and histopathology of the nasal mucosa in experimentally induced maxillary sinusitis in rabits. Materials and Method：Maxillary sinusitis was induced in both maxillary sinuses (MSs) of 30 Pasturellapartially occluding the natural ostium and inoculating with P. aeruginosa. After 4 weeks, the MS and inferior turbinate mucosae were obtained in 5 rabits. In the remaining 25 rabbits, the ostia were reopened. Five rabbits were sacrificed 2, 4, 6, 8, and 12 we-eks after MMA, respectively and the MS and inferior turbinate mucosae were obtained. Another 5 normal rabbits were used as a control group. CBF was measured by video-computerized analysis. Degree of inflammation in histopathology was graded using ups. Results：CBF of the MS mucosa significantly improved after MA in a time-dependent patern, but did not reach a normal level even after 12 weeks. CBF of the inferior turbinate mucosa significantly improved after MMA in a time-dependent pattern, and reached a normal level after 12 weeks. Inflammation scores of the MS and inferior turbinate mucosae were significantly decreased after MMA in a time-dependent pattern. However, they did not reach a normal level of the control group even after 12 weks. Conclusion：MMA can improve not only the primary inflammation of the MS mucosa but also functionally and morphologica-lly improve the secondarily developed inflamation of the nasal mucosa in experimentaly induced maxillary sinusitis in rabbits. (Korean J Otolaryngol 2003 ;46 :222-9)