Artecollⓡ Restylaneⓡ 성대내 주입술 후 조직학적 변화 및성대점막 진동 양상：생체 동물 실험

Abstract

Background and Objectives：The aims of this study are to introduce Artecoll and Restaylane, that have been available for facialaugmentation, as new materials for injection laryngoplasty, to investigate the mucosal wave of true vocal folds after the injectionof these two materials into the true vocal fold, and to assess its biocompatibility and durability. Subjects and Method：Aftercomplete paralysisof the right recurrent laryngeal nerve of 6 Beagle dogs, the dogs were divided into the Artecoll injection groupand the Restylane injection group, and Artecoll or Restylane was injected into vocalis muscle and vocal ligament. The recurrentlaryngeal nerve of the opposite side was stimulated, the posterior commissure was sutured, and the mucosal wave of true vocalfolds was examined by stroboscopy in in vivo canine study 1, 3, and 6 months after the injection. And, histopathological changeof the injected materials after total laryngectomy wasexamined by hematoxylin and eosin (H & E) staining and masson trichromestaining. Results：In both the Artecoll injection and the Restylane injection groups, the mucosal wave of true vocal folds wasdetected by stroboscopic examination until 6 months after the injection, and the difference of the mucosal wave of true vocal foldsbetween these two groups was difficult to detect. Histological studies revealed that the injected materials remained in the vocalligament and vocalis muscle and theses two materials were resorbed with time, Artecoll showing less resorption. These twomaterials were biocompatible and, particularly, Restylane showed less foreign body reaction. Conclusion：Since both Artecolland Restylane are biocompatible and durable, they areconsidered as the suitable material for injection larygoplasty, and additionallong-term studies are required.