타액선 악성 종양에서 세침흡인검사 및 동결절편검사의 유용성
Efficacy of Fine Needle Aspiration Biopsy and Frozen Section Biopsyin Salivary Gland Malignancies
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Abstract
Background and Objectives：The aim of this study was to investigate the efficacy of fine needle aspiration biopsy (FNAB)and frozen section biopsy in salivary gland malignancies. Subjects and Method：From January 1995 through December 2004,462 patients underwent operation for salivary gland mass. Of these patients, FNABs and frozen section biopsies were performedin 262 and 241 patients, respectively. The medical and pathologic reports were reviewed retrospectively. Malignancies were foundin 57 patients. Results：The sensitivity and the specificity of FNAB to detect salivary gland malignancies were 50.9% and 94.1%,respectively. For the frozen section biopsy, the sensitivity and specificity rose to 90.7% and 99.0%, respectively. When the examinationperiod was divided into period 1 (Jan, 1995-Dec, 1999) and period 2 (Jan, 2000-Dec, 2004), sensitivity showed asignificant increase from 33.3% to 57.1%. With respect to pathologic types of the tumors, the sensitivity of FNAB was high inadenocarcinoma (88.9%, 8/9) but low in mucoepidermoid carcinoma (30%, 3/10) and carcinoma ex pleomorphic adenoma (33.3%,3/9). Conclusion：FNAB alone cannot guarantee accurate diagnosis of salivary gland malignancies. Therefore, intraoperativefrozen section biopsy is recommended to make an adequate decision for surgical extent. The clinical experience of pathologistsis also an important factor in improving the accuracy of fine needle aspiration biopsy. (Korean J Otolaryngol 2006;49:922-7)
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