본문 바로가기
KERD
논문KCI 등재

포도구균장독소에 의한 기도상피세포에서의 Rhinovirus 복제 증가

Increase of Rhinovirus Replication in Airway Epithelial Cells byStaphylococcal Enterotoxin A and B

이봉재|권현자|정유삼|장용주|왕종환
대한이비인후과학회 (Korean Society of Otorhinolaryngology-Head and Neck Surgery)|2006.11|대한이비인후과학회지 두경부외과학 (Korean Journal of Otorhinolaryngology-Head and Neck Surgery)|제49권 제11호|pp. 1071-1076

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

리노바이러스·포도구균장독소·황색포도구균·만성 부비동염.Rhinovirus·Staphylococcal enterotoxin·Staphylococcus aureus·Chronic sinusitis.
주제분류이비인후과학

초록

Abstract

Background and Objectives：The toxins generated from Staphylococcus aureus, Staphylococcal enterotoxin A (SEA) and B(SEB), are reported to have an important role in the pathogenesis of chronic rhinosinusitis. As a basic step for elucidating the pathophysiologicresponses of the nasal mucosa of chronic rhinosinusitis associated with rhinovirus infection, this study investigated theeffect of SEA and SEB on rhinovirus infection in A549 cells. Materials and Method：The effect of SEA and SEB on the rhinovirus-induced changes in intercellular adhesion molecule-1 (ICAM-1) expression was assessed by flow cytometry. The effect ofstaphylococcal toxins on the rhinovirus-induced cytokine secretion was measured by ELISA. The effect of the replication of rhinovirusin the cells was examined by viral culture with subsequent determination of viral titer. Results：ICAM-1 expression wasincreased in the rhinovirus infection group. Cytokine secretion was also increased in the rhinovirus infection group. But there wasno additional increase due to staphylococcal toxins regarding the ICAM-1 expression and cytokine secretions. Staphylococcal toxinsincreased viral titer in proportion to toxin concentrations. Conclusion：SEA and SEB increased rhinoviral replication in airwayepithelial cells. This result shows that airway epithelial cells with chronic rhinosinusitis are more favorable environments for rhinovirusinfection. (Korean J Otolaryngol 2006;49:1071-6)

참고문헌 (23)

  1. "Nasal colonization with Staphylococcusaureus is not associated with the severity of symptoms orthe extent of the disease in chronic rhinosinusitis.", 131(3), pp.200~206 (2004)
  2. "Superantigens interact with MHC class II molecules outside of the antigengroove", pp.1115~21
  3. "Colonno RJ. Domains 1and 2 of ICAM-1 are sufficient to bind human rhinovirus. Virus Res1992", pp.173~86
  4. "Viral-induced rhinitis", 12(1), pp.17~20 (1998)
  5. "Mechanismof T-cell stimulation and role in immune response", pp.745~72
  6. "et al. Influence of interleukin-8 challenge in the nasal mucosa in atopicand nonatopic subjects. Am J Respir Crit Care Med 1994", pp.1108~13
  7. "Binary and ternary complexes between T-cell receptor class II MHCand superantigen in vitro", pp.324~7
  8. "Respiratory syncytialvirus increases IL-8 gene expression and protein release in A549 cells.", 269, pp.865~872 (1995)
  9. "Total and specific IgE in nasal polyps is related to local eosinophilicinflammation", 107(4), pp.607~614 (2001)
  10. "A superantigen hypothesis for the pathogenesis of chronic hyperplasticsinusitis with massive nasal polyposis", 17(6), pp.321~326 (2003)
  11. "Bacteriologyof chronic maxillary sinusitis and normal maxillary sinuses: Usingculture and multiplex polymerase chain reaction", 17(3), pp.143~147 (2003)
  12. "Prevalence and role of serum IgE antibodies to the Staphylococcusaureus-derived superantigens SEA and SEB in children withatopic dermatitis", 103, pp.119~124 (1999)
  13. "Bacterial superantigens", 133(3), pp.299~306 (2003)
  14. "IncreasedT-cell receptor Vβ8+T cells in bronchoalveolar lavage fluid of subjectswith poorly controlled asthma A potential role for microbial superantigens", 104(1), pp.37~45 (1999)
  15. "Sinusitis: Bench to bedside. Current findings, future directions", 99, pp.829~848 (1997)
  16. "Evaluation of the staphylococcal exotoxins and their specific IgE inchildhood atopic dermatitis", 104, pp.441~446 (1999)
  17. "Detection of rhinovirusin sinus brushings of patients with acute community-acquiredsinusitis by reverse transcription-PCR.", 35(7), pp.1791~1793 (1997)
  18. "Staphylococcal enterotoxin inducedIL-5 stimulation as a cofactor in the pathogenesis of atopic disease The hygiene hypothesis in reverse?", 58(3), pp.252~256 (2003)
  19. "Effect of clarithromycin on rhinovirus-16infection in A549 cells", 27(1), pp.12~19 (2006)
  20. "Possible influences of staphylococcus aureus on atopic dermatitis-thecolonizing features and the effects of staphylococcal enterotoxins", 29(8), pp.1110~1117 (1999)
  21. "Stimulant-dependent modulation of cytokines and chemokinesby airway epithelial cells Cross talk between pulmonary epithelialand peripheral blood mononuclear cells", 9(1), pp.126~131 (2002)
  22. "Development of rhinovirusstudy model using organ culture of turbinate mucosa", 125(1), pp.41~47 (2005)
  23. "Rhinovirus infection induces mucus hypersecretion", 274, pp.1017~1023 (1998)

관련 논문AI추천

Respiratory Syncytial Virus 감염과 기도 상피세포 염증 반응남동호대한천식알레르기학회 · 천식 및 알레르기2005 · 제25권 제4호기도상피세포에서 Rhinovirus에 의한 점액유전자 발현권현자, 왕종환, 이봉재, 장용주, 정유삼대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2009 · 제52권 제8호폐 상피세포에서 Rhinovirus에 의한 RANTES의 생성 기전김상헌, 김태형, 박성수, 손장원, 신동호, 신성준, 윤호주대한천식알레르기학회 · 천식 및 알레르기2006 · 제26권 제1호Rhinovirus에 의한 감기의 병태생리와 치료장용주대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2003 · 제46권 제2호인체 기관지 상피세포주에서 부신피질스테로이드가 respiratory syncytial 바이러스 감염에의한 RANTES 및 IL-8 mRNA 발현에 미치는 영향김상용, 김현희, 윤소연, 이경일, 이준성대한천식알레르기학회 · 천식 및 알레르기2002 · 제22권 제2호인체 기관지 상피세포에서 Mycoplasma pneumoniae 항원이 IL-8 유전자 발현에 미치는 영향권병철, 김규언, 김우경, 손명현, 이경은, 장광천, 장명웅, 최성연대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2004 · 제14권 제1호

이 간행물의 다른 논문 (10건)

마우스를 모델로 한 동소성 기관이식과 실험적 의의권기환pp. 1050-1056이성대상포진에서 성상신경차단술의 치료 효과에 대한 고찰김용대, 최영호, 정은채, 송시연, 배창훈, 천승민, 이석춘, 백운회pp. 1065-1070급성 비부비동염이 유발된 생쥐에서 항균제의 국소투여 효과안병훈, 남영진, 조유미, 류남희, 박순형, 송인혁, 여창기pp. 1077-1081부비동 및 두개저 병변에서 항법장치를 이용한 비내시경적 진단과 치료: 증례분석 12예임상철, 김각pp. 1082-1086국소 침범한 갑상선 유두상암의 수술적 치료경과김영모, 김재원, 정윤건, 최정석, 윤석영pp. 1087-1090
원문 보기