두경부암에서 p53, Bcl-2, PCNA, VEGF 발현의 임상적 의의: Cisplatin 항암치료의 감수성 및 예후와의 관계
Clinical Significance in Expression of p53, Bcl-2, PCNA and VEGF in head And Neck Squamous Cell Carcinoma: Relationships With Cisplatin Chemosensitivity and Prognosis
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Abstract
：Many researchers have attempted to correlate tumor marker expresion with the response of chemoradiotherapy and prognosis of head and neck cancer. But no clear markers are available that can predict responses to treatment or survival in head and neck cancer. This study investigates the relationship between tumor marker expressions and prognosis. Subjects and Method：Thirty-eight patients who received cisplatin and 5-fluorouracil (5-FU) chemotherapy for the motherapy and the imunohistochemical expression of p53, Bcl-2, VEGF, PCNA. The relationship between survival and tumor marker expression was evaluated in twenty five patients who received chemotherapy and radiotherapy. Results：Expression rates of p53, Bcl-2, VEGF, PCNA were 65%, 26%, 26%, 68%, respectively. Of the markers examined, while the expression of p53 was associated with chemosensitivity (p= 0.02), other markers was not associated with chemosensitivity (p>0.05). The (p= 0.07), tumor markers and other clinical parameters were not associated with recurrence (p>0.05). Five year survival rate was 60%. The primary site of tumor semed to be aso-ciated with the overall survival rate of (p= 0.07). Any other clinical characteristics and tumor markers were not associated with survival. Conclusion：The expression of p53 may be a clinically useful predictor of chemosensitivity in this group of patients. cancer. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :1141-8)
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