외이도 악성 종양의 치료 결과 및 예후 인자 분석
The Analysis of Prognostic Factor and Treatment Outcome of Malignancies of the External Auditory Canal
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background and ObjectivesZZThe purpose of this study was to analyze the survival rate treatment modalities and certain prognostic factors in patients with external auditory canal (EAC)cancer using the University of Pittsburgh TNM Staging System. Subjects and MethodZZMedical records and radiological findings of 33 patients treated for EAC cancer between January 1995 and January 2009 were reviewed retrospectively. The median follow-up period was 65 months (range, 12-182 months). ResultsZZThe most common histological type was squamous cell carcinoma (19 patients;57.6%), followed by adenoid cystic carcinoma (9 patients; 27.3%), basal cell carcinoma (1 patient),adenocarcinoma (1 patient), rhabdomyosarcoma (1 patient), undifferentiated carcinoma (1 patient) and malignant small round cell tumor (1 patient). Seven of 33 patients died of EAC cancer and the overall survival rate was 70.6%. There was a significant difference in the survival rate with respect to TNM stages (p=.031). The 10 yr-survival rate of patients with stage I disease was 100.0%, whereas those of stages II, III and IV were 50.0, 80.0 and 58.3%, respectively. Five of 7 patients with recurrence had a history of initial positive resection margin. ConclusionZZEarly detection and proper surgical treatment with sufficient resection margin are essential for disease-specific survival and prevention of recurrence in patients with EAC cancer. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:275-83
Abstract
Background and ObjectivesZZThe purpose of this study was to analyze the survival rate treatment modalities and certain prognostic factors in patients with external auditory canal (EAC)cancer using the University of Pittsburgh TNM Staging System. Subjects and MethodZZMedical records and radiological findings of 33 patients treated for EAC cancer between January 1995 and January 2009 were reviewed retrospectively. The median follow-up period was 65 months (range, 12-182 months). ResultsZZThe most common histological type was squamous cell carcinoma (19 patients;57.6%), followed by adenoid cystic carcinoma (9 patients; 27.3%), basal cell carcinoma (1 patient),adenocarcinoma (1 patient), rhabdomyosarcoma (1 patient), undifferentiated carcinoma (1 patient) and malignant small round cell tumor (1 patient). Seven of 33 patients died of EAC cancer and the overall survival rate was 70.6%. There was a significant difference in the survival rate with respect to TNM stages (p=.031). The 10 yr-survival rate of patients with stage I disease was 100.0%, whereas those of stages II, III and IV were 50.0, 80.0 and 58.3%, respectively. Five of 7 patients with recurrence had a history of initial positive resection margin. ConclusionZZEarly detection and proper surgical treatment with sufficient resection margin are essential for disease-specific survival and prevention of recurrence in patients with EAC cancer. Korean J Otorhinolaryngol-Head Neck Surg 2010;53:275-83
참고문헌 (25)
- Shih L, "Carcinoma of the external auditory canal: an update", Laryngoscope, 100(11), pp.1215~2118 (1990)
- Dong F, "Adenoid cystic carcinoma of the external auditory canal", Laryngoscope, 118(9), pp.1591~1596 (2008)
- Madsen AR, "Cancer of the external auditory canal and middle ear in Denmark from 1992 to 2001", Head Neck, 30(10), pp.1332~1338 (2008)
- Nyrop M, "Cancer of the external auditory canal", Arch Otolaryngol Head Neck Surg, 128(7), pp.834~837 (2002)
- Kuhel WI, "Cancer of the external auditory canal and temporal bone", Otolaryngol Clin North Am, 29(5), pp.827~852 (1996)
- Arriaga M, "Staging proposal for external auditory meatus carcinoma based on preoperative clinical examination and computed tomography findings", Ann Otol Rhinol Laryngol, 99, pp.714~721 (1990)
- Chang CH, "Treatments and outcomes of malignant tumors of external auditory canal", Am J Otolaryngol, 30(1), pp.44~48 (2009)
- Kim CS, "Partial temporal bone resection for malignancies of the external auditory canal", Korean J Otolaryngol-Head Neck Surg, 41(12), pp.1540~1544 (1998)
- 최재영, "외이도 악성종양의 이하선 침범 및 이하선 림프절 전이 양상", 대한이비인후과학회지 두경부외과학, 47(2), pp.99~102 (2004), 대한이비인후과학회
- Zhang B, "Squamous cell carcinoma of temporal bone: reported on 33 patients", Head Neck, 21(5), pp.461~466 (1999)
- Moody SA, "Squamous cell carcinoma of the external auditory canal: an evaluation of a staging system", Am J Otol, 21(4), pp.582~588 (2000)
- Moore MG, "Management outcomes following lateral temporal bone resection for ear and temporal bone malignancies", Otolaryngol Head Neck Surg, 137(6), pp.893~898 (2007)
- Austin JR, "Squamous cell carcinoma of the external auditory canal. Therapeutic prognosis based on a proposed stag ing system", Arch Otolaryngol Head Neck Surg, 120(11), pp.1228~1232 (1994)
- Lobo D, "Squamous cell carcinoma of the external auditory canal", Skull Base, 18(3), pp.167~172 (2008)
- Ito M, "Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement?", Acta Otolaryngol, 1(7) (2009)
- Yin M, "Analysis of 95 cases of squamous cell carcinoma of the external and middle ear", Auris Nasus Larynx, 33(3), pp.251~257 (2006)
- Pfreundner L, "Carcinoma of the external auditory canal and middle ear", Int J Radiat Oncol Biol Phys, 44(4), pp.777~788 (1999)
- Nakagawa T, "Squamous cell carcinoma of the external auditory canal and middle ear: an operation combined with preoperative chemoradiotherapy and a free surgical margin", Otol Neurotol, 27(2), pp.242~249 (2006)
- Ogawa K, "Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients", Int J Radiat Oncol Biol Phys, 68(5), pp.1326~1334 (2007)
- Lim LH, "Malignancy of the temporal bone and external auditory canal", Otolaryngol Head Neck Surg, 122(6), pp.882~886 (2000)
- Birzgalis AR, "Small M. Severe radionecrosis of the temporal bone", J Laryngol Otol, 107(103), pp.183~187 (1993)
- Hashi N, "The role of radiotherapy in treating squamous cell carcinoma of the external auditory canal, especially in early stages of disease", Radiother Oncol, 56(2), pp.221~225 (2000)
- Pemberton LS, "Primary radical radiotherapy for squamous cell carcinoma of the middle ear and external auditory cana--an historical series", Clin Oncol (R Coll Radiol), 18(5), pp.390~394 (2006)
- Hashi N, "The role of radiotherapy in treating squamous cell carcionma of the external auditory canal, especially in the eary stages of disease", Radiother Oncol, 56, pp.221~225 (2000)
- Pulec JL, "Adenoid cystic carcinoma (Cylindroma) of the external auditory canal", Trans Am Acad Ophthalmol Oto laryngol, 67, pp.673~694 (1963)