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Congenital Intratympanic Membrane Cholesteatoma:Report of Three Cases and Review of the Literature

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Congenital intratympanic membrane cholesteatomas (ITMCs) are very rare. We present 3 cases of congenital ITMCs. In the first case, there was a small keratin pearl in the center of the tympanic membrane. In the other cases, cholesteatomas were found in the periphery. In all cases, cholesteatomas were confined to the space between the outer epithelial layer and the middle fibrous layer. The pathogenesis of this rare disease and the natural history are not well known. In some reported cases, it grows and invades into the middle ear. However, in the present study, the lateral growing of the ITMC was observed in one of the three cases. Furthermore, it naturally grew outward and finally moved to the external auditory canal. Careful periodic observation should be considered for alternative treatments. We present three different cases of ITMC with a review of the literature.

Abstract

Congenital intratympanic membrane cholesteatomas (ITMCs) are very rare. We present 3 cases of congenital ITMCs. In the first case, there was a small keratin pearl in the center of the tympanic membrane. In the other cases, cholesteatomas were found in the periphery. In all cases, cholesteatomas were confined to the space between the outer epithelial layer and the middle fibrous layer. The pathogenesis of this rare disease and the natural history are not well known. In some reported cases, it grows and invades into the middle ear. However, in the present study, the lateral growing of the ITMC was observed in one of the three cases. Furthermore, it naturally grew outward and finally moved to the external auditory canal. Careful periodic observation should be considered for alternative treatments. We present three different cases of ITMC with a review of the literature.

참고문헌 (11)

  1. Nejadkazem M, "Intratympanic membrane cholesteatoma after tympanoplasty with the underlay technique", Arch Otolaryngol Head Neck Surg, 134(5), pp.501~502 (2008)
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  6. Yoshida T, "Intratympanic membrane congenital cholesteatoma", Int J Pediatr Otorhinolaryngol, 73(7), pp.1003~1005 (2009)
  7. Lee BD, "Congenital cholesteatoma of the tympanic membrane", Ear Nose Throat J, 90(12), pp.E36~E37 (2011)
  8. Friedberg J, "Congenital cholesteatoma", Laryngoscope, 104(3 Pt 2), pp.1~24 (1994)
  9. Aimi K, "Role of the tympanic ring in the pathogenesis of congenital cholesteatoma", Laryngoscope, 93(9), pp.1140~1146 (1983)
  10. Chole RA, "Basal lamina breaks in the histogenesis of cholesteatoma", Laryngoscope, 95(3), pp.270~275 (1985)
  11. Suzuki T, "Congenital cholesteatoma in the tympanic membrane", Int J Pediatr Otorhinolaryngol Extra, 2(1), pp.48~50 (2007)

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