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외이도의 종물 형태로 나타난 급성 전골수성 백혈병의 골수 외 재발 1예

A Case of Extramedullary Relapsed Acute Promyelocytic Leukemia Presenting as a Mass in the External Auditory Canal

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주제분류이비인후과학

초록

Acute promyelocytic leukemia (APL) is a unique subtype of acute myelogenous leukemia for which complete remission is induced by using anticancer drugs with all-trans retinoic acid (ATRA). Extramedullary involvement at relapse is occasionally observed in patients with APL, and is said to be more common after treatment with ATRA. We describe a 35-year-old man who had a relapse due to a mass that developed in the external auditory canal after treatment with ATRA. He was successfully treated with arsenic trioxide and radiotherapy. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(9):688-91

Abstract

Acute promyelocytic leukemia (APL) is a unique subtype of acute myelogenous leukemia for which complete remission is induced by using anticancer drugs with all-trans retinoic acid (ATRA). Extramedullary involvement at relapse is occasionally observed in patients with APL, and is said to be more common after treatment with ATRA. We describe a 35-year-old man who had a relapse due to a mass that developed in the external auditory canal after treatment with ATRA. He was successfully treated with arsenic trioxide and radiotherapy. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(9):688-91

참고문헌 (12)

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  6. Lafayette TC, "External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature", J Pediatr Hematol Oncol, 32(3), pp.229~232 (2010)
  7. Kelaidi C, "Late first relapses in APL treated with all-trans-retinoic acid- and anthracycline- based chemotherapy: the European APL group experience (APL 91 and APL 93 trials)", Leukemia, 20(5), pp.905~907 (2006)
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  11. Seftel M, "Acute promyelocytic leukemia presenting as a mass in the external ear", Blood, 121(23), pp.4616~ (2013)
  12. Au WY, "Unusual sites of involvement by hematologic malignancies. Case 3. External auditory canal tumor: a rare chloroma in acute promyelocytic leukemia with a complete response to arsenic trioxide", J Clin Oncol, 19(19), pp.3993~3995 (2001)

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