빅데이터를 이용한 소아 중이염과 천식의 연관성 분석
Is Pediatric Otitis Media Correlated with an Increased Risk of Bronchial Asthma?: An 11-Year Nationwide Population-Based Study
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Objectives Pediatric otitis media is closely related to upper respiratory illness and is one of the most common causes of hospital visiting and antibiotic prescription. Although there are many studies of asthma with other upper respiratory tract infections, few studies have investigated the relationship between asthma and otitis media. This study estimated whether pediatric otitis media is associated with the risk of asthma using the Korean National Health Insurance Service National Sample Cohort (NHIS-NSC 2002-2013) data. Subjects and Method In using the NHIS-NSC 2002-2013 data, children diagnosed as otitis media or bronchial asthma in 2002 were excluded from children from 1 to 8 years old in 2003. The patients who were diagnosed and treated as otitis media (n=8506) and the comparison group (n=65886) were enrolled in 2003. During a 10-year follow-up period until December 2013, the incidence of asthma between two groups was analyzed and the result was adjusted for the impact of comorbidities such as atopic dermatitis, allergic rhinitis with multivariate linear regression analyses. Results In 2003, 20.88% of first-year-old children were treated with otitis media. The prevalence of otitis media was maintained at 15% until age 4 and decreased rapidly after 5 years of age. Asthma incidence was reported higher in patients with otitis media compared to the comparison group, with an adjusted odds ratio of 1.196 [95% confidence interval (CI) 1.127-1.269] followed by patients with atopic dermatitis [hazard ratio (HR) 1.261, 95% CI 1.196-1.33], allergic rhinitis (HR 1.473, 95% CI 1.409-1.54). Conclusion Pediatric otitis media appeared to be associated with an increased risk of developing bronchial asthma after adjusting for other risk factors. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(10):497-503
Abstract
Background and Objectives Pediatric otitis media is closely related to upper respiratory illness and is one of the most common causes of hospital visiting and antibiotic prescription. Although there are many studies of asthma with other upper respiratory tract infections, few studies have investigated the relationship between asthma and otitis media. This study estimated whether pediatric otitis media is associated with the risk of asthma using the Korean National Health Insurance Service National Sample Cohort (NHIS-NSC 2002-2013) data. Subjects and Method In using the NHIS-NSC 2002-2013 data, children diagnosed as otitis media or bronchial asthma in 2002 were excluded from children from 1 to 8 years old in 2003. The patients who were diagnosed and treated as otitis media (n=8506) and the comparison group (n=65886) were enrolled in 2003. During a 10-year follow-up period until December 2013, the incidence of asthma between two groups was analyzed and the result was adjusted for the impact of comorbidities such as atopic dermatitis, allergic rhinitis with multivariate linear regression analyses. Results In 2003, 20.88% of first-year-old children were treated with otitis media. The prevalence of otitis media was maintained at 15% until age 4 and decreased rapidly after 5 years of age. Asthma incidence was reported higher in patients with otitis media compared to the comparison group, with an adjusted odds ratio of 1.196 [95% confidence interval (CI) 1.127-1.269] followed by patients with atopic dermatitis [hazard ratio (HR) 1.261, 95% CI 1.196-1.33], allergic rhinitis (HR 1.473, 95% CI 1.409-1.54). Conclusion Pediatric otitis media appeared to be associated with an increased risk of developing bronchial asthma after adjusting for other risk factors. Korean J Otorhinolaryngol-Head Neck Surg 2017;60(10):497-503
참고문헌 (21)
- MacIntyre EA, "Otitis media in infancy and the development of asthma and atopic disease", Curr Allergy Asthma Rep, 12(6), pp.547~550 (2012)
- Holt PG, "Virus infection and allergy in the development of asthma: what is the connection?", Curr Opin Allergy Clin Immunol, 12(2), pp.151~157 (2012)
- Sevin CM, "Infections and asthma: new insights into old ideas", Clin Exp Allergy, 40(8), pp.1142~1154 (2010)
- Walton RP, "Role of respiratory viral infections in the development of atopic conditions", Curr Opin Allergy Clin Immunol, 8(2), pp.150~153 (2008)
- Rosenfeld RM, "Clinical Practice Guideline: otitis media with effusion executive summary (update)", Otolaryngol Head Neck Surg, 154(2), pp.201~214 (2016)
- Stenström C, "General illness and need of medical care in otitis prone children", Int J Pediatr Otorhinolaryngol, 29(1), pp.23~32 (1994)
- Heinrich J, "Air pollution and otitis media: a review of evidence from epidemiologic studies", Curr Allergy Asthma Rep, 4(4), pp.302~309 (2004)
- Nystad W, "Recurrent respiratory tract infections during the first 3 years of life and atopy at school age", Allergy, 53(12), pp.1189~1194 (1998)
- Njå F, "Airway infections in infancy and the presence of allergy and asthma in school age children", Arch Dis Child, 88(7), pp.566~569 (2003)
- Stein RT, "Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years", Lancet, 354(9178), pp.541~545 (1999)
- Kusel MM, "Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study", Pediatr Infect Dis J, 25(8), pp.680~686 (2006)
- Lemanske RF Jr, "Rhinovirus illnesses during infancy predict subsequent childhood wheezing", J Allergy Clin Immunol, 116(3), pp.571~577 (2005)
- Murk W, "Prenatal or early-life exposure to antibiotics and risk of childhood asthma: a systematic review", Pediatrics, 127(6), pp.1125~1138 (2011)
- Eldeirawi K, "Frequent ear infections in infancy and the risk of asthma in Mexican American children", J Asthma, 47(4), pp.473~477 (2010)
- Alles R, "The prevalence of atopic disorders in children with chronic otitis media with effusion", Pediatr Allergy Immunol, 12(2), pp.102~106 (2001)
- Hurst DS, "The role of allergy in otitis media with effusion", Otolaryngol Clin North Am, 44(3), pp.637~654 (2011)
- Martines F, "Otitis media with effusion with or without atopy: audiological findings on primary schoolchildren", Am J Otolaryngol, 32(6), pp.601~606 (2011)
- Juhn YJ, "What does tympanostomy tube placement in children teach us about the association between atopic conditions and otitis media?", Curr Allergy Asthma Rep, 14(7), pp.447~ (2014)
- Oh JH, "Interaction between allergy and middle ear infection", Curr Allergy Asthma Rep, 16(9), pp.66~ (2016)
- Yeo SG, "The role of allergic rhinitis in the development of otitis media with effusion: effect on eustachian tube function", Am J Otolaryngol, 28(3), pp.148~152 (2007)
- Kanazawa H, "New insights into eosinophilic otitis media", Curr Allergy Asthma Rep, 15(12), pp.76~ (2015)