삼출성 중이염으로 환기관삽입술을 받은 소아에서 중이삼출액 내의 면역세포 유형과 환기관 이루 발생의 관계
The Relation between Tympanostomy Tube Otorrhea and Types of Immune Cells in Middle Ear Effusion in Children with Otitis Media with Effusion
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Background and Objectives Tympanostomy tube insertion is one of the most commonsurgical procedures in children. Despite aseptic procedures with prophylactic antibiotic treatment,postoperative otorrhea may be encountered in some patients. The purpose of this study isto identify the relation between the types of immune cells in otitis media with effusion (OME)and tympanostomy tube otorrhea (TTO) in children. Subjects and Method Fifty-six patients underwent tympanostomy tube insertion withOME were analyzed retrospectively. Fluid from OME was harvested by suction via syringe connectorafter myringotomy. Light microscopic examination of middle ear effusion was performedby a pathologist after hematoxylin and eosin staining. We analyzed the relation between the typesof immune cells from middle ear effusion and TTO. Results Of 56 children, 36 were male and 22 were female. The mean age for tympanostomytube insertion was 3.56 (±2.63) years, with the average follow-up period of 12.56 (±9.96)months. Neutrophils were detected in 19, eosinophils in 14, lymphocytes in 22, mast cells in 2,plasma cells in 7, and histiocytes in 9. TTO occurred in 15 patients. In patients with early TTO,eosinophils were detected more frequently than in patients without TTO (p=0.006). Plasmacells were detected more frequently in patient with late TTO than without TTO (p=0.011). Conclusion According to the analysis of different types of immune cells, eosinophils in themiddle ear effusion related with the occurrence of TTO.
Abstract
Background and Objectives Tympanostomy tube insertion is one of the most commonsurgical procedures in children. Despite aseptic procedures with prophylactic antibiotic treatment,postoperative otorrhea may be encountered in some patients. The purpose of this study isto identify the relation between the types of immune cells in otitis media with effusion (OME)and tympanostomy tube otorrhea (TTO) in children. Subjects and Method Fifty-six patients underwent tympanostomy tube insertion withOME were analyzed retrospectively. Fluid from OME was harvested by suction via syringe connectorafter myringotomy. Light microscopic examination of middle ear effusion was performedby a pathologist after hematoxylin and eosin staining. We analyzed the relation between the typesof immune cells from middle ear effusion and TTO. Results Of 56 children, 36 were male and 22 were female. The mean age for tympanostomytube insertion was 3.56 (±2.63) years, with the average follow-up period of 12.56 (±9.96)months. Neutrophils were detected in 19, eosinophils in 14, lymphocytes in 22, mast cells in 2,plasma cells in 7, and histiocytes in 9. TTO occurred in 15 patients. In patients with early TTO,eosinophils were detected more frequently than in patients without TTO (p=0.006). Plasmacells were detected more frequently in patient with late TTO than without TTO (p=0.011). Conclusion According to the analysis of different types of immune cells, eosinophils in themiddle ear effusion related with the occurrence of TTO.
참고문헌 (14)
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