Sentinel Lymph Node Centered Selective Neck Dissection Does Not Have Benefits Over Supraomohyoid Neck Dissection in Patients with cT1T2N0 Tongue Cancer
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Background and Objectives This study aimed to evaluate the clinical efficacy of sentinelnode centered selective neck dissection in patients with early stage tongue cancer (T1T2N0). Subjects and Method Lymphoscintigraphy was performed for 12 patients, subsequentlyfollowed by sentinel node centered selective neck dissection. The location of the sentinel node,pathological confirmation of node metastasis, and follow-up recurrence were analyzed. Results In total, 19 sentinel lymph nodes were identified. Of these, 18 were located in levelsI to III, and one in level IV. After surgery, 3 patients (25%) were diagnosed with neck nodemetastasis: two experienced sentinel node metastasis and one experienced skipped metastasis. During follow-up, 3 of the 12 patients (25%) experienced recurrence. Conclusion The recurrence of lymph node could be covered with supraomohyoid neck dissection,which indicates that it has superiority over sentinel node centered selective neck dissectionin preventing recurrence in T1T2N0 tongue cancer patients.
Abstract
Background and Objectives This study aimed to evaluate the clinical efficacy of sentinelnode centered selective neck dissection in patients with early stage tongue cancer (T1T2N0). Subjects and Method Lymphoscintigraphy was performed for 12 patients, subsequentlyfollowed by sentinel node centered selective neck dissection. The location of the sentinel node,pathological confirmation of node metastasis, and follow-up recurrence were analyzed. Results In total, 19 sentinel lymph nodes were identified. Of these, 18 were located in levelsI to III, and one in level IV. After surgery, 3 patients (25%) were diagnosed with neck nodemetastasis: two experienced sentinel node metastasis and one experienced skipped metastasis. During follow-up, 3 of the 12 patients (25%) experienced recurrence. Conclusion The recurrence of lymph node could be covered with supraomohyoid neck dissection,which indicates that it has superiority over sentinel node centered selective neck dissectionin preventing recurrence in T1T2N0 tongue cancer patients.
참고문헌 (20)
- Ganly I, "Early stage squamous cell cancer of the oral tongue--clinicopathologic features affecting outcome", Cancer, 118(1), pp.101~111 (2012)[DOI]
- Shim SJ, "Clinical outcomes for T 1-2 N 0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy", Radiat Oncol, 5, pp.43~ (2010)[DOI]
- del Papa MF, "Isolation and characterization of alfalfa-nodulating rhizobia present in acidic soils of central argentina and uruguay", Appl Environ Microbiol, 65(4), pp.1420~1427 (1999)
- Ho CM, "Occult lymph node metastasis in small oral tongue cancers", Head Neck, 14(5), pp.359~363 (1992)[DOI]
- Xie N, "Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early-stage tongue squamous cell carcinoma", J Oral Pathol Med, 44(4), pp.266~272 (2015)[DOI]
- D'Cruz AK, "Elective versus therapeutic neck dissection in node-negative oral cancer", N Engl J Med, 373(6), pp.521~529 (2015)[DOI]
- Ren ZH, "Elective versus therapeutic neck dissection in node-negative oral cancer: evidence from five randomized controlled trials", Oral Oncol, 51(11), pp.976~981 (2015)[DOI]
- Haddadin KJ, "Improved survival for patients with clinically T1", T2, N0 tongue tumors undergoing a prophylactic neck dissection, 1999, pp.21(6), 517~525
- Chepeha DB, "Functional assessment using Constant's Shoulder Scale after modified radical and selective neck dissection", Head Neck, 24(5), pp.432~436 (2002)[DOI]
- Rogers SN, "Quality of life following neck dissections", Acta Otolaryngol, 124(3), pp.231~236 (2004)[DOI]
- Lea J, "Metastases to level IIb in squamous cell carcinoma of the oral cavity: a systematic review and meta-analysis", Head Neck, 32(2), pp.184~190 (2010)
- Shah JP, "The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity", Cancer, 66(1), pp.109~113 (1990)[DOI]
- Dias FL, "Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth", Otolaryngol Head Neck Surg, 134(3), pp.460~465 (2006)[DOI]
- Stoeckli SJ, "Sentinel node biopsy for early oral and oropharyngeal squamous cell carcinoma", Eur Arch Otorhinolaryngol, 266(6), pp.787~793 (2009)[DOI]
- Stoeckli SJ, "Sentinel node biopsy for oral and oropharyngeal squamous cell carcinoma of the head and neck", Laryngoscope, 117(9), pp.1539~1551 (2007)[DOI]
- Rodrigo JP, "Management of the clinically negative neck in early-stage head and neck cancers after transoral resection", Head Neck, 33(8), pp.1210~1219 (2011)[DOI]
- Civantos FJ, "Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial", J Clin Oncol, 28(8), pp.1395~1400 (2010)[DOI]
- Tsushima N, "The role of prophylactic neck dissection and tumor thickness evaluation for patients with cN0 tongue squamous cell carcinoma", Eur Arch Otorhinolaryngol, 273(11), pp.3987~3992 (2016)[DOI]
- Brennan PA, "An update on the latest evidence for managing the clinically negative neck (cN0) in oral squamous cell carcinoma", Oral Dis, 23(3), pp.287~291 (2017)[DOI]
- Brazilian Head, "Results of a prospective trial on elective modified radical classical versus supraomohyoid neck dissection in the management of oral squamous carcinoma", Am J Surg, 176(5), pp.422~427 (1998)[DOI]