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악성 경부임파선병증으로 오인된 연판화증 1예

Malakoplakia of Head and Neck Mimicking Malignant Lymphadenopathy: A Case Report

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참고문헌

주제분류이비인후과학

초록

Malakoplakia is usually found in the genitourinary tract; however, it occurs uncommonly as a chronic inflammatory disease and rarely in the head and neck area, having been reported in the literature only few times. Here, we report, with a review of the related literature, a case of malakoplakia on the posterior neck. A 76-year-old male patient visited our institution presenting a rapidly growing neck mass that had invaded the overlying skin for several weeks. The results of imaging studies strongly indicated a malignant tumor, but an accurate diagnosis was not made until after a fine needle aspiration biopsy was undertaken twice. The lesion was completely excised with an extended radical neck dissection including the overlying skin and scalene muscle upon consent of the patient. The pathological diagnosis was made with various immunohistochemical staining methods including Von Kossa, Periodic acid-Schiff-diastase, CD-68 and CD163. During the 24 months follow-up after the surgery, there was no sign of recurrence.

Abstract

Malakoplakia is usually found in the genitourinary tract; however, it occurs uncommonly as a chronic inflammatory disease and rarely in the head and neck area, having been reported in the literature only few times. Here, we report, with a review of the related literature, a case of malakoplakia on the posterior neck. A 76-year-old male patient visited our institution presenting a rapidly growing neck mass that had invaded the overlying skin for several weeks. The results of imaging studies strongly indicated a malignant tumor, but an accurate diagnosis was not made until after a fine needle aspiration biopsy was undertaken twice. The lesion was completely excised with an extended radical neck dissection including the overlying skin and scalene muscle upon consent of the patient. The pathological diagnosis was made with various immunohistochemical staining methods including Von Kossa, Periodic acid-Schiff-diastase, CD-68 and CD163. During the 24 months follow-up after the surgery, there was no sign of recurrence.

참고문헌 (8)

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  5. Coates M, "A case of cutaneous malakoplakia in the head and neck region and review of the literature", Head Neck Pathol, 10(4), pp.444~450 (2016)
  6. Stanton MJ, "Malacoplakia : a study of the literature and current concepts of pathogenesis, diagnosis and treatment", J Urol, 125(2), pp.139~146 (1981)
  7. Oliver JM, "Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome", Am J Pathol, 85(2), pp.395~418 (1976)
  8. Abdou NI, "Malakoplakia : evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo", N Engl J Med, 297(26), pp.1413~1419 (1977)

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