알레르기 진단을 위한 원인 항원 패널 선정 최적화 연구
Optimization of Allergen Panels for Diagnosis of Allergic Rhinitis
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The selection of allergen panel is very important to test for innumerable allergens throughoutthe Korea. However, the allergens studied are heterogeneous depending on the area the patientlive and there is no methodological unification. Although, testing panel of allergens should betailored according to the geographical areas, considering the relatively small Korean Peninsula,common inhalant allergens for test could be retrieved from the published data. Hence, this studyis aimed to review the longitudinal variance of allergens in patients with allergic rhinitis livein several regional provinces of Korea, figure out the similarity and differences of sensitized allergensresults derived from each study and finally make a guideline for physician in selectingthe offending allergens to test. From the inception, studies which analyzing the offending allergensby either ImmunoCAP®, Multiple Allergen Simultaneous Test or Skin testing were reviewedand we found that the common sensitized allergens are house dust mites, pollen andmold plus 1-2 notable different allergens according to the specific regions. Especially, a total of10±3 allergens adequately detected most of the sensitization of the major regions of Korea accordingto each age groups and special regional features. This study suggest that physicians shouldperform the screening of allergic rhinitis with minimally selected allergen in the light of age categoriesand special regional features. Standardization of allergens selection process would bepredicted to have enormous benefits in establishing an insurance policy, giving sound scientificevidence and monitoring the antigenic variations of the Korean Peninsula.
Abstract
The selection of allergen panel is very important to test for innumerable allergens throughoutthe Korea. However, the allergens studied are heterogeneous depending on the area the patientlive and there is no methodological unification. Although, testing panel of allergens should betailored according to the geographical areas, considering the relatively small Korean Peninsula,common inhalant allergens for test could be retrieved from the published data. Hence, this studyis aimed to review the longitudinal variance of allergens in patients with allergic rhinitis livein several regional provinces of Korea, figure out the similarity and differences of sensitized allergensresults derived from each study and finally make a guideline for physician in selectingthe offending allergens to test. From the inception, studies which analyzing the offending allergensby either ImmunoCAP®, Multiple Allergen Simultaneous Test or Skin testing were reviewedand we found that the common sensitized allergens are house dust mites, pollen andmold plus 1-2 notable different allergens according to the specific regions. Especially, a total of10±3 allergens adequately detected most of the sensitization of the major regions of Korea accordingto each age groups and special regional features. This study suggest that physicians shouldperform the screening of allergic rhinitis with minimally selected allergen in the light of age categoriesand special regional features. Standardization of allergens selection process would bepredicted to have enormous benefits in establishing an insurance policy, giving sound scientificevidence and monitoring the antigenic variations of the Korean Peninsula.
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