인공장기를 이용한 구강·인두·식도의 재건: 연구의 경험과 한계
Development of Artificial Substitutes for Upper Digestive Tract: Personal Experience of Trials and Errors
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The current treatments for esophageal diseases, such as carcinomas, trauma or congenitalmalformations, require surgical intervention, and esophageal reconstruction using redundantparts of the gastrointestinal tract. However, the use of gastrointestinal segments can cause varioussurgical morbidities and mortality because additional abdominal surgery may be requiredat the expense of other anatomic structures. Therefore, tissue engineering using various biomaterialor cell sources has emerged as an alternative strategy of biomimicking the nativeesophageal tissue that could be implanted as an artificial graft. Although tissue engineeringtechniques have promise as an effective regenerative strategy, no functional solution currentlyexists for esophageal reconstruction. Here, we present a review of the progress made in the fieldof regenerative medicine for esophageal reconstruction based on the personal experience.
Abstract
The current treatments for esophageal diseases, such as carcinomas, trauma or congenitalmalformations, require surgical intervention, and esophageal reconstruction using redundantparts of the gastrointestinal tract. However, the use of gastrointestinal segments can cause varioussurgical morbidities and mortality because additional abdominal surgery may be requiredat the expense of other anatomic structures. Therefore, tissue engineering using various biomaterialor cell sources has emerged as an alternative strategy of biomimicking the nativeesophageal tissue that could be implanted as an artificial graft. Although tissue engineeringtechniques have promise as an effective regenerative strategy, no functional solution currentlyexists for esophageal reconstruction. Here, we present a review of the progress made in the fieldof regenerative medicine for esophageal reconstruction based on the personal experience.
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