쇼그렌 증후군 진단에서 이하선 전산화단층촬영의 유용성
Diagnostic Role of Parotid Computed Tomography for Identifying Sjögren’s Syndrome
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Background and Objectives Sjögren’s syndrome (SS) is an autoimmune inflammatory disorderof exocrine glands characterized by dry mouth and eye. Recently, ultrasonography hasbecome a valuable tool for the assessment of salivary gland involvement in SS although studieson the usefulness of salivary gland CT is rare. In this regard, we evaluated the diagnostic accuracyof parotid gland CT for SS. Subjects and Method A total of 91 patients with sicca symptoms took a parotid CT, a serologytest, an ophthalmologic examination and a minor salivary gland biopsy. At the end, as a standard,we diagnosed the primary SS according to the new 2016 American College of Rheumatology/European League Against Rheumatism classification criteria. The diagnostic value ofparotid CT was compared by the McNemar test. Results Of the total of 91 patients with parotid CT, 37 (40.7%) patients met the SS classificationcriteria. On the parotid CT, heterogeneity of the parotid gland has the sensitivity of 74.1%,specificity of 70.3%, and accuracy of 71.4%. The abnormal fat tissue deposition showed the sensitivityof 74.1%, specificity of 81.3%, and accuracy of 79.1%. Diffuse calcification was seen in1/91 SS patients (sensitivity 3.7%, specificity 100%, accuracy 71.4%). Conclusion Parotid CT is helpful for the diagnosis of SS. The presence of heterogeneity and fattissue deposition are highly sensitive for the accuracy of SS. Diffuse calcification in bilateral parotidglands is highly specific for SS.
Abstract
Background and Objectives Sjögren’s syndrome (SS) is an autoimmune inflammatory disorderof exocrine glands characterized by dry mouth and eye. Recently, ultrasonography hasbecome a valuable tool for the assessment of salivary gland involvement in SS although studieson the usefulness of salivary gland CT is rare. In this regard, we evaluated the diagnostic accuracyof parotid gland CT for SS. Subjects and Method A total of 91 patients with sicca symptoms took a parotid CT, a serologytest, an ophthalmologic examination and a minor salivary gland biopsy. At the end, as a standard,we diagnosed the primary SS according to the new 2016 American College of Rheumatology/European League Against Rheumatism classification criteria. The diagnostic value ofparotid CT was compared by the McNemar test. Results Of the total of 91 patients with parotid CT, 37 (40.7%) patients met the SS classificationcriteria. On the parotid CT, heterogeneity of the parotid gland has the sensitivity of 74.1%,specificity of 70.3%, and accuracy of 71.4%. The abnormal fat tissue deposition showed the sensitivityof 74.1%, specificity of 81.3%, and accuracy of 79.1%. Diffuse calcification was seen in1/91 SS patients (sensitivity 3.7%, specificity 100%, accuracy 71.4%). Conclusion Parotid CT is helpful for the diagnosis of SS. The presence of heterogeneity and fattissue deposition are highly sensitive for the accuracy of SS. Diffuse calcification in bilateral parotidglands is highly specific for SS.
참고문헌 (17)
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