편도주위농양 치료 시 부가적 스테로이드의 효과
The Effects of Adjunctive Steroids in the Treatment of Peritonsillar Abscess
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Background and Objectives Steroids have strong anti-inflammatory, anti-edema, and antipyreticeffects. Since there are few studies on the use of steroids in the treatment of peritonsillarabscess in Korea, we aimed at this study to investigate the effects of steroids along withantibiotics in the treatment of peritonsillar abscess. Subjects and Method A retrospective study was conducted on 75 patients who were admittedfrom 2014 to 2019. Between 2014 and 2017, only antibiotics were administrated after incisionaldrainage (no-use group), but between 2018 and 2019, antibiotics and adjunctive steroidswere administrated after incisional drainage (steroids group). Symptoms of patients, bloodtests, diets available, and hospitalization period were compared between the two groups. Results The length of hospital stay for the steroids group (n=24) and the no-use group (n=51)was 4.2±1.3 days and of 5.1±1.8 days (p=0.046), respectively, showing significantly shortenedtime for the steroids group. The rate of change in 48-hour C-reactive protein was 53.3% and20% for the steroid group and no-use group (p=0.013), respectively. However, there was no differencesbetween the two groups in the rate of change in body temperature at 12 hours of treatment,the diet available at 12 hours, and rate of change in the number of white blood cells after48 hours of treatment. Conclusion Adjunctive steroids for peritonsillar abscess can be a useful treatment that showsrapid improvement of symptoms and C-reactive protein, and shorter hospitalization periods.
Abstract
Background and Objectives Steroids have strong anti-inflammatory, anti-edema, and antipyreticeffects. Since there are few studies on the use of steroids in the treatment of peritonsillarabscess in Korea, we aimed at this study to investigate the effects of steroids along withantibiotics in the treatment of peritonsillar abscess. Subjects and Method A retrospective study was conducted on 75 patients who were admittedfrom 2014 to 2019. Between 2014 and 2017, only antibiotics were administrated after incisionaldrainage (no-use group), but between 2018 and 2019, antibiotics and adjunctive steroidswere administrated after incisional drainage (steroids group). Symptoms of patients, bloodtests, diets available, and hospitalization period were compared between the two groups. Results The length of hospital stay for the steroids group (n=24) and the no-use group (n=51)was 4.2±1.3 days and of 5.1±1.8 days (p=0.046), respectively, showing significantly shortenedtime for the steroids group. The rate of change in 48-hour C-reactive protein was 53.3% and20% for the steroid group and no-use group (p=0.013), respectively. However, there was no differencesbetween the two groups in the rate of change in body temperature at 12 hours of treatment,the diet available at 12 hours, and rate of change in the number of white blood cells after48 hours of treatment. Conclusion Adjunctive steroids for peritonsillar abscess can be a useful treatment that showsrapid improvement of symptoms and C-reactive protein, and shorter hospitalization periods.
참고문헌 (18)
- Steyer TE, "Peritonsillar abscess : Diagnosis and treatment", Am Fam Physician, 65(1), pp.93~96 (2002)
- Khayr W, "Management of peritonsillar abscess : Needle aspiration versus incision and drainage versus tonsillectomy", Am J Ther, 12(4), pp.344~350 (2005)
- Battaglia A, "Comparison of medical therapy alone to medical therapy with surgical treatment of peritonsillar abscess", Otolaryngol Head Neck Surg, 158(2), pp.280~286 (2018)
- Herzon FS, "Medical and surgical treatment of peritonsillar, retropharyngeal, and parapharyngeal abscesses", Curr Infect Dis Rep, 8(3), pp.196~202 (2006)
- Ozbek C, "Use of steroids in the treatment of peritonsillar abscess", J Laryngol Otol, 118(6), pp.439~442 (2004)
- Chau JK, "Corticosteroids in peritonsillar abscess treatment : A blinded placebocontrolled clinical trial", Laryngoscope, 124(1), pp.97~103 (2014)
- 이연지, "The Efficacy of Corticosteroids in the Treatment of Peritonsillar Abscess: A Meta-Analysis", Clinical and Experimental Otorhinolaryngology, 9(2), pp.89~97 (2016), 대한이비인후과학회[DOI]
- Hur K, "Adjunct steroids in the treatment of peritonsillar abscess : A systematic review", Laryngoscope, 128(1), pp.72~77 (2018)
- Powell J, "An evidence-based review of peritonsillar abscess", Clin Otolaryngol, 37(2), pp.136~145 (2012)
- Koçak HE, "Is corticosteroid a treatment choice for the management of peritonsillar abscess", Auris Nasus Larynx, 45(2), pp.291~294 (2018)
- Abdallah C, "Acute epiglottitis: Trends, diagnosis and management", Saudi J Anaesth, 6(3), pp.279~281 (2012)
- 김명우, "한국에서의 급성 안면마비 환자에 대한 조기 스테로이드치료의 의미와 중요성", 대한이비인후-두경부외과학회지, 59(5), pp.346~352 (2016), 대한이비인후과학회[DOI]
- 박현호, "돌발성 난청 환자에서 고용량 스테로이드 요법과 초고용량 스테로이드 요법의 치료 효과 비교", 대한이비인후-두경부외과학회지, 52(7), pp.566~571 (2009), 대한이비인후과학회
- 송커다모, "조영제 사용 후의 영상만을 이용한 편도주위농양 진단과 치료", 대한이비인후-두경부외과학회지, 61(2), pp.99~102 (2018), 대한이비인후과학회[DOI]
- Sproston NR, "Role of C-reactive protein at sites of inflammation and infection", Front Immunol, 9, pp.754~ (2018)
- Hayward G, "Corticosteroids for pain relief in sore throat: Systematic review and meta-analysis", BMJ, 339, pp.b2976~ (2009)
- Crockard AD, "Methylprednisolone-induced neutrophil leukocytosis--downmodulation of neutrophil L-selectin and Mac-1 expression and induction of granulocyte-colony stimulating factor", Int J Clin Lab Res, 28(2), pp.110~115 (1998)
- Hardman JC, "Do corticosteroids improve outcomes in peritonsillar abscess?", Laryngoscope, 125(3), pp.537~538 (2015)