A Case of Parotid Gland Epithelial-Myoepithelial Carcinoma With Lung Metastasis: A Review of 26 Cases of Metastatic Epithelial-Myoepithelial Carcinoma
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초록
Epithelial-myoepithelial carcinoma (EMCa) is rare, comprising 1% of all salivary gland tu-mors. Although it is a low-grade cancer, local recurrence occurs in 23%-50% of the cases. Distant metastasis with the rate of 2.6% is rare and there are only 26 cases that have been re-ported to date globally. The lung is the most predominant site of distant metastasis (17 cases),followed by the liver, bones, and the brain. We report here a case of a 68-year-old female diag-nosed with EMCa of the parotid gland, initially managed via parotidectomy and postoperativeradiotherapy. Metastasis in the lung was noted 38 months after radiotherapy, and was treatedwith four cycles of platinum-based chemotherapy. Minor regression of lung nodules was ob-served on computed tomography and was defined as a ‘stable disease.’ Since there is no re-ported case of EMCa with distant metastasis in Korea, we also reviewed 26 cases of metastaticEMCa globally reported.
Abstract
Epithelial-myoepithelial carcinoma (EMCa) is rare, comprising 1% of all salivary gland tu-mors. Although it is a low-grade cancer, local recurrence occurs in 23%-50% of the cases. Distant metastasis with the rate of 2.6% is rare and there are only 26 cases that have been re-ported to date globally. The lung is the most predominant site of distant metastasis (17 cases),followed by the liver, bones, and the brain. We report here a case of a 68-year-old female diag-nosed with EMCa of the parotid gland, initially managed via parotidectomy and postoperativeradiotherapy. Metastasis in the lung was noted 38 months after radiotherapy, and was treatedwith four cycles of platinum-based chemotherapy. Minor regression of lung nodules was ob-served on computed tomography and was defined as a ‘stable disease.’ Since there is no re-ported case of EMCa with distant metastasis in Korea, we also reviewed 26 cases of metastaticEMCa globally reported.
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