항암방사선 치료 후 대세포신경내분비암으로 전환된 상악동 편평세포암 1예
A Case of Maxillary Squamous Cell Carcinoma Transformed to Large Cell Neuroendocrine Carcinoma After Concurrent Chemoradiotherapy
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초록
Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated neuroendocrine car-cinoma that typically arises in the lung. Because of its rarity and poor prognosis, standardizedtreatment has not been established yet. A 53-year-old male was initially diagnosed as a maxil-lary sinus squamous cell carcinoma (SCC) arising from inverted papilloma (clinical stage ofT4bN2bM0, stage IVb), and underwent concurrent chemoradiotherapy. After achieving com-plete remission for 3 years, recurrent tumors were found, of whom the pathologic diagnosisturned out to be LCNEC. He underwent endoscopic transnasal tumor extirpation, followed byadjuvant concurrent chemoradiotherapy. Until postoperative 12 months, he showed no evi-dence of recurrence. To the best of our knowledge, this is the first report of maxillary SCCtransformed to LCNEC after chemoradiotherapy.
Abstract
Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated neuroendocrine car-cinoma that typically arises in the lung. Because of its rarity and poor prognosis, standardizedtreatment has not been established yet. A 53-year-old male was initially diagnosed as a maxil-lary sinus squamous cell carcinoma (SCC) arising from inverted papilloma (clinical stage ofT4bN2bM0, stage IVb), and underwent concurrent chemoradiotherapy. After achieving com-plete remission for 3 years, recurrent tumors were found, of whom the pathologic diagnosisturned out to be LCNEC. He underwent endoscopic transnasal tumor extirpation, followed byadjuvant concurrent chemoradiotherapy. Until postoperative 12 months, he showed no evi-dence of recurrence. To the best of our knowledge, this is the first report of maxillary SCCtransformed to LCNEC after chemoradiotherapy.
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