Effect of Dexamethasone Combination With Gentamicin in Chemical Labyrinthectomy on Hearing Preservation in Patients With Meniere’s Disease
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Chemical labyrinthectomy may be performed in patients with Meniere’s disease who have intractablevertigo that does not respond to drug. By using aminoglycosides, the surgical procedureablates vestibular type 1 hair cells. However, the risk of hearing loss remains a main concernfor clinicians because gentamicin ablates cochlear hair cells as well as vestibular haircells. To deal with the concern for hearing loss, dexamethasone can be combined with gentamicinduring chemical labyrinthectomy. Herein, we show that chemical labyrinthectomy usinggentamicin combined with dexamethasone preserve hearing at high-frequency compared tothe conventional method.
Abstract
Chemical labyrinthectomy may be performed in patients with Meniere’s disease who have intractablevertigo that does not respond to drug. By using aminoglycosides, the surgical procedureablates vestibular type 1 hair cells. However, the risk of hearing loss remains a main concernfor clinicians because gentamicin ablates cochlear hair cells as well as vestibular haircells. To deal with the concern for hearing loss, dexamethasone can be combined with gentamicinduring chemical labyrinthectomy. Herein, we show that chemical labyrinthectomy usinggentamicin combined with dexamethasone preserve hearing at high-frequency compared tothe conventional method.
참고문헌 (12)
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