Age- and Sex-Specific Trends in Oral Cavity Cancer Cancers in a Single Institution From 2000 to 2019 in Korea
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Objectives Head and neck cancer (HNC) represents a significant publichealth challenge worldwide, impacting mortality rates and economic resources. This studyaimed to analyze the age- and sex-specific trends in the prevalence and prognosis of HNCsover two decades. Subjects and Method A retrospective analysis was conducted utilizing data collected dur-ing the period of 2000 to 2019 from the hospital’s Head and Neck Cancer Center. Results We observed that, of the 4167 HNC patients analyzed, the proportion of female withthis cancer has remained unchanged over the past two decades. However, the proportion ofpatients under 40 years of age with oral cavity cancer has significantly increased. We observeda significant improvement in the 3-year overall survival (OS) in HNCs during 2010-2019 c om -pared to 2000-2009. This improvement was particularly pronounced in male, whereas no sig-nificant change was observed in female. Notably, the 3-year OS has significantly improvedover the past decade for advanced-stage (III & IV) patients. Conclusion The incidence of oral cavity cancer has increased among patients under 40years of age over the past two decades. Additionally, the prognosis of oral cavity cancer pa-tients notably improved, particularly in male under 40 years of age.
Abstract
Background and Objectives Head and neck cancer (HNC) represents a significant publichealth challenge worldwide, impacting mortality rates and economic resources. This studyaimed to analyze the age- and sex-specific trends in the prevalence and prognosis of HNCsover two decades. Subjects and Method A retrospective analysis was conducted utilizing data collected dur-ing the period of 2000 to 2019 from the hospital’s Head and Neck Cancer Center. Results We observed that, of the 4167 HNC patients analyzed, the proportion of female withthis cancer has remained unchanged over the past two decades. However, the proportion ofpatients under 40 years of age with oral cavity cancer has significantly increased. We observeda significant improvement in the 3-year overall survival (OS) in HNCs during 2010-2019 c om -pared to 2000-2009. This improvement was particularly pronounced in male, whereas no sig-nificant change was observed in female. Notably, the 3-year OS has significantly improvedover the past decade for advanced-stage (III & IV) patients. Conclusion The incidence of oral cavity cancer has increased among patients under 40years of age over the past two decades. Additionally, the prognosis of oral cavity cancer pa-tients notably improved, particularly in male under 40 years of age.
참고문헌 (25)
- Gormley M, "Reviewing the epidemiology of head and neck cancer: Definitions, trends and risk factors", Br Dent J, 233(9), pp.780~786 (2022)
- Rettig EM, "Epidemiology of head and neck cancer", Surg Oncol Clin N Am, 24(3), pp.379~396 (2015)
- Sung H, "Global cancer statistics 2020 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA Cancer J Clin, 71(3), pp.209~249 (2021)
- Bajpai S, "Tracking changes in age distribution of head and neck cancer in the United States from 1975 to 2016", Clin Otolaryngol, 46(6), pp.1205~1212 (2021)
- Lee SY, "Comparison of oncologic and functional outcomes after transoral robotic lateral oropharyngectomy versus conventional surgery for T1 to T3 tonsillar cancer", Head Neck, 36(8), pp.1138~1145 (2014)
- Cramer JD, "Immunotherapy for head and neck cancer : Recent advances and future directions", Oral Oncol, 99, pp.104460~ (2019)
- Chera BS, "Mature results of a prospective study of deintensified chemoradiotherapy for low-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma", Cancer, 124(11), pp.2347~2354 (2018)
- Malik A, "Trends of oral cancer with regard to age, gender, and subsite over 16 years at a tertiary cancer center in India", Indian J Med Paediatr Oncol, 39(3), pp.297~300 (2018)
- Choi SW, "Trends in the incidence of and survival rates for oral cavity cancer in the Korean population", Oral Dis, 20(8), pp.773~779 (2014)
- Deneuve S, "Diverging incidence trends of oral tongue cancer compared to other head and neck cancers in young adults in France", Int J Cancer, 150(8), pp.1301~1309 (2022)
- Manoharan S, "Ill-fitting dentures and oral cancer : A meta-analysis", Oral Oncol, 50(11), pp.1058~1061 (2014)
- Emfietzoglou R, "Could the endocrine disruptor bisphenol-A be implicated in the pathogenesis of oral and oropharyngeal cancer? Metabolic considerations and future directions", Metabolism, 91, pp.61~69 (2019)
- Hübbers CU, "HPV and cancer of the oral cavity", Virulence, 6(3), pp.244~248 (2015)
- Chung CH, "Epidemiology of oral human papillomavirus infection", Oral Oncol, 50(5), pp.364~369 (2014)
- Hormia M, "Marginal periodontium as a potential reservoir of human papillomavirus in oral mucosa", J Periodontol, 76(3), pp.358~363 (2005)
- Tezal M, "Interaction between chronic inflammation and oral HPV infection in the etiology of head and neck cancers", Int J Otolaryngol, 2012, pp.575242~ (2012)
- Stubenrauch F, "Human papillomavirus life cycle : Active and latent phases", Semin Cancer Biol, 9(6), pp.379~386 (1999)
- von Kroge PR, "The impact of smoking cessation and continuation on recurrence and survival in patients with head and neck cancer : A systematic review of the literature", Oncol Res Treat, 43(10), pp.549~558 (2020)
- Krutz M, "Tobacco cessation after head and neck cancer diagnosis is an independent predictor of treatment response and long-term survival", Oral Oncol, 134, pp.106072~ (2022)
- Chen SW, "Trends in clinical features and survival of oral cavity cancer: Fifty years of experience with 3,362 consecutive cases from a single institution", Cancer Manag Res, 10, pp.4523~4535 (2018)
- Chen Z, "Contrasting male and female trends in tobacco-attributed mortality in China : Evidence from successive nationwide prospective cohort studies", Lancet, 386(10002), pp.1447~1456 (2015)
- Shibata H, "Immunotherapy for head and neck cancer : A paradigm shift from induction chemotherapy to neoadjuvant immunotherapy", Front Oncol, 11, pp.727433~ (2021)
- Budach W, "A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck", BMC Cancer, 6, pp.28~ (2006)
- Pulte D, "Changes in survival in head and neck cancers in the late 20th and early 21st century : A period analysis", Oncologist, 15(9), pp.994~1001 (2010)
- Kim SY, "Are second primary head and neck cancers with previous hematological malignancy more aggressive than de novo head and neck cancers?", Am J Otolaryngol, 44(2), pp.103748~ (2023)