체질량지수와 후두암 발병률의 연관성
Association Between Body Mass Index and the Incidence of Laryngeal Cancer
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초록
Background and Objectives It is unknown whether the presence of low body mass index(BMI) influences the incidence of laryngeal cancer. In a national population-based study, weinvestigated their relationship retrospectively. Subjects and Method Using the data of Korean Health Insurance claims database, we se-lected adults aged 20 years or older who underwent a national health examination from Janu-ary 1, 2007 to December 31, 2008 and were followed up until 2015 for the occurrence of la-ryngeal cancer. The hazard ratio of laryngeal cancer according to BMI and smoking status inthe subjects was analyzed and adjusted for factors such as age, sex, alcohol consumption, andexercise status. Results Finally, a total of 13675470 subjects were included in the study, and we found thatlaryngeal cancer occurred in 3731 of those subjects. The risk of developing laryngeal cancerwas significantly associated with underweight (BMI <18.5 kg/m2) even after adjustment (haz-ard ratio of 1.27; 95% confidence interval of 1.11-1.46). There was also a difference accordingto smoking status. Underweight was not associated with laryngeal cancer in never-smokers,but in ex-smokers and current smokers. Conclusion Being underweight can increase the risk of laryngeal cancer. In particular, thisrisk can increase if you drink and smoke at the same time.
Abstract
Background and Objectives It is unknown whether the presence of low body mass index(BMI) influences the incidence of laryngeal cancer. In a national population-based study, weinvestigated their relationship retrospectively. Subjects and Method Using the data of Korean Health Insurance claims database, we se-lected adults aged 20 years or older who underwent a national health examination from Janu-ary 1, 2007 to December 31, 2008 and were followed up until 2015 for the occurrence of la-ryngeal cancer. The hazard ratio of laryngeal cancer according to BMI and smoking status inthe subjects was analyzed and adjusted for factors such as age, sex, alcohol consumption, andexercise status. Results Finally, a total of 13675470 subjects were included in the study, and we found thatlaryngeal cancer occurred in 3731 of those subjects. The risk of developing laryngeal cancerwas significantly associated with underweight (BMI <18.5 kg/m2) even after adjustment (haz-ard ratio of 1.27; 95% confidence interval of 1.11-1.46). There was also a difference accordingto smoking status. Underweight was not associated with laryngeal cancer in never-smokers,but in ex-smokers and current smokers. Conclusion Being underweight can increase the risk of laryngeal cancer. In particular, thisrisk can increase if you drink and smoke at the same time.
참고문헌 (20)
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