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Study of probiotic and simvastatin additive effect on Helicobacter pylori eradication rate

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Background: Helicobacter pylori infection is a major cause of chronic gastritis, peptic, mucosa associated lymphoid tissueMisdiagnosed as lymphoma and gastric cancer. The eradication rate of H. pylori with standard treatments are decreasing worldwide. The aim of this study was to determine the efficacy of adding simvastatin or probiotic as adjuvant to quadruple therapy on the eradication of H. pylori. Methods: This randomized clinical trial study was conducted on 160 patients with H. pylori. The patients were randomly divided in to 4 groups. The group 1: standard quadruple eradication regimen consisting of two antibiotics (clarithromycin 500 mg and amoxicillin 1 g, all twice per day), a proton pump inhibitor (pantoprazole 40 mg twice daily), Bismuth (120 mg twice daily) with placebo (daily), group 2: standard regimen plus probiotic (daily east 250 mg), group 3: standard regimen supplemented with simvastatin (10 mg daily) and group 4: standard regimen plus simvastatin (20 mg daily) for 14 days was given. The Eradication was determined by stool antigen test at least 1 month after treatment. Results: The risk ratio of eradication of the infection in the simvastatin group 10 mg and simvastatin 20 mg was 0.375 and 0.625 times in compare with the placebo group, indicating a negative effect of simvastatin 10 and 20 mg on the treatment of H. pylori infection, this relationship is not statistically significant (P > 0.05). Conclusion: Due to the high efficacy of simvastatin in H. pylori eradication, further studies are needed to evaluate the use of statins as adjunctive to improve the eradication rate.

Abstract

Background: Helicobacter pylori infection is a major cause of chronic gastritis, peptic, mucosa associated lymphoid tissueMisdiagnosed as lymphoma and gastric cancer. The eradication rate of H. pylori with standard treatments are decreasing worldwide. The aim of this study was to determine the efficacy of adding simvastatin or probiotic as adjuvant to quadruple therapy on the eradication of H. pylori. Methods: This randomized clinical trial study was conducted on 160 patients with H. pylori. The patients were randomly divided in to 4 groups. The group 1: standard quadruple eradication regimen consisting of two antibiotics (clarithromycin 500 mg and amoxicillin 1 g, all twice per day), a proton pump inhibitor (pantoprazole 40 mg twice daily), Bismuth (120 mg twice daily) with placebo (daily), group 2: standard regimen plus probiotic (daily east 250 mg), group 3: standard regimen supplemented with simvastatin (10 mg daily) and group 4: standard regimen plus simvastatin (20 mg daily) for 14 days was given. The Eradication was determined by stool antigen test at least 1 month after treatment. Results: The risk ratio of eradication of the infection in the simvastatin group 10 mg and simvastatin 20 mg was 0.375 and 0.625 times in compare with the placebo group, indicating a negative effect of simvastatin 10 and 20 mg on the treatment of H. pylori infection, this relationship is not statistically significant (P > 0.05). Conclusion: Due to the high efficacy of simvastatin in H. pylori eradication, further studies are needed to evaluate the use of statins as adjunctive to improve the eradication rate.

참고문헌 (37)

  1. Najm WI, "Peptic ulcer disease", Prim Care, 38, pp.383~394 (2011)
  2. Malfertheiner P, "Peptic ulcer disease", Lancet, 374, pp.1449~1461 (2009)
  3. Lau JY, "Systematic review of the epidemiology of complicated peptic ulcer disease : incidence, recurrence, risk factors and mortality", Digestion, 84, pp.102~113 (2011)
  4. Marshall B, "Helicobacter pylori : 20 years on", Clin Med(Lond), 2, pp.147~152 (2002)
  5. Lai CH, "Manipulation of host cholesterol by Helicobacter pylori for their beneficial ecological niche", BioMedicine, 3, pp.27~33 (2013)
  6. Cardenas VM, "Iron deficiency and Helicobacter pylori infection in the United States", Am J Epidemiol, 163, pp.127~134 (2006)
  7. Dholakia KR, "Vitamin B12 deficiency and gastric histopathology in older patients", World J Gastroenterol, 11, pp.7078~7083 (2005)
  8. Fuccio L, "Metaanalysis:can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?", Ann Intern Med, 151, pp.121~128 (2009)
  9. Talley NJ, "Gastric Cancer Consensus conference recommends Helicobacter pylori screening and treatment in asymptomatic persons from high-risk populations to prevent gastric cancer", Am J Gastroenterol, 103, pp.510~514 (2008)
  10. Bourke B, "Canadian Helicobacter Study Group. Canadian Helicobacter Study Group consensus conference:update on the approach to Helicobacter pylori infection in children and adolescents-an evidence-based evaluation", Can J Gastroenterol, 19, pp.399~408 (2005)
  11. Bang CS, "Attempts to enhance the eradication rate of Helicobacter pylori infection", World J Gastroenterol, 20, pp.5252~5262 (2014)
  12. Haider RB, "A randomized-controlled study to compare the efficacy of sequential therapy with standard triple therapy for Helicobacter pylori eradication in an Irish population", Eur J Gastroenterol Hepatol, 27, pp.1265~1269 (2015)
  13. Graham DY, "A report card to grade Helicobacter pylori therapy", Helicobacter, 12, pp.275~278 (2007)
  14. Smith SM, "An update on the treatment of Helicobacter pylori infection", EMJ Gastroenterol, 4, pp.101~107 (2015)
  15. Nseir W, "Randomised clinical trial : simvastatin as adjuvant therapy improves significantly the Helicobacter pylori eradication rate--a placebo-controlled study", Aliment Pharmacol Ther, 36, pp.231~238 (2012)
  16. Bu DX, "Mechanisms for the anti-inflammatory effects of statins", Curr Opin Lipidol, 22, pp.165~170 (2011)
  17. Heeba GH, "Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats : role of nitric oxide and prostaglandins", Eur J Pharmacol, 607, pp.188~193 (2009)
  18. Nseir W, "Long-term statin therapy affects the severity of chronic gastritis", Helicobacter, 15, pp.510~515 (2010)
  19. Onder Bekar, "Kefir Improves the Efficacy and Tolerability of Triple Therapy in Eradicating Helicobacter pylori", Journal of Medicinal Food, 14(4), pp.344~347 (2011), 한국식품영양과학회
  20. Canducci F, "Probiotics and Helicobacter pylori eradication", Dig Liver Dis, 34, pp.S81~S83 (2002)
  21. Kim MN, "The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication", Helicobacter, 13, pp.261~268 (2008)
  22. Cindoruk M, "Efficacy and safety of Saccharomyces boulardii in the 14-day triple anti-Helicobacter pylori therapy : a prospective randomized placebo-controlled double-blind study", Helicobacter, 12, pp.309~316 (2007)
  23. Mahdavi R., "The effect of atorvastatin on the eradication of Helicobacter pylori in patients attending a gastroenterology clinic of Loghman-e-Hakim Hospital", PhD, pp.2014
  24. Thompson PD, "Statin-associated myopathy", JAMA, 289, pp.1681~1690 (2003)
  25. Goldman CG, "Effect of a probiotic food as an adjuvant to triple therapy for eradication of Helicobacter pylori infection in children", Nutrition, 22, pp.984~988 (2006)
  26. Hurduc V, "A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children", Acta Paediatr, 98, pp.127~131 (2009)
  27. Padilla Ruiz M, "Lactobacillus rhamnosus GG supplementation to reduce side-effects of anti-Helicobacter pylori treatment", Rev Gastroenterol Peru, 33, pp.121~130 (2013)[DOI]
  28. Szajewska H, "Randomized, double-blind, placebo-controlled trial : effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children", J pediatr gastroenterol nutr, 48, pp.431~436 (2009)
  29. Yaşar B, "Efficacy of probiotics in Helicobacter pylori eradication therapy", Turk J Gastroenterol, 21, pp.212~217 (2010)
  30. Akcam M, "The effects of probiotics on treatment of Helicobacter pylori eradication in children", Saudi Med J, 36, pp.286~290 (2015)
  31. Saneeyan H, "Effectivness of probiotic on treatment of Helicobacter pylori infection in children", J Isfahan Med Sch, 29, pp.882~889 (2011)
  32. Mirzaee V, "Randomized control trial: comparison of triple therapy plus probiotic yogurt vs. standard triple therapy on Helicobacter pylori eradication", Iran Red Crescent Med J, 14, pp.657~666 (2012)
  33. Du YQ, "Adjuvant probiotics improve the eradication effect of triple therapy for Helicobacter pylori infection", World J Gastroenterol, 18, pp.6302~6307 (2012)
  34. Dinleyici EC, "Saccharomyces boulardii CNCM I-745 in different clinical conditions", Expert Opin Biol Ther, 14, pp.1593~1609 (2014)
  35. Tongtawee T, "Effect of pretreatment with Lactobacillus delbrueckii and Streptococcus thermophillus on tailored triple therapy for Helicobacter pylori eradication : a prospective randomized controlled clinical trial", Asian Pac J Cancer Prev, 16, pp.4885~4890 (2015)
  36. Lü M, "Efficacy of probiotic supplementation therapy for Helicobacter pylori eradication: a meta-analysis of randomized controlled trials", PLoS One, 11, pp.e0163743~ (2016)
  37. Tong JL, "Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy", Aliment Pharmacol Ther, 25, pp.155~168 (2007)

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