Current role of systemic therapy in transarterial chemotherapy-refractory hepatocellular carcinoma patients
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Transarterial chemotherapy (TACE) is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC), defined as large, unresectable, or multinodular HCC in patients with good functional performance. The definition of TACE refractoriness is not well established. Generally, TACE refractoriness is defined as an insufficient response after two or more consecutive TACE. An increase in the number of liver lesions, continuously elevated tumor markers, vascular invasion, and extrahepatic spread also suggest TACE refractoriness. Timely switching to systemic therapy for TACE refractoriness should be considered to improve the outcome. Although data are sparse, the combination of anti-angiogenic and immune checkpoint inhibitor therapies shows promise for TACE-refractory patients. In this article, we review the role of systemic therapy in TACErefractory patients with HCC.
Abstract
Transarterial chemotherapy (TACE) is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC), defined as large, unresectable, or multinodular HCC in patients with good functional performance. The definition of TACE refractoriness is not well established. Generally, TACE refractoriness is defined as an insufficient response after two or more consecutive TACE. An increase in the number of liver lesions, continuously elevated tumor markers, vascular invasion, and extrahepatic spread also suggest TACE refractoriness. Timely switching to systemic therapy for TACE refractoriness should be considered to improve the outcome. Although data are sparse, the combination of anti-angiogenic and immune checkpoint inhibitor therapies shows promise for TACE-refractory patients. In this article, we review the role of systemic therapy in TACErefractory patients with HCC.
참고문헌 (49)
- Vogel A, "Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and followup", Ann Oncol, 29(Suppl 4), pp.iv238~iv255 (2018)
- Chen LT, "Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with intermediate and advanced", relapsed hepatocellular carcinoma:a TOS-ESMO initiative endorsed by CSCO, ISMPO, JSMO, KSMO, MOS and SSO, 2020, pp.31, 334~351
- Kudo M, "A changing paradigm for the treatment of intermediate-stage hepatocellular carcinoma: Asia-Pacific Primary Liver Cancer Expert consensus statements", Liver Cancer, 9, pp.245~260 (2020)
- Golfieri R, "Hepatocellular carcinoma responding to superselective transarterial chemoembolization:an issue of nodule dimension?", J Vasc Interv Radiol, 24, pp.509~517 (2013)
- Peck-Radosavljevic M, "Outcomes of patients (pts) with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE): Global OPTIMIS final analysis", J Clin Oncol, 36(15 Suppl), pp.4018~ (2018)
- Park JW, "Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study", Liver Int, 35, pp.2155~2166 (2015)
- Llovet JM, "Sorafenib in advanced hepatocellular carcinoma", N Engl J Med, 359, pp.378~390 (2008)
- Finn RS, "Atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma", N Engl J Med, 382, pp.1894~1905 (2020)
- Kudo M, "Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma:a randomised phase 3 non-inferiority trial", Lancet, 391, pp.1163~1173 (2018)
- Bruix J, "Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: subanalyses of a phase III trial", J Hepatol, 57, pp.821~829 (2012)
- Yamashita T, "REFLECT-a phase 3 trial comparing efficacy and safety of lenvatinib to sorafenib for the treatment of unresectable hepatocellular carcinoma: an analysis of Japanese subset", J Gastroenterol, 55, pp.113~122 (2020)
- Raoul JL, "How to define transarterial chemoembolization failure or refractoriness: a European perspective", Liver Cancer, 3, pp.119~124 (2014)
- Bruix J, "Clinical decision making and research in hepatocellular carcinoma: pivotal role of imaging techniques", Hepatology, 54, pp.2238~2244 (2011)
- Kudo M, "Management of hepatocellular carcinoma in Japan: consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version", Dig Dis, 29, pp.339~364 (2011)
- Kudo M, "Transarterial chemoembolization failure", refractoriness: JSH-LCSGJ criteria 2014 update, 2014, pp.87(Suppl 1), 22~31
- Cheng AL, "Reevaluating transarterial chemoembolization for the treatment of hepatocellular carcinoma: consensus recommendations and review by an international expert panel", Liver Int, 34, pp.174~183 (2014)
- Surveillance group, "Management consensus guideline for hepatocellular carcinoma: 2016 updated by the Taiwan Liver Cancer Association and the Gastroenterological Society of Taiwan", J Formos Med Assoc, 117, pp.381~403 (2018)
- Jae Seung Lee, "A survey on transarterial chemoembolization refractoriness and a real-world treatment pattern for hepatocellular carcinoma in Korea", Clinical and Molecular Hepatology, 26(1), pp.24~32 (2020), 대한간학회
- Lo CM, "Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma", Hepatology, 35, pp.1164~1171 (2002)
- Llovet JM, "Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival", Hepatology, 37, pp.429~442 (2003)
- Sieghart W, "The ART of decision making: retreatment with transarterial chemoembolization in patients with hepatocellular carcinoma", Hepatology, 57, pp.2261~2273 (2013)
- Hucke F, "The ARTstrategy:sequential assessment of the ART score predicts outcome of patients with hepatocellular carcinoma re-treated with TACE", J Hepatol, 60, pp.118~126 (2014)
- Adhoute X, "Retreatment with TACE: the ABCR SCORE, an aid to the decision-making process", J Hepatol, 62, pp.855~862 (2015)
- Kudo M, "A new treatment option for intermediate-stage hepatocellular carcinoma with high tumor burden: initial lenvatinib therapy with subsequent selective TACE", Liver Cancer, 8, pp.299~311 (2019)
- Jain RK, "Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy", Science, 307, pp.58~62 (2005)
- Kano MR, "Comparison of the effects of the kinase inhibitors imatinib, sorafenib, and transforming growth factor-beta receptor inhibitor on extravasation of nanoparticles from neovasculature", Cancer Sci, 100, pp.173~180 (2009)
- Carmeliet P, "Angiogenesis in cancer and other diseases", Nature, 407, pp.249~257 (2000)
- Tohyama O, "Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models", J Thyroid Res, 2014, pp.638747~ (2014)
- Arizumi T, "Validation of the criteria of transcatheter arterial chemoembolization failure or refractoriness in patients with advanced hepatocellular carcinoma proposed by the LCSGJ", Oncology, 87(Suppl 1), pp.32~36 (2014)
- Lencioni R, "Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC:the SPACE trial", J Hepatol, 64, pp.1090~1098 (2016)
- Meyer T, "Sorafenib in combination with transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma (TACE 2): a randomised placebo-controlled, double-blind, phase 3 trial", Lancet Gastroenterol Hepatol, 2, pp.565~575 (2017)
- Kudo M, "Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma:TACTICS trial", Gut, 69, pp.1492~1501 (2020)
- Matsui J, "Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factorreceptor (VEGF-R) 2 and VEGF-R3 kinase", Clin Cancer Res, 14, pp.5459~5465 (2008)
- Matsui J, "E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition", Int J Cancer, 122, pp.664~671 (2008)
- Yamada K, "Phase I dose-escalation study and biomarker analysis of E7080 in patients with advanced solid tumors", Clin Cancer Res, 17, pp.2528~2537 (2011)
- Boss DS, "A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours", Br J Cancer, 106, pp.1598~1604 (2012)
- Kudo M, "Extremely high objective response rate of lenvatinib: its clinical relevance and changing the treatment paradigm in hepatocellular carcinoma", Liver Cancer, 7, pp.215~224 (2018)
- Kudo M, "Lenvatinib as an initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteria and child-pugh a liver function: a proof-of-concept study", Cancers (Basel), 11, pp.1084~ (2019)
- Kawamura Y, "Pretreatment heterogeneous enhancement pattern of hepatocellular carcinoma may be a useful new predictor of early response to lenvatinib and overall prognosis", Liver Cancer, 9, pp.275~292 (2020)
- Kawamura Y, "18F-fluorodeoxyglucose uptake in hepatocellular carcinoma as a useful predictor of an extremely rapid response to lenvatinib", Liver Cancer, 9, pp.84~92 (2020)
- Ding X, "Transarterial chemoembolization plus lenvatinib versus transarterial chemoembolization plus sorafenib as firstline treatment for hepatocellular carcinoma with portal vein tumor thrombus: a prospective randomized study", Cancer, 127, pp.3782~3793 (2021)
- Kudo M, "Brivanib as adjuvant therapy to transarterial chemoembolization in patients with hepatocellular carcinoma:a randomized phase III trial", Hepatology, 60, pp.1697~1707 (2014)
- Kudo M, "Orantinib versus placebo combined with transcatheter arterial chemoembolisation in patients with unresectable hepatocellular carcinoma (ORIENTAL): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study", Lancet Gastroenterol Hepatol, 3, pp.37~46 (2018)
- Yau T, "CheckMate 459:a randomized, multi-center phase III study of nivolumab (NIVO) vs sorafenib (SOR)as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma (aHCC)", Annal Oncol, 30, pp.v874~v875 (2019)
- Finn RS, "Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial", J Clin Oncol, 38, pp.193~202 (2020)
- Duffy AG, "Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma", J Hepatol, 66, pp.545~551 (2017)
- Chang Y, "Recent updates of transarterial chemoembolilzation in hepatocellular carcinoma", Int J Mol Sci, 21, pp.8165~ (2020)
- Cheng AL, "IMbrave150: efficacy and safety results from a ph III study evaluating atezolizumab (atezo) + bevacizumab (bev) vs sorafenib (Sor) as first treatment (tx) for patients (pts) with unresectable hepatocellular carcinoma (HCC)", Annal Oncol, 30, pp.ix186~ix187 (2019)
- Kudo M, "A new era of systemic therapy for intermediate and advanced stage hepatocellular carcinoma", Hepatobiliary Surg Nutr, 9, pp.530~533 (2020)
