본문 바로가기
KERD
논문KCI 등재

Bleeding complication after endoscopic submucosal dissection of gastric neoplasm

Ji Yong Ahn
소화기인터벤션의학회 (The Society of Gastrointestinal Intervention)|2019.07|International Journal of Gastrointestinal Intervention|제8권 제3호|pp. 123-126|DOI 10.18528/ijgii190006

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

NeoplasmHemorrhageStomachEndoscopic resection

초록

Endoscopic submucosal dissection (ESD) is recognized as an effective treatment for superficial gastric neoplasm without metastasis because results of ESD show the high en bloc resection rate and low local recurrence rate. Recently, the indications for ESD have been broadened in the field of therapeutic endoscopy with regard to its safety and efficacy. However, complications can be happened after procedure and post-ESD bleeding is one of the major adverse events which may lead to serious clinical situation of patient. The mechanism of post-ESD ulcer which is made by iatrogenic procedure is different from peptic ulcer which is created under low pH, therefore, the risk factors and treatment methods of post-ESD bleeding is somewhat different from peptic ulcer bleeding. With these reasons, endoscopist should know about the definitions and influencing factors of post-ESD bleeding before and after procedure, and should manage using proper hemostatic methods when post-ESD bleeding is happened. In this review, I try to overview about the post-ESD bleeding and to know the methods of treatment and prevention of bleeding.

Abstract

Endoscopic submucosal dissection (ESD) is recognized as an effective treatment for superficial gastric neoplasm without metastasis because results of ESD show the high en bloc resection rate and low local recurrence rate. Recently, the indications for ESD have been broadened in the field of therapeutic endoscopy with regard to its safety and efficacy. However, complications can be happened after procedure and post-ESD bleeding is one of the major adverse events which may lead to serious clinical situation of patient. The mechanism of post-ESD ulcer which is made by iatrogenic procedure is different from peptic ulcer which is created under low pH, therefore, the risk factors and treatment methods of post-ESD bleeding is somewhat different from peptic ulcer bleeding. With these reasons, endoscopist should know about the definitions and influencing factors of post-ESD bleeding before and after procedure, and should manage using proper hemostatic methods when post-ESD bleeding is happened. In this review, I try to overview about the post-ESD bleeding and to know the methods of treatment and prevention of bleeding.

참고문헌 (47)

  1. Rembacken BJ, "Endoscopic mucosal resection", Endoscopy, 33, pp.709~718 (2001)
  2. Soetikno R, "Endoscopic mucosal resection for early cancers of the upper gastrointestinal tract", J Clin Oncol, 23, pp.4490~4498 (2005)
  3. Ahn JY, "Endoscopic and oncologic outcomes after endoscopic resection for early gastric cancer: 1370 cases of absolute and extended indications", Gastrointest Endosc, 74, pp.485~493 (2011)
  4. Takeuchi Y, "Endoscopic submucosal dissection with insulated-tip knife for large mucosal early gastric cancer : a feasibility study(with videos)", Gastrointest Endosc, 66, pp.186~193 (2007)
  5. Choi KS, "EMR versus gastrectomy for intramucosal gastric cancer: comparison of long-term outcomes", Gastrointest Endosc, 73, pp.942~948 (2011)
  6. Takizawa K, "Routine coagulation of visible vessels may prevent delayed bleeding after endoscopic submucosal dissection--an analysis of risk factors", Endoscopy, 40, pp.179~183 (2008)
  7. Park YM, "The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis", Surg Endosc, 25, pp.2666~2677 (2011)
  8. Lian J, "A meta-analysis of endoscopic submucosal dissection and EMR for early gastric cancer", Gastrointest Endosc, 76, pp.763~770 (2012)
  9. Na S, "Delayed bleeding rate according to the forrest classification in second-look endoscopy after endoscopic submucosal dissection", Dig Dis Sci, 60, pp.3108~3117 (2015)
  10. Miyahara K, "Perforation and postoperative bleeding of endoscopic submucosal dissection in gastric tumors: analysis of 1190 lesions in low- and high-volume centers in Saga, Japan", Digestion, 86, pp.273~280 (2012)
  11. Mannen K, "Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions", J Gastroenterol, 45, pp.30~36 (2010)
  12. Park SE, "Risk factors and correlations of immediate, early delayed, and late delayed bleeding associated with endoscopic resection for gastric neoplasms", Surg Endosc, 30, pp.625~632 (2016)
  13. Jeon SW, "Predictors of immediate bleeding during endoscopic submucosal dissection in gastric lesions.", Surg Endosc, 23, pp.1974~1979 (2009)
  14. Sato C, "Postoperative bleeding in patients on antithrombotic therapy after gastric endoscopic submucosal dissection", World J Gastroenterol, 23, pp.5557~5566 (2017)
  15. Matsumura T, "Risk factors for early and delayed post-operative bleeding after endoscopic submucosal dissection of gastric neoplasms, including patients with continued use of antithrombotic agents", BMC Gastroenterol, 14, pp.172~ (2014)
  16. Kono Y, "Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy", J Gastroenterol Hepatol, 33, pp.453~460 (2018)
  17. Tsuji Y, "Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions", World J Gastroenterol, 16, pp.2913~2917 (2010)
  18. Numata N, "Clinical outcomes of endoscopic submucosal dissection for early gastric cancer in patients with chronic kidney disease", J Gastroenterol Hepatol, 28, pp.1632~1637 (2013)
  19. Choi YK, "Outcomes of endoscopic submucosal dissection for gastric epithelial neoplasm in chronic kidney disease patients : propensity score-matched case-control analysis", Gastric Cancer, 22, pp.164~171 (2019)
  20. Kato M, "Outcomes of ESD for patients with early gastric cancer and comorbid liver cirrhosis : a propensity score analysis", Surg Endosc, 29, pp.1560~1566 (2015)
  21. Choi YK, "Efficacy and safety of endoscopic submucosal dissection for gastric neoplasms in patients with compensated liver cirrhosis: a propensity score-matched case-control study", Gastrointest Endosc, 87, pp.1423~1431 (2018)
  22. Cho SJ, "Aspirin use and bleeding risk after endoscopic submucosal dissection in patients with gastric neoplasms", Endoscopy, 44, pp.114~121 (2012)
  23. Dong J, "Effects of antithrombotic therapy on bleeding after endoscopic submucosal dissection", Gastrointest Endosc, 86, pp.807~816 (2017)
  24. So S, "Comparison of the effects of antithrombotic therapy on delayed bleeding after gastric endoscopic resection: a propensity score-matched case-control study", Gastrointest Endosc, 89, pp.277~285 (2019)
  25. Chung IK, "Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms:Korean ESD Study Group multicenter study", Gastrointest Endosc, 69, pp.1228~1235 (2009)
  26. Koh R, "Antithrombotic drugs are risk factors for delayed postoperative bleeding after endoscopic submucosal dissection for gastric neoplasms", Gastrointest Endosc, 78, pp.476~483 (2013)
  27. Yano T, "Different clinical characteristics associated with acute bleeding and delayed bleeding after endoscopic submucosal dissection in patients with early gastric cancer", Surg Endosc, 31, pp.4542~4550 (2017)
  28. Yoshioka T, "Renal dysfunction is an independent risk factor for bleeding after gastric ESD", Endosc Int Open, 3, pp.E39~E45 (2015)
  29. Kearon C, "Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)", Chest, 133(6 Suppl), pp.454S~545S (2008)
  30. Antithrombotic Trialists’ Collaboration, "Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients", BMJ, 324, pp.71~86 (2002)
  31. Lim JH, "Do antiplatelets increase the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms?", Gastrointest Endosc, 75, pp.719~727 (2012)
  32. Furuhata T, "Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy", Gastric Cancer, 20, pp.207~214 (2017)
  33. Uedo N, "Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial", Am J Gastroenterol, 102, pp.1610~1616 (2007)
  34. Tomita T, "Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection", J Gastroenterol Hepatol, 27, pp.1441~1446 (2012)
  35. Imaeda H, "Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia", J Gastroenterol, 46, pp.1267~1272 (2011)
  36. Mukai S, "Postprocedural combined treatment using the coagulation plus artery-selective clipping(2C)method for the prevention of delayed bleeding after ESD", Surg Endosc, 27, pp.1292~1301 (2013)
  37. Onoda Y, "Effects of 12-sulfodehydroabietic acid monosodium salt(TA-2711), a new anti-ulcer agent, on gastric mucosal lesions induced by necrotizing agents and gastric mucosal defensive factors in rats", Jpn J Pharmacol, 52, pp.631~638 (1990)
  38. Ye BD, "Omeprazole may be superior to famotidine in the management of iatrogenic ulcer after endoscopic mucosal resection: a prospective randomized controlled trial", Aliment Pharmacol Ther, 24, pp.837~843 (2006)
  39. Yamaguchi Y, "A prospective randomized trial of either famotidine or omeprazole for the prevention of bleeding after endoscopic mucosal resection and the healing of endoscopic mucosal resection-induced ulceration", Aliment Pharmacol Ther, 21(Suppl 2), pp.111~115 (2005)
  40. Ahn JY, "The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: a randomized prospective study", J Dig Dis, 16, pp.75~82 (2015)
  41. Uedo N, "Endoscopic Doppler US for the prevention of ulcer bleeding after endoscopic submucosal dissection for early gastric cancer: a preliminary study (with video)", Gastrointest Endosc, 72, pp.444~448 (2010)
  42. Hirasawa K, "Coagulation syndrome: delayed perforation after colorectal endoscopic treatments", World J Gastrointest Endosc, 7, pp.1055~1061 (2015)
  43. 이보인, "Routine Mucosal Closure with a Detachable Snare and Clips after Endoscopic Submucosal Dissection for Gastric Epithelial Neoplasms: A Randomized Controlled Trial", Gut and Liver, 5(4), pp.454~459 (2011), 거트앤리버 소화기연관학회협의회
  44. Kantsevoy SV, "Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos)", Gastrointest Endosc, 79, pp.503~507 (2014)
  45. Nomura T, "Thread-assisted mucosal defect closure using the locking-clip technique after gastric endoscopic submucosal dissection", Endoscopy, 50, pp.E342~E343 (2018)
  46. Tsuji Y, "Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video)", Gastrointest Endosc, 81, pp.906~912 (2015)
  47. Kawata N, "Efficacy of polyglycolic acid sheets and fibrin glue for prevention of bleeding after gastric endoscopic submucosal dissection in patients under continued antithrombotic agents", Gastric Cancer, 21, pp.696~702 (2018)

관련 논문AI추천

Preventing and Controlling Bleeding in Gastric Endoscopic Submucosal Dissection박찬혁, 이상길대한소화기내시경학회 · Clinical Endoscopy2013 · 제46권 제5호Clinical Impact of Second-Look Endoscopy after Endoscopic Submucosal Dissection of Gastric Neoplasms문원, 김형훈, 박무인, 박선자거트앤리버 소화기연관학회협의회 · Gut and Liver2012 · 제6권 제3호Is a Second-Look Endoscopy Necessary after Endoscopic Submucosal Dissection for Gastric Neoplasm?강기주, 김은란, 김재준, 김정하, 민병훈, 이종철, 이준행, 이풍렬거트앤리버 소화기연관학회협의회 · Gut and Liver2015 · 제9권 제1호Management of Complications of Colorectal Submucosal Dissection김은란, Dong Kyung Chang대한소화기내시경학회 · Clinical Endoscopy2019 · 제52권 제2호Short-Term Healing Process of Artificial Ulcers after Gastric Endoscopic Submucosal DissectionChihiro Minatsuki, Kazuhiko Koike, Keiko Niimi, Mitsuhiro Fujishiro, Nobutake Yamamichi, Osamu Goto, Satoshi Ono, Shinya Kodashima거트앤리버 소화기연관학회협의회 · Gut and Liver2011 · 제5권 제3호Second-Look Endoscopy after Gastric Endoscopic Submucosal Dissection for Reducing Delayed Postoperative Bleeding이혁, 박준철, 박찬혁, 신성관, 이상길, 이용찬거트앤리버 소화기연관학회협의회 · Gut and Liver2015 · 제9권 제1호

이 간행물의 다른 논문 (8건)

Endoscopic submucosal dissection in the WestAlexander Podboy, Shai Friedlandpp. 106-109Endoscopic management of ampullary neoplasmSunguk Jangpp. 110-115Management of antithrombotic agents and current issues in patients undergoing endoscopic submucosal dissectionChan Hyuk Parkpp. 116-122Endoscopic closure devices: A review of technique and application for hemostasisRaymond Kim, Jennifer Wellington, Andrew Canakispp. 127-133Endovascular hemostasis for endoscopic procedure-related gastrointestinal bleedingJi Hoon Shin, Jong Woo Kim, Minho Parkpp. 134-139
원문 보기