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On the genotype frequencies and generating function for frequencies in a dyploid model

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For a locus with two alleles ($I^A$ and $I^B$), the frequencies of the alleles are represented by $$ p=f(I^A)= \frac {2N_{AA} +N_{AB}} {2N} , \ q=f(I^B)= \frac {2N_{BB} +N_{AB}}{2N}$$ where $N_{AA},~N_{AB}$ and $N_{BB}$ are the numbers of $I^A I^A ,~I^A I^B$ and $I^B I^B$ respectively and $N$ is the total number of populations. The frequencies of the genotypes expected are calculated by using $p^2 ,~2pq$ and $q^2$. So in this paper, we consider the method of whether some genotypes is in Hardy-Weinburg equilibrium. Also we calculate the probability generating function for the offspring number of genotype produced by a mating of the $i$th male and $j$th female under a diploid model of $N$ population with $N_1$ males and $N_2$ females. Finally, we have conditional joint probability generating function of genotype frequencies.

Abstract

For a locus with two alleles ($I^A$ and $I^B$), the frequencies of the alleles are represented by $$ p=f(I^A)= \frac {2N_{AA} +N_{AB}} {2N} , \ q=f(I^B)= \frac {2N_{BB} +N_{AB}}{2N}$$ where $N_{AA},~N_{AB}$ and $N_{BB}$ are the numbers of $I^A I^A ,~I^A I^B$ and $I^B I^B$ respectively and $N$ is the total number of populations. The frequencies of the genotypes expected are calculated by using $p^2 ,~2pq$ and $q^2$. So in this paper, we consider the method of whether some genotypes is in Hardy-Weinburg equilibrium. Also we calculate the probability generating function for the offspring number of genotype produced by a mating of the $i$th male and $j$th female under a diploid model of $N$ population with $N_1$ males and $N_2$ females. Finally, we have conditional joint probability generating function of genotype frequencies.

참고문헌 (3)

  1. 최원, "On the probability of genotypes in population genetics", 한국수학논문집, 28(1), pp.1~7 (2020), 강원경기수학회
  2. R. Lewis, "Human Genetics : Concepts and Applications" (2016), McGraw-Hill Education
  3. B.A. Pierce, "Genetics Essentials : Concepts and Connections", pp.216~240 (2014), W. H. Freeman and Company

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