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Antifungal Susceptibility to Amphotericin B, Fluconazole, Voriconazole, and Flucytosine in Candida Bloodstream Isolates from 15 Tertiary Hospitals in Korea

최현정|김수현|이경원|박연준|신종희|이위교|주민영|정숙인
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2012.11|Annals of Laboratory Medicine|제32권 제6호|pp. 426-428

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키워드

CandidaFluconazoleAmphotericin BVoriconazoleFlucytosine
주제분류병리학

초록

The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMérieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea.

Abstract

The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMérieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea.

참고문헌 (6)

  1. Pfaller MA, "Multicenter comparison of the VITEK 2 antifungal susceptibility test with the CLSI broth microdilution reference method for testing amphotericin B, flucytosine, and voriconazole against Candida spp", J Clin Microbiol, 45, pp.3522~3528 (2007)
  2. Pfaller MA, "Multicenter comparison of the VITEK 2 yeast susceptibility test with the CLSI broth microdilution reference method for testing fluconazole against Candida spp", J Clin Microbiol, 45, pp.796~802 (2007)
  3. Bourgeois N, "Antifungal susceptibility of 205 Candida spp. isolated primarily during invasive candidiasis and comparison of the Vitek 2 system with the CLSI broth microdilution and Etest methods", J Clin Microbiol, 48, pp.154~161 (2010)
  4. 장숙진, "Detection of Amphotericin B Resistance in Candida haemulonii and Closely Related Species by Use of the Etest, Vitek-2 Yeast Susceptibility System, and CLSI and EUCAST Broth Microdilution Methods", JOURNAL OF CLINICAL MICROBIOLOGY, 50(6), pp.1852~1855, AMER SOC MICROBIOLOGY
  5. Jung SI, "Multicenter surveillance of species distribution and antifungal susceptibilities of Candida bloodstream isolates in South Korea", Med Mycol, 48, pp.669~674 (2010)
  6. Messer SA, "Potency of anidulafungin compared to nine other antifungal agents tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: results from the global SENTRY Antimicrobial Surveillance Program", J Clin Microbiol, 48, pp.2984~2987 (2010)

관련 논문AI추천

In Vitro Fluconazole and Voriconazole Susceptibilities of Candida Bloodstream Isolates in Korea: Use of the CLSI and EUCAST Epidemiological Cutoff Values김미나, 김수현, 서순팔, 송은송, 신명근, 신종희, 양동욱, 이경원, 이미경, 이위교, 이혜수, 장민중, 장철훈, 장희창대한진단검사의학회 · Annals of Laboratory Medicine2013 · 제33권 제3호A Multicenter Study of Antifungal Use and Species Distribution and Antifungal Susceptibilities of Candida Isolates in South Korea김수현, 김영아, 신경섭, 신정환, 신종희, 신주현, 원은정, 이다인, 이동현, 이종윤, 정석훈대한의진균학회 · 대한의진균학회지2020 · 제25권 제1호Species Distribution and Antifungal Susceptibilities of Yeast Clinical Isolates from Three Hospitals in Korea, 2001 to 2007김명숙, 김미나, 용동은, 이경원, 이미경대한진단검사의학회 · Annals of Laboratory Medicine2010 · 제30권 제4호CLSI 액체배지 미량희석법, Etest 및 Minimum Fungicidal Concentration 검사에 의한 국내 혈액에서 분리된 효모균의 시험관 내 Amphotericin B 내성 성적어영, 기승정, 김수현, 김의종, 박지영, 서순팔, 신명근, 신종희, 양동욱대한진단검사의학회 · Annals of Laboratory Medicine2008 · 제28권 제5호Species Distribution and Susceptibility to Azole Antifungals of Candida Bloodstream Isolates from Eight University Hospitals in Korea어영, 김미나, 김수현, 서순팔, 신명근, 신보문, 신종희, 양동욱, 이경원, 이위교, 이진솔, 이혜수, 장철훈연세대학교의과대학 · Yonsei Medical Journal2007 · 제48권 제5호국내 분리 칸디다균주에 대한 VITEK-2 항진균제 감수성 검사(AST-YS01)의 평가기승정, 김다운, 김수현, 서순팔, 신명근, 신종희, 양동욱대한임상미생물학회 · Annals of Clinical Microbiology2009 · 제12권 제3호

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