Necrotizing Pneumonia and Empyema in an Immunocompetent Patient Caused by Nocardia cyriacigeorgica and Identified by 16S rRNA and secA1 Sequencing
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Nocardiosis is a rare and potentially life-threatening infection. Nocardia species are a group of aerobic actinomycetes, which are filamentous, branching, gram-positive, and acid-fast bacilli [1]. Worldwide, respiratory and disseminated infections are most often due to N. asteroids complex, which is increasingly recog- nized as an opportunistic infection in immunocompromised hosts with underlying HIV infection, neoplastic disease, or long- term high-dose corticosteroid therapy [2]. Recently, infection of N. cyriacigeorgica was reported in an immunocompromised pa- tient in Korea, which was identified by 16S rRNA sequencing analysis and additional biochemical tests combined to draw a conclusion [3]. Here, we describe a case of necrotizing pneu- monia and empyema caused by N. cyriacigeorgica in a 77-yr- old Korean male patient who was immunocompetent. This case was diagnosed by DNA amplification and sequence analyses of the 16S rRNA and secA1 genes.
Abstract
Nocardiosis is a rare and potentially life-threatening infection. Nocardia species are a group of aerobic actinomycetes, which are filamentous, branching, gram-positive, and acid-fast bacilli [1]. Worldwide, respiratory and disseminated infections are most often due to N. asteroids complex, which is increasingly recog- nized as an opportunistic infection in immunocompromised hosts with underlying HIV infection, neoplastic disease, or long- term high-dose corticosteroid therapy [2]. Recently, infection of N. cyriacigeorgica was reported in an immunocompromised pa- tient in Korea, which was identified by 16S rRNA sequencing analysis and additional biochemical tests combined to draw a conclusion [3]. Here, we describe a case of necrotizing pneu- monia and empyema caused by N. cyriacigeorgica in a 77-yr- old Korean male patient who was immunocompetent. This case was diagnosed by DNA amplification and sequence analyses of the 16S rRNA and secA1 genes.
참고문헌 (17)
- Conville PS, "Manual of clinical microbiology. 10th ed", pp.443~471 (2011), American Society for Microbiology
- Uttamchandani RB, "Nocardiosis in 30 patients with advanced human immunodeficiency virus infection: clinical features and outcome", Clin Infect Dis, 18, pp.348~353 (1994)
- 오혜룡, "A Strain of Nocardia cyriacigeorgica Isolated from a Patient with Pulmonary Infection", Annals of Clinical Microbiology, 11(2), pp.136~140 (2008), 대한임상미생물학회
- Clinical and Laboratory Standards Institute, "Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; approved guideline. Document MM18-A", Clinical and Laboratory Standards Institute, ~ (2008)
- Economou A, "SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion", Cell, 78, pp.835~843 (1994)
- Conville PS, "Analysis of secA1 gene sequences for identification of Nocardia species", J Clin Microbiol, 44, pp.2760~2766 (2006)
- Aiyar RS, "Identification of mitochondrial disease genes through integrative analysis of multiple datasets", Methods, 46, pp.248~255 (2008)
- Tamura K, "MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods", Mol Biol Evol, 28, pp.2731~2739 (2011)
- Matulionyte R, "Secular trends of nocardia infection over 15 yr in a tertiary care hospital", J Clin Pathol, 57, pp.807~812 (2004)
- Wallace RJ Jr, "New Nocardia taxon among isolates of Nocardia brasiliensis associated with invasive disease", J Clin Microbiol, 33, pp.1528~1533 (1995)
- Conville PS, "Identification of nocardia species by restriction endonuclease analysis of an amplified portion of the 16S rRNA gene", J Clin Microbiol, 38, pp.158~164 (2000)
- Yassin AF, "Nocardia cyriacigeorgici sp. nov", Int J Syst Evol Microbiol, 51, pp.1419~1423 (2001)
- Georghiou PR, "Infection with Nocardia species in Queensland. A review of 102 clinical isolates", Med J Aust, 156, pp.156~692 (1992)
- Schlaberg R, "Nocardia cyriacigeorgica, an emerging pathogen in the United States", J Clin Microbiol, 46, pp.265~273 (2008)
- Clinical and Laboratory Standards Institute, "Susceptibility testing of Mycobacteria, Nocardiae, and other actinomycetes; approved Standard-Second edition, Document M24-A2", Clinical and Laboratory Standards Institute, ~ (2011)
- Roth A, "Phylogeny of the genus Nocardia based on reassessed 16S rRNA gene sequences reveals underspeciation and division of strains classified as Nocardia asteroides into three established species and two unnamed taxons", J Clin Microbiol, 41, pp.851~856 (2003)
- Kong F, "secA1 gene sequence polymorphisms for species identification of Nocardia species and recognition of intraspecies genetic diversity", J Clin Microbiol, 48, pp.3928~3934 (2010)