Evaluation of the Optimal Neutrophil Gelatinase- Associated Lipocalin Value as a Screening Biomarker for Urinary Tract Infections in Children
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Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker in the detection of kidney injury. Early diagnosis of urinary tract infection (UTI), one of the most common infections in children, is important in order to avert long-term conse- quences. We assessed whether serum NGAL (sNGAL) or urine NGAL (uNGAL) would be reliable markers of UTI and evaluated the appropriate diagnostic cutoff value for the screening of UTI in children. Methods: A total of 812 urine specimens and 323 serum samples, collected from pediat- ric patients, were analyzed. UTI was diagnosed on the basis of culture results and symp- toms reported by the patients. NGAL values were measured by using ELISA. Results: NGAL values were more elevated in the UTI cases than in the non-UTI cases, but the difference between the values were not statistically significant ( P =0.190 for sN- GAL and P =0.064 for uNGAL). The optimal diagnostic cutoff values of sNGAL and uN- GAL for UTI screening were 65.25 ng/mL and 5.75 ng/mL, respectively. Conclusions: We suggest that it is not appropriate to use NGAL as a marker for early diag- nosis of UTI in children.
Abstract
Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a promising biomarker in the detection of kidney injury. Early diagnosis of urinary tract infection (UTI), one of the most common infections in children, is important in order to avert long-term conse- quences. We assessed whether serum NGAL (sNGAL) or urine NGAL (uNGAL) would be reliable markers of UTI and evaluated the appropriate diagnostic cutoff value for the screening of UTI in children. Methods: A total of 812 urine specimens and 323 serum samples, collected from pediat- ric patients, were analyzed. UTI was diagnosed on the basis of culture results and symp- toms reported by the patients. NGAL values were measured by using ELISA. Results: NGAL values were more elevated in the UTI cases than in the non-UTI cases, but the difference between the values were not statistically significant ( P =0.190 for sN- GAL and P =0.064 for uNGAL). The optimal diagnostic cutoff values of sNGAL and uN- GAL for UTI screening were 65.25 ng/mL and 5.75 ng/mL, respectively. Conclusions: We suggest that it is not appropriate to use NGAL as a marker for early diag- nosis of UTI in children.
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