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Discovery of a Fluoroquinolone-Resistant Serratia marcescens Clinical Isolate without Quinolone Resistance-Determining Region Mutations

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초록

Sir, Serratia marcescens , once considered to be an innocuous and non-pathogenic organism, is now an important cause of hospital- acquired infections. This organism is associated with respiratory tract infections, urinary tract infections, septicemia, meningitis, and wound infections [1, 2]. S. marcescens infections are difficult to treat because of high resistance to a wide variety of antibiotics, including cephalosporins, fluoroquinolones, and aztreonam [2].

Abstract

Sir, Serratia marcescens , once considered to be an innocuous and non-pathogenic organism, is now an important cause of hospital- acquired infections. This organism is associated with respiratory tract infections, urinary tract infections, septicemia, meningitis, and wound infections [1, 2]. S. marcescens infections are difficult to treat because of high resistance to a wide variety of antibiotics, including cephalosporins, fluoroquinolones, and aztreonam [2].

참고문헌 (8)

  1. Mahlen SD, "Serratia infections: from military experiments to current practice", Clin Microbiol Rev, 24, pp.755~791 (2011)
  2. Yang HF, "Plasmid-mediated quinolone resistance in extended-spectrum-β-lactamase- and AmpC β-lactamaseproducing Serratia marcescens in China", Antimicrob Agents Chemother, 56, pp.4529~4531 (2012)
  3. Ruiz J, "Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection", J Antimicrob Chemother, 51, pp.1109~1117 (2003)
  4. Strahilevitz J, "Plasmid-mediated quinolone resistance: a multifaceted threat", Clin Microbiol Rev, 22, pp.664~689 (2009)
  5. Clinical and Laboratory Standards Institute, "Performance standards for antimicrobial susceptibility testing, Twenty-Second Informational supplement, M100-S22" (2012), CLSI
  6. Ruiz J, "Transferable mechanisms of quinolone resistance", Int J Antimicrob Agents, 40, pp.196~203 (2012)
  7. Sato T, "A fluoroquinolone-resistant Escherichia coli clinical isolate without quinolone resistance-determining region mutations found in Japan", Antimicrob Agents Chemother, 55, pp.3964~3965 (2011)
  8. Chopra S, "A fluoroquinolone-resistant Acinetobacter baumannii without the quinolone resistance-determining region mutations", J Antimicrob Chemother, 66, pp.2668~2670 (2011)

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