Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways

키워드

참고문헌 (100)

1. Nilson I, "Exon", intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias, 1996, pp.93, 966~972
2. Ziemin-van der Poel S, "Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias", Proc Natl Acad Sci USA, 88, pp.10735~10739 (1991)
3. Corral J, "An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes", Cell, 85, pp.853~861 (1996)
4. Lavau C, "Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL", EMBO J, 16, pp.4226~4237 (1997)
5. DiMartino JF, "A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL", Blood, 96, pp.3887~3893 (2000)
6. DiMartino JF, "The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10", Blood, 99, pp.3780~3785 (2002)
7. So CW, "Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9", Blood, 103, pp.3192~3199 (2004)
8. Krivtsov AV, "H3K79 methylation profiles define murine and human MLL-AF4 leukemias", Cancer Cell, 14, pp.355~368 (2008)
9. Bursen A, "The AF4-MLL fusion protein is capable of inducing ALL in mice without requirement of MLL-AF4", Blood, 115, pp.3570~3579 (2010)
10. Greaves M, "When one mutation is all it takes", Cancer Cell, 27, pp.433~434 (2015)
11. Jude CD, "Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors", Cell Stem Cell, 1, pp.324~337 (2007)
12. Arai S, "Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells", Blood, 117, pp.6304~6314 (2011)
13. Huang X, "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells", Leukemia, 28, pp.1081~1091 (2014)
14. Zhou J, "PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS", HOX pathway, 2014, pp.28, 1436~1448
15. Park SM, "Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program", J Clin Invest, 125, pp.1286~1298 (2015)
16. Meyer C, "The MLL recombinome of acute leukemias in 2013", Leukemia, 27, pp.2165~2176 (2013)
17. Balgobind BV, "Novel prognostic subgroups in childhood 11q23", MLL-rearranged acute myeloid leukemia: results of an international retrospective study, 2009, pp.114, 2489~2496
18. Ayton PM, "Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9", Genes Dev, 17, pp.2298~2307 (2003)
19. Ernst P, "An Mll-dependent Hox program drives hematopoietic progenitor expansion", Curr Biol, 14, pp.2063~2069 (2004)
20. Abecasis GR, "A map of human genome variation from population-scale sequencing", Nature, 467, pp.1061~1073 (2010)
21. Reichel M, "Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation", Oncogene, 17, pp.3035~3044 (1998)
22. Gillert E, "A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells", Oncogene, 18, pp.4663~4671 (1999)
23. Stephens PJ, "Massive genomic rearrangement acquired in a single catastrophic event during cancer development", Cell, 144, pp.27~40 (2011)
24. Djabali M, "A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias", Nat Genet, 2, pp.113~118 (1992)
25. Tkachuk DC, "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias", Cell, 71, pp.691~700 (1992)
26. Gu Y, "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene", Cell, 71, pp.701~708 (1992)
27. Rasio D, "Complete exon structure of the ALL1 gene", Cancer Res, 56, pp.1766~1769 (1996)
28. Meyer C, "Genomic DNA of leukemic patients: target for clinical diagnosis of MLL rearrangements", Biotechnol J, 1, pp.656~663 (2006)
29. Rössler T, "An alternative splice process renders the MLL protein either into a transcriptional activator or repressor", Pharmazie, 68, pp.601~607 (2013)
30. Zeisig DT, "The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin", Oncogene, 24, pp.5525~5532 (2005)
31. Bitoun E, "The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling", Hum Mol Genet, 16, pp.92~106 (2007)
32. Mueller D, "Misguided transcriptional elongation causes mixed lineage leukemia", PLoS Biol, 7, pp.e1000249~ (2009)
33. Benedikt A, "The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures", Leukemia, 25, pp.135~144 (2011)
34. Hsieh JJ, "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression", Cell, 115, pp.293~303 (2003)
35. Adler HT, "HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A", J Biol Chem, 272, pp.28407~28414 (1997)
36. Adler HT, "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5", INI1 proteins, 1999, pp.19, 7050~7060
37. Nakamura T, "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation", Mol Cell, 10, pp.1119~1128 (2002)
38. Yokoyama A, "Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties", Blood, 100, pp.3710~3718 (2002)
39. Xia ZB, "MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein", Proc Natl Acad Sci USA, 100, pp.8342~8347 (2003)
40. Yokoyama A, "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression", Mol Cell Biol, 24, pp.5639~5649 (2004)
41. Wysocka J, "WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development", Cell, 121, pp.859~872 (2005)
42. Dou Y, "Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF", Cell, 121, pp.873~885 (2005)
43. Dou Y, "Regulation of MLL1 H3K4 methyltransferase activity by its core components", Nat Struct Mol Biol, 13, pp.713~719 (2006)
44. Milne TA, "Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis", Mol Cell, 38, pp.853~863 (2010)
45. Muntean AG, "The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis", Cancer Cell, 17, pp.609~621 (2010)
46. Chang PY, "Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription", J Mol Biol, 400, pp.137~144 (2010)
47. Hom RA, "Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain", J Mol Biol, 400, pp.145~154 (2010)
48. Wang Z, "Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression", Cell, 141, pp.1183~1194 (2010)
49. Schraets D, "MLL-mediated transcriptional gene regulation investigated by gene expression profiling", Oncogene, 22, pp.3655~3668 (2003)
50. Chen J, "Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization", Cancer Res, 68, pp.6199~6207 (2008)
51. Muntean AG, "The PHD fingers of MLL block MLL fusion protein-mediated transformation", Blood, 112, pp.4690~4693 (2008)
52. Hayette S, "Recurrent involvement of the MLL gene in adult T-lineage acute lymphoblastic leukemia", Blood, 99, pp.4647~4649 (2002)
53. Quigley DI, "Pediatric T-cell acute lymphoblastic leukemia with aberrations of both MLL loci", Cancer Genet Cytogenet, 168, pp.77~79 (2006)
54. Türkmen S, "Involvement of the MLL gene in adult T-lymphoblastic leukemia", Genes Chromosomes Cancer, 51, pp.1114~1124 (2012)
55. Broeker PL, "Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites", Blood, 87, pp.1912~1922 (1996)
56. Cimino G, "Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias", Cancer Res, 57, pp.2879~2883 (1997)
57. Felix CA, "MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children", J Pediatr Hematol Oncol, 20, pp.299~308 (1998)
58. Reichel M, "Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL", Oncogene, 20, pp.2900~2907 (2001)
59. Wang J, "ECSASB2 mediates MLL degradation during hematopoietic differentiation", Blood, 119, pp.1151~1161 (2012)
60. Marschalek R, "It takes two-to-leukemia: about addictions and requirements", Leuk Res, 35, pp.424~425 (2011)
61. Emerenciano M, "The distribution of MLL breakpoints correlates with outcome in infant acute leukaemia", Br J Haematol, 161, pp.224~236 (2013)
62. Scholz B, "AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions", Am J Blood Res, 5, pp.10~24 (2015)
63. Gaussmann A, "Combined effects of the two reciprocal t(4;11) fusion proteins MLL-AF4 and AF4-MLL confer resistance to apoptosis, cell cycling capacity and growth transformation", Oncogene, 26, pp.3352~3363 (2007)
64. Eberle I, "Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells", Nucleic Acids Res, 38, pp.5384~5395 (2010)
65. Takahashi K, "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors", Cell, 126, pp.663~676 (2006)
66. Smith E, "The super elongation complex (SEC) and MLL in development and disease", Genes Dev, 25, pp.661~672 (2011)
67. Luo Z, "The super elongation complex (SEC) family in transcriptional control", Nat Rev Mol Cell Biol, 13, pp.543~547 (2012)
68. Zheng X, "BCR and its mutants, the reciprocal t(9;22)-associated ABL", BCR fusion proteins, differentially regulate the cytoskeleton and cell motility, 2006, pp.6, 262~
69. Zheng X, "Reciprocal t(9;22) ABL", BCR fusion proteins: leukemogenic potential and effects on B cell commitment, 2009, pp.4, e7661~
70. Rafiei A, "The functional interplay between the t(9;22)-associated fusion proteins BCR", ABL and ABL, PLoS Genet, pp.2015, 11[DOI]
71. Essers MA, "Targeting leukemic stem cells by breaking their dormancy", Mol Oncol, 4, pp.443~450 (2010)
72. Walf-Vorderwülbecke V, "Frat2 mediates the oncogenic activation of Rac by MLL fusions", Blood, 120, pp.4819~4828 (2012)
73. Wang Z, "Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy", Nature, 455, pp.1205~1209 (2008)
74. Maucuer A, "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains", Proc Natl Acad Sci USA, 92, pp.3100~3104 (1995)
75. Jackson BC, "An ELMO2-RhoG-ILK network modulates microtubule dynamics", Mol Biol Cell, 26, pp.2712~2725 (2015)
76. Cassimeris L, "The oncoprotein 18", stathmin family of microtubule destabilizers, 2002, pp.14, 18~24
77. Holmfeldt P, "Upregulated Op18", stathmin activity causes chromosomal instability through a mechanism that evades the spindle assembly checkpoint, 2010, pp.316, 2017~2026
78. João Agostinho Machado-Neto, "Stathmin 1 in normal and malignant hematopoiesis", BMB Reports, 47(12), pp.660~665 (2014), 생화학분자생물학회
79. Slagsvold T, "Endosomal and non-endosomal functions of ESCRT proteins", Trends Cell Biol, 16, pp.317~326 (2006)
80. Webber J, "Extracellular vesicles as modulators of the cancer microenvironment", Semin Cell Dev Biol, 40, pp.27~34 (2015)
81. Boyiadzis M, "Information transfer by exosomes: a new frontier in hematologic malignancies", Blood Rev, 29, pp.281~290 (2015)
82. Mathivanan S, "Exosomes: extracellular organelles important in intercellular communication", J Proteomics, 73, pp.1907~1920 (2010)
83. Prokopi M, "The secret role of microRNAs in cancer stem cell development and potential therapy: a Notch-pathway approach", Front Oncol, 4, pp.389~ (2015)
84. Shilatifard A, "Identification and purification of the Holo-ELL complex. Evidence for the presence of ELL-associated proteins that suppress the transcriptional inhibitory activity of ELL", J Biol Chem, 273, pp.11212~11217 (1998)
85. Kamura T, "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose", J Biol Chem, 276, pp.16528~16533 (2001)
86. Kushwah R, "Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human", EMBO Rep, 15, pp.1128~1138 (2014)
87. Gao X, "Ribosomal protein s3: a multifunctional target of attaching", effacing bacterial pathogens, 2011, pp.2, 137~
88. Daigle SR, "Potent inhibition of DOT1L as treatment of MLL-fusion leukemia", Blood, 122, pp.1017~1025 (2013)
89. Borkin D, "Pharmacologic iInhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo", Cancer Cell, 27, pp.589~602 (2015)
90. Jones WD, "De novo mutations in MLL cause Wiedemann-Steiner syndrome", Am J Hum Genet, 91, pp.358~364 (2012)
91. Ahmad K, "Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL", Oncogenesis, 3, pp.e127~ (2014)
92. Bursen A, "Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?", Oncogene, 23, pp.6237~6249 (2004)
93. Kumar AR, "t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL", Leuk Res, 35, pp.305~309 (2011)
94. Sanders DS, "Significance of AF4-MLL reciprocal fusion in t(4;11) leukemias?", Leuk Res, 35, pp.299~300 (2011)
95. Emerenciano M, "Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential", Cancer Lett, 332, pp.30~34 (2013)
96. Wilkinson AC, "RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction", Cell Rep, 3, pp.116~127 (2013)
97. Wächter K, "Functional characterisation of different MLL fusion proteins by using inducible Sleeping Beauty vectors", Cancer Lett, 352, pp.196~202 (2014)
98. Breese EH, "Use of genome engineering to create patient specific MLL translocations in primary human hematopoietic stem and progenitor cells", PLoS ONE, 10, pp.e0136644~ (2015)
99. Sabiani S, "Unraveling the activation mechanism of Taspase1 which controls the oncogenic AF4-MLL fusion protein", EBioMedicine, 2, pp.386~395 (2015)
100. Cao F, "Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia", Mol Cell, 53, pp.247~261 (2014)

관련 논문AI추천