본문 바로가기
KERD
논문KCI 등재

Prevalence and Clinical Impact of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolated From Hospitalized Patients

1

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류병리학

초록

Background: We estimated the prevalence and clinical impact of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA). The concordance between macromethod and glycopeptide resistance detection (GRD) E tests was determined. In addition, predictors of clinical outcomes in hospitalized patients with S. aureus bacteremia (SAB) or pneumonia (SAP) were evaluated. Methods: We obtained 229 consecutive S. aureus isolates from all hospitalized patients at two university hospitals located in Busan and Yangsan, Korea. Standard, macromethod, and GRD E tests were performed. Additionally, we reviewed the medical records of all patients. Among the 229 patients, predictors of clinical outcomes were analyzed for 107 patients with SAB and 39 with SAP. Results: Among the 229 isolates, 34.5% of S. aureus isolates and 50.7% of methicillin-resistant S. aureus isolates exhibited the hVISA phenotype based on the macromethod E test. hVISA was nearly associated with treatment failure in patients with SAB (P=0.054) and was significantly associated with treatment failure in patients with SAP (P=0.014). However, hVISA was not associated with 30-day mortality in patients with SAB or SAP. The concordance between the macromethod and GRD E tests was 84.2%. Conclusions: hVISA is quite common in the southeastern part of Korea. hVISA is associated with treatment failure in patients with SAP.

Abstract

Background: We estimated the prevalence and clinical impact of heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA). The concordance between macromethod and glycopeptide resistance detection (GRD) E tests was determined. In addition, predictors of clinical outcomes in hospitalized patients with S. aureus bacteremia (SAB) or pneumonia (SAP) were evaluated. Methods: We obtained 229 consecutive S. aureus isolates from all hospitalized patients at two university hospitals located in Busan and Yangsan, Korea. Standard, macromethod, and GRD E tests were performed. Additionally, we reviewed the medical records of all patients. Among the 229 patients, predictors of clinical outcomes were analyzed for 107 patients with SAB and 39 with SAP. Results: Among the 229 isolates, 34.5% of S. aureus isolates and 50.7% of methicillin-resistant S. aureus isolates exhibited the hVISA phenotype based on the macromethod E test. hVISA was nearly associated with treatment failure in patients with SAB (P=0.054) and was significantly associated with treatment failure in patients with SAP (P=0.014). However, hVISA was not associated with 30-day mortality in patients with SAB or SAP. The concordance between the macromethod and GRD E tests was 84.2%. Conclusions: hVISA is quite common in the southeastern part of Korea. hVISA is associated with treatment failure in patients with SAP.

참고문헌 (40)

  1. Klevens RM, "Invasive methicillin-resistant Staphylococcus aureus infections in the United States", JAMA, 298, pp.1763~1771 (2007)
  2. Appelbaum PC, "The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus", Clin Microbiol Infect, 12(S1), pp.S16~S23 (2006)
  3. Cui L, "Cell wall thickening is a common feature of vancomycin resistance in Staphylococcus aureus", J Clin Microbiol, 41, pp.5~14 (2003)
  4. Hiramatsu K, "Vancomycin-resistant Staphylococcus aureus: a new model of antibiotic resistance", Lancet Infect Dis, 1, pp.147~155 (2001)
  5. Hiramatsu K, "Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility", J Antimicrob Chemother, 40, pp.135~136 (1997)
  6. Hiramatsu K, "Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin", Lancet, 350, pp.1670~1673 (1997)
  7. Sieradzki K, "The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection", N Engl J Med, 340, pp.517~523 (1999)
  8. Smith TL, "Emergence of vancomycin resistance in Staphylococcus aureus", N Engl J Med, 340, pp.493~501 (1999)
  9. Kim MN, "Vancomycin-intermediate Staphylococcus aureus in Korea", J Clin Microbiol, 38, pp.3879~3881 (2000)
  10. Kim MN, "Clonal spread of Staphylococcus aureus heterogeneously resistant to vancomycin in a university hospital in Korea", J Clin Microbiol, 40, pp.1376~1380 (2002)
  11. Song JH, "Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin", Antimicrob Agents Chemother, 48, pp.4926~4928 (2004)
  12. Park KH, "Comparison of the clinical features, bacterial genotypes and outcomes of patients with bacteremia due to heteroresistant vancomycin-intermediate Staphylococcus aureus and vancomycin-susceptible S. aurues", J Antimicrob Chemother, 67, pp.1843~1849 (2012)
  13. Wootton M, "A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital", J Antimicrob Chemother, 47, pp.399~403 (2001)
  14. Howden BP, "Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection, and clinical implications", Clin Microbiol Rev, 23, pp.99~139 (2010)
  15. Yusof A, "Evaluation of a new E test vancomycin-teicoplanin strip for detection of glycopeptide-intermediate Staphylococcus aureus (GISA), in particular, heterogeneous GISA", J Clin Microbiol, 46, pp.3042~3047 (2008)
  16. Leonard SN, "Evaluation of the E test GRD for the detection of Staphylococcus aureus with reduced susceptibility to glycopeptides", J Antimicrob Chemother, 63, pp.489~492 (2009)
  17. Satola SW, "Comparison of detection methods for heteroresistant vancomycin-intermediate Staphylococcus aureus, with the population analysis profile method as the reference method", J Clin Microbiol, 49, pp.177~183 (2011)
  18. Charles PG, "Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus", Clin Infect Dis, 38, pp.448~451 (2004)
  19. Musta AC, "Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteremia: trends over 11 years", J Clin Microbiol, 47, pp.1640~1644 (2009)
  20. Horne KC, "Prospective comparison of the clinical impacts of heterogeneous vancomycin-intermediate methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-susceptible MRSA", Antimicrob Agents Chemother, 53, pp.3447~3452 (2009)
  21. Maor Y, "Prevalence and characteristics of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteremia in a tertiary care center", J Clin Microbiol, 45, pp.1511~1514 (2007)
  22. Fong RK, "Clinical features and treatment outcomes of vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) in a tertiary care institution in Singapore", Eur J Clin Microbiol Infect Dis, 28, pp.983~987 (2009)
  23. Bae IG, "Heterogeneous vancomycin-intermediate susceptibility phenotype in bloodstream methicillin-resistant Staphylococcus aureus isolates from an international cohort of patients with infective endocarditis: prevalence, genotype, and clinical significance", J Infect Dis, 200, pp.1355~1366 (2009)
  24. Neoh HM, "Impact of reduced vancomycin susceptibility on the therapeutic outcome of MRSA bloodstream infections", Ann Clin Microbiol Antimicrob, 6, pp.13~ (2007)
  25. CLSI, "Performance standards for antimicrobial susceptibility testing. Twenty-fifth Informational supplement", Clinical and Laboratory Standards Institute, ~ (2015)
  26. Levy MM, "2001 SCCM", ESICM, ATS, pp.SIS International Sepsis Definitions Conference, Crit Care Med[DOI]
  27. Guilarde AO, "Staphylococcus aureus bacteraemia: incidence, risk factors and predictors for death in a Brazilian teaching hospital", J Hosp Infect, 63, pp.330~336 (2006)
  28. Durack DT, "New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service", Am J Med, 96, pp.200~209 (1994)
  29. Harbarth S, "Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus", Arch Intern Med, 158, pp.182~189 (1998)
  30. Lew DP, "Osteomyelitis", Lancet, 364, pp.369~379 (2004)
  31. Mylotte JM, "Staphylococcus aureus bacteremia: predictors of 30-day mortality in a large cohort", Clin Infect Dis, 31, pp.1170~1174 (2000)
  32. Horan TC, "CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections", Infect Control Hosp Epidemiol, 13, pp.606~608 (1992)
  33. González C, "Bacteremic pneumonia due to Staphylococcus aureus: A comparison of disease caused by methicillin-resistant and methicillin-susceptible organisms", Clin Infect Dis, 29, pp.1171~1177 (1999)
  34. Kumar M, "Persistent pneumonia: Underlying cause and outcome", Indian J Pediatr, 76, pp.1223~1226 (2009)
  35. Rybak MJ, "Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007)", J Clin Microbiol, 46, pp.2950~2954 (2008)
  36. van Hal SJ, "Systemic review and meta-analysis of the significance of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates", Antimicrob Agents Chemother, 55, pp.405~410 (2011)
  37. Liu C, "Staphylococcus aureus with heterogeneous resistance to vancomycin: epidemiology, clinical significance, and critical assessment of diagnostic methods", Antimicrob Agents Chemother, 47, pp.3040~3045 (2003)
  38. Sieradzki K, "Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus", J Bacteriol, 185, pp.7103~7110 (2003)
  39. Kullar R, "Impact of vancomycin exposure on outcomes in patients with methicillin-resistant Staphylococcus aureus bacteremia: support for consensus guidelines suggested targets", Clin Infect Dis, 52, pp.975~981 (2011)
  40. Howden BP, "Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility", Clin Infect Dis, 38, pp.521~528 (2004)

관련 논문AI추천

Molecular Typing and Resistance Profiles of Vancomycin-Intermediate Staphylococcus aureus in Korea: Results from a National Surveillance Study, 2007-2013박찬, 강기수, 김일환, 김정욱, 김화수, 유재연, 유재일, 이광준, 이영선대한임상미생물학회 · Annals of Clinical Microbiology2016 · 제19권 제4호Clinical and microbiological factors associated with early patient mortality from methicillinresistant Staphylococcus aureus bacteremia김탁, 김성한, 김양수, 박기호, 박수진, 방경미, 우준희, 이상오, 정용필, 정진용, 최상호대한내과학회 · The Korean Journal of Internal Medicine2019 · 제34권 제1호Impact of Community-Onset Methicillin-Resistant Staphylococcus aureus on Staphylococcus aureus Bacteremia in a Central Korea Veterans Health Service Hospital김미나, 김춘관, 배은신, 성흥섭, 장정현, 최윤미대한진단검사의학회 · Annals of Laboratory Medicine2019 · 제39권 제2호Accessory Gene Regulator Polymorphism and Vancomycin Minimum Inhibitory Concentration in Methicillin-Resistant Staphylococcus aureus강희정, 김미영, 김재석, 김한성, 김현수, 박민정, 송원근, 이영경대한진단검사의학회 · Annals of Laboratory Medicine2015 · 제35권 제4호Development of a Single-nucleotide Polymorphism Genotyping Assay for the Rapid Detection of Vancomycin-intermediate Resistance in Staphylococcus aureus Epidemic Lineage ST5이광준, Kim Jung Wook대한진단검사의학회 · Annals of Laboratory Medicine2023 · 제43권 제4호The Prevalence, Genotype and Antimicrobial Susceptibility of High- and Low-Level Mupirocin Resistant Methicillin-Resistant Staphylococcus aureus김신무, 박석돈, 박세영대한피부과학회 · Annals of Dermatology2012 · 제24권 제1호

이 간행물의 다른 논문 (18건)